This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shimamoto, H. Articles by Shimamoto, Y. Search for Related Content PubMed PubMed Citation Articles by Shimamoto, H. Articles by Shimamoto, Y. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information High Blood Pressure Hazardous Substances DB LISINOPRIL

(Hypertension. 1995;25:327-334.)
© 1995 American Heart Association, Inc.

Articles

Lisinopril Improves Aortic Compliance and Renal Flow

Comparison With Nifedipine

Hiroyuki Shimamoto; Yoriko Shimamoto

From the Department of Cardiovascular Medicine, PIA Nakamura Hospital, Hiroshima, Japan.

Correspondence to Hiroyuki Shimamoto, MD, 2-24-1, Koi-Higashi, Nishi-ku, Hiroshima 733, Japan.

Abstract We compared the systemic and regional hemodynamic effects of nifedipine and lisinopril in 26 elderly hypertensive patients with the use of the pulsed Doppler ultrasound technique. Nifedipine is a dihydropyridine calcium antagonist, and lisinopril is an angiotensin-converting enzyme inhibitor. The study had a single-blind crossover design: nifedipine and lisinopril were given for 8 weeks each after washout periods of 4 weeks. Both nifedipine and lisinopril significantly reduced mean arterial pressure to the same extent (P<.01); cardiac output remained unchanged in both nifedipine- and lisinopril-treated groups. Lisinopril increased renal flow significantly (P<.01), but nifedipine did not. Common carotid, vertebral, celiac, and superior mesenteric arterial and diaphragmatic and terminal aortic flows did not show a significant change with either nifedipine or lisinopril. The specific action of lisinopril on the thoracic aorta was a marked improvement of aortic compliance compared with nifedipine, which might be partly responsible for an increase in renal flow. Lisinopril may provide more desirable regional hemodynamic effects and additional benefits for elderly hypertensive patients.

Key Words: nifedipine • hemodynamics • Doppler flowmetry • compliance

This article has been cited by other articles:

				A. A. Ahimastos, A. K. Natoli, A. Lawler, P. A. Blombery, and B. A. Kingwell Ramipril Reduces Large-Artery Stiffness in Peripheral Arterial Disease and Promotes Elastogenic Remodeling in Cell Culture Hypertension, June 1, 2005; 45(6): 1194 - 1199. [Abstract] [Full Text] [PDF]

				A. Smith, J. Karalliedde, L. De Angelis, D. Goldsmith, and G. Viberti Aortic Pulse Wave Velocity and Albuminuria in Patients with Type 2 Diabetes J. Am. Soc. Nephrol., April 1, 2005; 16(4): 1069 - 1075. [Abstract] [Full Text] [PDF]

				J. J. Oliver and D. J. Webb Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events Arterioscler. Thromb. Vasc. Biol., April 1, 2003; 23(4): 554 - 566. [Abstract] [Full Text] [PDF]

				A. M. Dart and B. A. Kingwell Pulse pressure--a review of mechanisms and clinical relevance J. Am. Coll. Cardiol., March 15, 2001; 37(4): 975 - 984. [Abstract] [Full Text] [PDF]

				P. Boutouyrie, C. Bussy, D. Hayoz, J. Hengstler, N. Dartois, B. Laloux, H. Brunner, and S. Laurent Local Pulse Pressure and Regression of Arterial Wall Hypertrophy During Long-Term Antihypertensive Treatment Circulation, June 6, 2000; 101(22): 2601 - 2606. [Abstract] [Full Text] [PDF]

				M. J. Domanski, G. F. Mitchell, J. E. Norman, D. V. Exner, B. Pitt, and M. A. Pfeffer Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction J. Am. Coll. Cardiol., March 15, 1999; 33(4): 951 - 958. [Abstract] [Full Text] [PDF]

				G. F. Mitchell, L. A. Moye, E. Braunwald, J.-L. Rouleau, V. Bernstein, E. M. Geltman, G. C. Flaker, M. A. Pfeffer, and f. t. S. Investigators Sphygmomanometrically Determined Pulse Pressure Is a Powerful Independent Predictor of Recurrent Events After Myocardial Infarction in Patients With Impaired Left Ventricular Function Circulation, December 16, 1997; 96(12): 4254 - 4260. [Abstract] [Full Text]

				A. Benetos, F. Cambien, S. Gautier, S. Ricard, M. Safar, S. Laurent, P. Lacolley, O. Poirier, J. Topouchian, and R. Asmar Influence of the Angiotensin II Type 1 Receptor Gene Polymorphism on the Effects of Perindopril and Nitrendipine on Arterial Stiffness in Hypertensive Individuals Hypertension, December 1, 1996; 28(6): 1081 - 1084. [Abstract] [Full Text]

				H. Shimamoto and Y. Shimamoto Lisinopril Reverses Left Ventricular Hypertrophy Through Improved Aortic Compliance Hypertension, September 1, 1996; 28(3): 457 - 463. [Abstract] [Full Text]

				K. Skov, J. Fenger-Gron, and M. J. Mulvany Effects of an Angiotensin-Converting Enzyme Inhibitor, a Calcium Antagonist, and an Endothelin Receptor Antagonist on Renal Afferent Arteriolar Structure Hypertension, September 1, 1996; 28(3): 464 - 471. [Abstract] [Full Text]

				A. Benetos, S. Gautier, S. Ricard, J. Topouchian, R. Asmar, O. Poirier, E. Larosa, L. Guize, M. Safar, F. Soubrier, et al. Influence of Angiotensin-Converting Enzyme and Angiotensin II Type 1 Receptor Gene Polymorphisms on Aortic Stiffness in Normotensive and Hypertensive Patients Circulation, August 15, 1996; 94(4): 698 - 703. [Abstract] [Full Text]

				M. Notoya, M. Nakamura, and K. Mizojiri Effects of Lisinopril on the Structure of Renal Arterioles Hypertension, March 1, 1996; 27(3): 364 - 370. [Abstract] [Full Text]