(Hypertension. 1995;25:320-326.)
© 1995 American Heart Association, Inc.
Articles |
Association of the 
-Adducin Locus With Essential Hypertension
From the Division of Nephrology, Dialysis and Hypertension, University of Milan, S. Raffaele Hospital; Prassis-Sigma-Tau Research Institute, Settimo Milanese, Milan; the Blood Transfusion and Immunology of Transplantation Centre, Ospedale Maggiore Policlinico, Milan; the Department of Neuroscience, University of Milan, S. Raffaele Hospital; and the Department of Genetics and Microbiology, University of Milan (Italy).
Correspondence to Prof Giuseppe Bianchi, University of Milan, Division of Nephrology, Dialysis and Hypertension, S. Raffaele Hospital, via Olgettina 60, 20132 Milan, Italy.
Abstract Previous studies on genetic rat hypertension have
shown that polymorphism within the 
-adducin gene may regulate blood
pressure. Adducin is a cytoskeletal protein that may be involved in
cellular signal transduction and interacts with other membrane-skeleton
proteins that affect ion transport across the cell membrane. There is a
high homology between rat and human adducin and pathophysiological
similarities between the Milan hypertensive rat strain and a subgroup
of patients with essential hypertension. Thus, we designed a
case-control study to test the possible association between the
-adducin locus and hypertension. One hundred ninety primary
hypertensive patients were compared with 126 control subjects. All
subjects were white and unrelated. Four multiallelic markers
surrounding the -adducin locus located in 4p16.3 were selected:
D4S125 and D4S95 mapping at 680 and 20 kb centromeric, and D4S43 and
D4S228/E24 mapping at 660 and 2500 kb telomeric. Alleles for each
marker were pooled into groups. Comparisons between control subjects
and hypertensive patients were carried out by testing the
allele-disease association relative to the marker genotype. The maximal
association occurred for D4S95 (
12 13.33),
which maps closest to -adducin. These data suggest that a
polymorphism within the -adducin gene may affect blood pressure in
humans.
Key Words: case-control studies • hypertension, essential • polymorphism (genetics) • cytoskeleton • genes
This article has been cited by other articles:
 |
|
 |
|
  L. Torielli, S. Tivodar, R. C. Montella, R. Iacone, G. Padoani, P. Tarsini, O. Russo, D. Sarnataro, P. Strazzullo, P. Ferrari, et al. {alpha}-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption Am J Physiol Renal Physiol, August 1, 2008; 295(2): F478 - F487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hadtstein and F. Schaefer What adult nephrologists should know about childhood blood pressure Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2119 - 2123. [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Wang, I. Armando, L. D. Asico, C. Escano, X. Wang, Q. Lu, R. A. Felder, C. G. Schnackenberg, D. R. Sibley, G. M. Eisner, et al. The elevated blood pressure of human GRK4{gamma} A142V transgenic mice is not associated with increased ROS production Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2083 - H2092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferrari, M. Ferrandi, G. Valentini, and G. Bianchi Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R529 - R535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Neve Novel Features of G Protein-Coupled Receptor Kinase 4 Mol. Pharmacol., March 1, 2006; 69(3): 673 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, L. D. Asico, P. Yu, Z. Wang, J. E. Jones, C. S. Escano, X. Wang, M. T. Quinn, D. R. Sibley, G. G. Romero, et al. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R96 - R104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bianchi Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1536 - R1549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases Physiol Rev, April 1, 2005; 85(2): 679 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose Functional genomics of the dopaminergic system in hypertension Physiol Genomics, November 17, 2004; 19(3): 233 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W J Yang, J F Huang, C L Yao, Z J Fan, D L Ge, W Q Gan, G Y Huang, R T Hui, Y Shen, B Q Qiang, et al. Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families J. Med. Genet., May 1, 2003; 40(5): e57 - 57. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Strazzullo, F. Galletti, and G. Barba Altered Renal Handling of Sodium in Human Hypertension: Short Review of the Evidence Hypertension, May 1, 2003; 41(5): 1000 - 1005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Barlassina, C. Lanzani, P. Manunta, and G. Bianchi Genetics of Essential Hypertension: From Families to Genes J. Am. Soc. Nephrol., November 1, 2002; 13(90003): S155 - 164. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Mulatero, T. A. Williams, A. Milan, C. Paglieri, F. Rabbia, F. Fallo, and F. Veglio Blood Pressure in Patients with Primary Aldosteronism Is Influenced by Bradykinin B2 Receptor and {alpha}-Adducin Gene Polymorphisms J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3337 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Felder, H. Sanada, J. Xu, P.-Y. Yu, Z. Wang, H. Watanabe, L. D. Asico, W. Wang, S. Zheng, I. Yamaguchi, et al. G protein-coupled receptor kinase 4 gene variants in human essential hypertension PNAS, March 19, 2002; 99(6): 3872 - 3877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Grant, J. R. Romero, X. Jeunemaitre, S. C. Hunt, P. N. Hopkins, N. H. Hollenberg, and G. H. Williams Low-Renin Hypertension, Altered Sodium Homeostasis, and an {alpha}-Adducin Polymorphism Hypertension, February 1, 2002; 39(2): 191 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Glenn, W. F. Stewart, B. S. Schwartz, and J. Bressler Relation of Alleles of the Sodium-Potassium Adenosine Triphosphatase {{alpha}}2 Gene with Blood Pressure and Lead Exposure Am. J. Epidemiol., March 15, 2001; 153(6): 537 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Larson, R. Hutchinson, and E. Boerwinkle Lack of Association of 3 Functional Gene Variants With Hypertension in African Americans Hypertension, June 1, 2000; 35(6): 1297 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stoll, A. E. Kwitek-Black, A. W. Cowley Jr., E. L. Harris, S. B. Harrap, J. E. Krieger, M. P. Printz, A. P. Provoost, J. Sassard, and H. J. Jacob New Target Regions for Human Hypertension via Comparative Genomics Genome Res., April 1, 2000; 10(4): 473 - 482. [Abstract] [Full Text]
|
|
|
|
|
|
M. Ferrandi, S. Salardi, G. Tripodi, P. Barassi, R. Rivera, P. Manunta, R. Goldshleger, P. Ferrari, G. Bianchi, and S. J. D. Karlish Evidence for an interaction between adducin and Na+-K+-ATPase: relation to genetic hypertension Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1338 - H1349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Glorioso, P. Manunta, F. Filigheddu, C. Troffa, P. Stella, C. Barlassina, C. Lombardi, A. Soro, F. Dettori, P. P. Parpaglia, et al. The Role of {alpha}-Adducin Polymorphism in Blood Pressure and Sodium Handling Regulation May Not Be Excluded by a Negative Association Study Hypertension, October 1, 1999; 34(4): 649 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferrari, M. Ferrandi, G. Tripodi, L. Torielli, G. Padoani, E. Minotti, P. Melloni, and G. Bianchi PST 2238: A New Antihypertensive Compound that Modulates Na,K-ATPase in Genetic Hypertension J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 1074 - 1083. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kamitani, Z. Y. H. Wong, R. Fraser, D. L. Davies, J. M. Connor, C. J. W. Foy, G. C. M. Watt, and S. B. Harrap Human {alpha}-Adducin Gene, Blood Pressure, and Sodium Metabolism Hypertension, July 1, 1998; 32(1): 138 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kato, T. Sugiyama, T. Nabika, H. Morita, H. Kurihara, Y. Yazaki, and Y. Yamori Lack of Association Between the {alpha}-Adducin Locus and Essential Hypertension in the Japanese Population Hypertension, March 1, 1998; 31(3): 730 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. HALUSHKA, D. J. MATHEWS, J. A. BAILEY, and A. CHAKRAVARTI GIST: A web tool for collecting gene information Physiol Genomics, August 31, 1999; 1(2): 75 - 81. [Abstract] [Full Text] [PDF]
|
|