This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by D'Amico, M. Articles by Rossi, F. Search for Related Content PubMed PubMed Citation Articles by D'Amico, M. Articles by Rossi, F.

(Hypertension. 1995;25:507-510.)
© 1995 American Heart Association, Inc.

Articles

Endothelin-1 in Rat Periaqueductal Gray Area Induces Hypertension Via Glutamatergic Receptors

Michele D'Amico; Liberato Berrino; Sabatino Maione; Amelia Filippelli; Anna Pizzirusso; Saverio Vitagliano; Francesco Rossi

From the Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples (Italy).

Correspondence to Dr Liberato Berrino, Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy.

Abstract We investigated the possible relationship between endothelin-1 injection into the dorsolateral periaqueductal gray area and the glutamatergic system in the control of cardiovascular function. Endothelin-1 was injected into the dorsolateral periaqueductal gray area of freely moving rats at doses ranging from 0.1 to 10 pmol. Endothelin-1 increased arterial blood pressure (from 7.0±1.6 to 55.0±4.1 mm Hg, mean±SEM) in a dose-dependent manner and induced characteristic behavioral changes such as longitudinal rolling of the body (barrel-rolling). DL-2-Amino-5-phosphonovaleric acid and (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[D-]cyclohepten-5,10-imine hydrogen maleate, both selective N-methyl-D-aspartate excitatory amino acid receptor antagonists, but not 6-cyano-7-nitroquinoxaline-2,3-dione, a non–N-methyl-D-aspartate excitatory amino acid receptor antagonist, significantly decreased endothelin-1–induced cardiovascular and behavioral changes (P<.01). Prazosin and propranolol, adrenergic blocking agents, and reserpine, a depletor of catecholamine stores, also prevented these effects. We propose that the glutamatergic system may exert, via N-methyl-D-aspartate receptors, a significant influence on endothelin-1–induced cardiovascular and behavioral effects after its injection into the periaqueductal area.

Key Words: receptors, N-methyl-D-aspartate • rats • endothelins • periaqueductal gray • hypertension, experimental

This article has been cited by other articles:

				Y. Liu, E.-S. Ji, S. Xiang, R. Tamisier, J. Tong, J. Huang, and J. W. Weiss Exposure to cyclic intermittent hypoxia increases expression of functional NMDA receptors in the rat carotid body J Appl Physiol, January 1, 2009; 106(1): 259 - 267. [Abstract] [Full Text] [PDF]

				M. Shihara, Y. Hirooka, N. Hori, I. Matsuo, T. Tagawa, S. Suzuki, N. Akaike, and A. Takeshita Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R658 - R665. [Abstract] [Full Text] [PDF]