(Hypertension. 1995;25:320-326.)
© 1995 American Heart Association, Inc.
Articles |
Association of the 
-Adducin Locus With Essential Hypertension
From the Division of Nephrology, Dialysis and Hypertension, University of Milan, S. Raffaele Hospital; Prassis-Sigma-Tau Research Institute, Settimo Milanese, Milan; the Blood Transfusion and Immunology of Transplantation Centre, Ospedale Maggiore Policlinico, Milan; the Department of Neuroscience, University of Milan, S. Raffaele Hospital; and the Department of Genetics and Microbiology, University of Milan (Italy).
Correspondence to Prof Giuseppe Bianchi, University of Milan, Division of Nephrology, Dialysis and Hypertension, S. Raffaele Hospital, via Olgettina 60, 20132 Milan, Italy.
Abstract Previous studies on genetic rat hypertension have
shown that polymorphism within the 
-adducin gene may regulate blood
pressure. Adducin is a cytoskeletal protein that may be involved in
cellular signal transduction and interacts with other membrane-skeleton
proteins that affect ion transport across the cell membrane. There is a
high homology between rat and human adducin and pathophysiological
similarities between the Milan hypertensive rat strain and a subgroup
of patients with essential hypertension. Thus, we designed a
case-control study to test the possible association between the
-adducin locus and hypertension. One hundred ninety primary
hypertensive patients were compared with 126 control subjects. All
subjects were white and unrelated. Four multiallelic markers
surrounding the -adducin locus located in 4p16.3 were selected:
D4S125 and D4S95 mapping at 680 and 20 kb centromeric, and D4S43 and
D4S228/E24 mapping at 660 and 2500 kb telomeric. Alleles for each
marker were pooled into groups. Comparisons between control subjects
and hypertensive patients were carried out by testing the
allele-disease association relative to the marker genotype. The maximal
association occurred for D4S95 (
12 13.33),
which maps closest to -adducin. These data suggest that a
polymorphism within the -adducin gene may affect blood pressure in
humans.
Key Words: case-control studies • hypertension, essential • polymorphism (genetics) • cytoskeleton • genes
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