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Hypertension, Vol 24, 793-801, Copyright © 1994 by American Heart Association
P Verdecchia, C Porcellati, G Schillaci, C Borgioni, A Ciucci, M Battistelli, M Guerrieri, C Gatteschi, I Zampi, A Santucci and G Reboldi
To determine the prognostic significance of ambulatory blood pressure, we
prospectively followed for up to 7.5 years (mean, 3.2) 1187 subjects with
essential hypertension and 205 healthy normotensive control subjects who
had baseline off-therapy 24-hour noninvasive ambulatory blood pressure
monitoring. Prevalence of white coat hypertension, defined by an average
daytime ambulatory blood pressure lower than 131/86 mm Hg in women and
136/87 mm Hg in men in clinically hypertensive subjects, was 19.2%.
Cardiovascular morbidity, expressed as the number of combined fatal and
nonfatal cardiovascular events per 100 patient-years, was 0.47 in the
normotensive group, 0.49 in the white coat hypertension group, 1.79 in
dippers with ambulatory hypertension, and 4.99 in nondippers with
ambulatory hypertension. After adjustment for traditional risk markers for
cardiovascular disease, morbidity did not differ between the normotensive
and white coat hypertension groups (P = .83). Compared with the white coat
hypertension group, cardiovascular morbidity increased in ambulatory
hypertension in dippers (relative risk, 3.70; 95% confidence interval, 1.13
to 12.5), with a further increase of morbidity in nondippers (relative
risk, 6.26; 95% confidence interval, 1.92 to 20.32). After adjustment for
age, sex, diabetes, and echocardiographic left ventricular hypertrophy
(relative risk versus subjects with normal left ventricular mass, 1.82; 95%
confidence interval, 1.02 to 3.22), cardiovascular morbidity in ambulatory
hypertension was higher (P = .0002) in nondippers than in dippers in women
(relative risk, 6.79; 95% confidence interval, 2.45 to 18.82) but not in
men (P = .91). Our findings suggest that ambulatory blood pressures
stratifies cardiovascular risk in essential hypertension independent of
clinic blood pressure and other traditional risk markers including
echocardiographic left ventricular hypertrophy.(ABSTRACT TRUNCATED AT 250
WORDS)
ARTICLES
Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension [published erratum appears in Hypertension 1995 Mar;25(3):462]
Ospedale Generale Regionale R. Silvestrini, Unita Organica di Malattie Cardiovascolari e Medicina Interna, Perugia PG, Italy.
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F. Garcia-Rio, J. M. Pino, A. Alonso, M. A. Arias, I. Martinez, D. Alvaro, and J. Villamor White Coat Hypertension in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome Chest, March 1, 2004; 125(3): 817 - 822. [Abstract] [Full Text] [PDF]
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 H. Negishi, J.-W. Xu, K. Ikeda, M. Njelekela, Y. Nara, and Y. Yamori Black and Green Tea Polyphenols Attenuate Blood Pressure Increases in Stroke-Prone Spontaneously Hypertensive Rats J. Nutr., January 1, 2004; 134(1): 38 - 42. [Abstract] [Full Text] [PDF]
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P. Verdecchia, F. Angeli, and R. Gattobigio Clinical Usefulness of Ambulatory Blood Pressure Monitoring J. Am. Soc. Nephrol., January 1, 2004; 15(90010): S30 - 33. [Abstract] [Full Text]
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R. C. Hermida and D. E. Ayala Sampling Requirements for Ambulatory Blood Pressure Monitoring in the Diagnosis of Hypertension in Pregnancy Hypertension, October 1, 2003; 42(4): 619 - 624. [Abstract] [Full Text] [PDF]
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R. C. Hermida, C. Calvo, D. E. Ayala, J. E. Lopez, J. R. Fernandez, A. Mojon, M. J. Dominguez, and M. Covelo Seasonal Variation of Fibrinogen in Dipper and Nondipper Hypertensive Patients Circulation, September 2, 2003; 108(9): 1101 - 1106. [Abstract] [Full Text] [PDF]
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R. C. Hermida, C. Calvo, D. E. Ayala, M. J. Dominguez, M. Covelo, J. R. Fernandez, A. Mojon, and J. E. Lopez Administration Time-Dependent Effects of Valsartan on Ambulatory Blood Pressure in Hypertensive Subjects Hypertension, September 1, 2003; 42(3): 283 - 290. [Abstract] [Full Text] [PDF]
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G. Mancia, G. Parati, P. Castiglioni, R. Tordi, E. Tortorici, F. Glavina, and M. Di Rienzo Daily Life Blood Pressure Changes Are Steeper in Hypertensive Than in Normotensive Subjects Hypertension, September 1, 2003; 42(3): 277 - 282. [Abstract] [Full Text] [PDF]
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S. C. Textor, S. J. Taler, T. S. Larson, M. Prieto, M. Griffin, J. Gloor, S. Nyberg, J. Velosa, T. Schwab, and M. Stegall Blood Pressure Evaluation among Older Living Kidney Donors J. Am. Soc. Nephrol., August 1, 2003; 14(8): 2159 - 2167. [Abstract] [Full Text] [PDF]
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 J. A. Miller, J. R. Curtis, and E. B. Sochett Relationship Between Diurnal Blood Pressure, Renal Hemodynamic Function, and the Renin-Angiotensin System in Type 1 Diabetes Diabetes, July 1, 2003; 52(7): 1806 - 1811. [Abstract] [Full Text] [PDF]
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D. L. Clement, M. L. De Buyzere, D. A. De Bacquer, P. W. de Leeuw, D. A. Duprez, R. H. Fagard, P. J. Gheeraert, L. H. Missault, J. J. Braun, R. O. Six, et al. Prognostic Value of Ambulatory Blood-Pressure Recordings in Patients with Treated Hypertension N. Engl. J. Med., June 12, 2003; 348(24): 2407 - 2415. [Abstract] [Full Text] [PDF]
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 C. Morisco, J. Sadoshima, B. Trimarco, R. Arora, D. E. Vatner, and S. F. Vatner Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus Am J Physiol Heart Circ Physiol, April 1, 2003; 284 (4): H1043 - H1047. [Full Text] [PDF]
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K. Bjorklund, L. Lind, B. Zethelius, B. Andren, and H. Lithell Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men Circulation, March 11, 2003; 107(9): 1297 - 1302. [Abstract] [Full Text] [PDF]
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 M. Liu, H. Takahashi, Y. Morita, S. Maruyama, M. Mizuno, Y. Yuzawa, M. Watanabe, T. Toriyama, H. Kawahara, and S. Matsuo Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients Nephrol. Dial. Transplant., March 1, 2003; 18(3): 563 - 569. [Abstract] [Full Text] [PDF]
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P. Verdecchia, G. Reboldi, R. Gattobigio, M. Bentivoglio, C. Borgioni, F. Angeli, E. Carluccio, M. G. Sardone, and C. Porcellati Atrial Fibrillation in Hypertension: Predictors and Outcome Hypertension, February 1, 2003; 41(2): 218 - 223. [Abstract] [Full Text] [PDF]
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A. R. Schwartz, W. Gerin, K. W. Davidson, T. G. Pickering, J. F. Brosschot, J. F. Thayer, N. Christenfeld, and W. Linden Toward a Causal Model of Cardiovascular Responses to Stress and the Development of Cardiovascular Disease Psychosom Med, January 1, 2003; 65(1): 22 - 35. [Abstract] [Full Text] [PDF]
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F. H. Messerli, W. B. White, and J. A. Staessen If only cardiologists did properly measure blood pressure: Blood pressure recordings in daily practice and clinical trials J. Am. Coll. Cardiol., December 18, 2002; 40(12): 2201 - 2203. [Abstract] [Full Text] [PDF]
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Y. Higashi, K. Nakagawa, M. Kimura, K. Noma, K. Hara, S. Sasaki, C. Goto, T. Oshima, K. Chayama, and M. Yoshizumi Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers J. Am. Coll. Cardiol., December 4, 2002; 40(11): 2039 - 2043. [Abstract] [Full Text] [PDF]
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 L. Poulsen Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 222 - 242. [Abstract] [PDF]
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A. Covic and D. Goldsmith Ambulatory blood pressure monitoring: an essential tool for blood pressure assessment in uraemic patients Nephrol. Dial. Transplant., October 1, 2002; 17(10): 1737 - 1741. [Full Text] [PDF]
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M. Koc, A. Toprak, H. Tezcan, A. Bihorac, E. Akoglu, and I. C. Ozener Uncontrolled hypertension due to volume overload contributes to higher left ventricular mass index in CAPD patients Nephrol. Dial. Transplant., September 1, 2002; 17(9): 1661 - 1666. [Abstract] [Full Text] [PDF]
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R. C. Hermida, C. Calvo, D. E. Ayala, J. R. Fernandez, L. M. Ruilope, and J. E. Lopez Evaluation of the extent and duration of the "ABPM effect" in hypertensive patients J. Am. Coll. Cardiol., August 21, 2002; 40(4): 710 - 717. [Abstract] [Full Text] [PDF]
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K. L. Gupta Isolated Office Hypertension: Ambulatory BP Monitoring Is the Only Answer Arch Intern Med, July 8, 2002; 162(13): 1526 - 1526. [Full Text] [PDF]
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G. Schillaci, L. Pasqualini, P. Verdecchia, G. Vaudo, S. Marchesi, C. Porcellati, G. de Simone, and E. Mannarino Prognostic significance of left ventricular diastolic dysfunction in essential hypertension J. Am. Coll. Cardiol., June 19, 2002; 39(12): 2005 - 2011. [Abstract] [Full Text] [PDF]
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 J. A. S. Barreto-Filho, M. R. S. Alcantara, R. Salvatori, M. A. Barreto, A. C. S. Sousa, V. Bastos, A. H. Souza, R. M. C. Pereira, P. E. Clayton, M. S. Gill, et al. Familial Isolated Growth Hormone Deficiency Is Associated with Increased Systolic Blood Pressure, Central Obesity, and Dyslipidemia J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2018 - 2023. [Abstract] [Full Text] [PDF]
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P. Verdecchia, G. Schillaci, C. Borgioni, R. Gattobigio, G. Ambrosio, and C. Porcellati Prevalent influence of systolic over pulse pressure on left ventricular mass in essential hypertension Eur. Heart J., April 2, 2002; 23(8): 658 - 665. [Abstract] [Full Text] [PDF]
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W. B. White, J. Kent, A. Taylor, K. M. Verburg, J. B. Lefkowith, and A. Whelton Effects of Celecoxib on Ambulatory Blood Pressure in Hypertensive Patients on ACE Inhibitors Hypertension, April 1, 2002; 39(4): 929 - 934. [Abstract] [Full Text] [PDF]
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P. Verdecchia, G. Reboldi, C. Porcellati, G. Schillaci, S. Pede, M. Bentivoglio, F. Angeli, S. Norgiolini, and G. Ambrosio Risk of cardiovascular disease in relation to achieved office and ambulatory blood pressure control in treated hypertensive subjects J. Am. Coll. Cardiol., March 6, 2002; 39(5): 878 - 885. [Abstract] [Full Text] [PDF]
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