This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Benetos, A. Articles by Safar, M. E. Search for Related Content PubMed PubMed Citation Articles by Benetos, A. Articles by Safar, M. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB POTASSIUM CYANIDE SODIUM CHLORIDE

(Hypertension. 1995;25:272-277.)
© 1995 American Heart Association, Inc.

Articles

Carotid Artery Mechanical Properties of Dahl Salt-Sensitive Rats

Athanase Benetos; Hervé Bouaziz; Pierre Albaladejo; David Guez; Michel E. Safar

From the Department of Internal Medicine and INSERM (U337), Broussais Hospital, Paris, France.

Abstract We evaluated the mechanical properties of the carotid artery in anesthetized Dahl rats with or without long-term treatment with the diuretic compound indapamide. The mechanical properties of the carotid artery were evaluated by establishing pressure-volume curves in situ in vivo before and after total relaxation of arterial smooth muscle by potassium cyanide. Dahl salt-sensitive and salt-resistant rats were fed either a low (0.4%) or high (7%) NaCl diet for 5 weeks. In each group, half the rats received for the same period of time oral treatment with indapamide (3 mg/kg per day). Blood pressure, heart rate, and pressure-volume curves were studied at the end of the 5-week period. In untreated Dahl salt-sensitive rats, the pressure-volume curve of the carotid artery was shifted to the right compared with that in untreated Dahl salt-resistant rats. The finding was observed even after potassium cyanide and regardless of the NaCl diet (P<.01 between Dahl salt-sensitive and -resistant rats). Indapamide was able to prevent the development of hypertension in Dahl salt-sensitive rats receiving a high NaCl diet (185±7 versus 146±8 mm Hg in untreated and treated Dahl salt-sensitive rats with a high NaCl diet, P<.0005). In the other groups, indapamide had no effect on blood pressure. Indapamide treatment increased carotid arterial static compliance in Dahl salt-sensitive rats with a high or low NaCl diet and to a lesser extent in Dahl salt-resistant rats. The increase was observed even after total relaxation of carotid arterial smooth muscle by potassium cyanide. These results suggest that (1) the mechanical properties of the carotid arteries were altered in Dahl salt-sensitive rats independently of NaCl diet and transmural pressure changes, and (2) the diuretic compound indapamide prevented the disturbed mechanical properties of the carotid artery in Dahl salt-sensitive rats with a high or low NaCl diet, acting on both arterial structure and function. Sodium sensitivity (and not sodium intake) influences the changes in the carotid artery mechanical properties of Dahl rats.

Key Words: compliance • sodium • indapamide • hypertension, sodium-dependent • carotid artery

This article has been cited by other articles:

				J. Seidlerova, J. A. Staessen, M. Maillard, T. Nawrot, H. Zhang, M. Bochud, T. Kuznetsova, T. Richart, L. M. Van Bortel, H. A. Struijker-Boudier, et al. Association Between Arterial Properties and Renal Sodium Handling in a General Population Hypertension, October 1, 2006; 48(4): 609 - 615. [Abstract] [Full Text] [PDF]

				M. E. Safar and P. Laurent Pulse pressure and arterial stiffness in rats: comparison with humans Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1363 - H1369. [Full Text] [PDF]

				K. Et-taouil, P. Schiavi, B. I. Levy, and G. E. Plante Sodium Intake, Large Artery Stiffness, and Proteoglycans in the Spontaneously Hypertensive Rat Hypertension, November 1, 2001; 38(5): 1172 - 1176. [Abstract] [Full Text] [PDF]

				O. Hanon, V. Luong, J. J. Mourad, L. A. Bortolotto, X. Jeunemaitre, and X. Girerd Aging, Carotid Artery Distensibility, and the Ser422Gly Elastin Gene Polymorphism in Humans Hypertension, November 1, 2001; 38(5): 1185 - 1189. [Abstract] [Full Text] [PDF]

				C. Labat, P. Lacolley, M. Lajemi, M. de Gasparo, M. E. Safar, and A. Benetos Effects of Valsartan on Mechanical Properties of the Carotid Artery in Spontaneously Hypertensive Rats Under High-Salt Diet Hypertension, September 1, 2001; 38(3): 439 - 443. [Abstract] [Full Text] [PDF]

				M.E Safar, C. Thuilliez, V Richard, and A Benetos Pressure-independent contribution of sodium to large artery structure and function in hypertension Cardiovasc Res, May 1, 2000; 46(2): 269 - 276. [Abstract] [Full Text] [PDF]

				M. E. Safar, G. M. London, R. Asmar, and E. D. Frohlich Recent Advances on Large Arteries in Hypertension Hypertension, July 1, 1998; 32(1): 156 - 161. [Abstract] [Full Text] [PDF]

				C. Partovian, A. Benetos, J.-P. Pommies, W. Mischler, and M. E. Safar Effects of a chronic high-salt diet on large artery structure: role of endogenous bradykinin Am J Physiol Heart Circ Physiol, May 1, 1998; 274(5): H1423 - H1428. [Abstract] [Full Text] [PDF]

				H. Hayakawa, K. Coffee, and L. Raij Endothelial Dysfunction and Cardiorenal Injury in Experimental Salt-Sensitive Hypertension : Effects of Antihypertensive Therapy Circulation, October 7, 1997; 96(7): 2407 - 2413. [Abstract] [Full Text]

				M. E. Safar and E. D. Frohlich The Arterial System in Hypertension : A Prospective View Hypertension, July 1, 1995; 26(1): 10 - 14. [Abstract] [Full Text]