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(Hypertension. 1995;25:88-91.)
© 1995 American Heart Association, Inc.

Articles

Racial Differences in Epinephrine and ß₂-Adrenergic Receptors

Paul J. Mills; Joel E. Dimsdale; Michael G. Ziegler; Richard A. Nelesen

From the University of California at San Diego Medical Center, San Diego.

Abstract This study examined the effects of ethnicity and hypertension on ß₂-adrenergic receptors and on plasma catecholamines in a group of 77 unmedicated mildly hypertensive and normotensive men. Black hypertensive subjects had the most sensitive and white hypertensive subjects the least sensitive ß-receptors (as assessed by isoproterenol-stimulated cyclic AMP in lymphocytes [P=.02]). In contrast, postreceptor adenylate cyclase activation (as assessed by forskolin stimulation) was similar among groups. As with ß-receptor sensitivity, black hypertensive subjects had the highest ß-receptor density and white hypertensive subjects the lowest (P=.03). Blacks demonstrated lower plasma epinephrine values compared with whites (P=.03). Across all subjects, plasma epinephrine was negatively correlated with ß-receptor density (r=-.26, P<.05) and sensitivity (r=-.25, P<.05). There were no group differences in binding affinity to the ß-antagonist iodopindolol. The findings support the notion of increased ß-adrenergic receptors in hypertension in blacks.

Key Words: catecholamines • receptors, adrenergic, beta • race • hypertension, essential • lymphocytes

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