(Hypertension. 1995;25:1058-1068.)
© 1995 American Heart Association, Inc.
Articles |
Spontaneous Cardiac Baroreflex in Humans
Comparison With Drug-Induced Responses
From the Laboratoire de Physiologie de l'Environnement (CNRA SDI 6100 and URA 1341) and Département d'Anesthésie, Faculté de Médecine Grange Blanche and Hôpital Edouard Herriot, Lyon, France; and the Department of Kinesiology, University of Waterloo (Ontario, Canada).
Abstract We compared two methods of assessment of baroreflex sensitivity in eight supine healthy volunteers during repeated baseline measurements and various conditions of cardiac autonomic blockade. The spontaneous baroreflex method involved computer scanning of recordings of continuous finger arterial pressure and electrocardiogram to locate sequences of three or more beats in which pressure spontaneously increased or decreased, with parallel changes in pulse intervals. The mean regression slope of all these sequences during each study condition was considered to represent the mean spontaneous baroreflex slope. In the drug-induced method, sigmoidal curves were constructed from data obtained by bolus injections of phenylephrine and nitroprusside; the tangents taken at the resting pressure of each of these curves were compared with the mean spontaneous baroreflex slopes. The two methods yielded slopes that were highly correlated (r=.96, P<.001), with significant but similar intraindividual baseline variability. Atropine virtually eliminated the baroreflex slope; subsequent addition of propranolol did not alter it further. Propranolol or clonidine alone increased average baroreflex slope to the extent that they increased resting pulse interval (r=.69 to .83). The spontaneous baroreflex method provides a reliable, noninvasive assessment of human vagal cardiac baroreflex sensitivity within its physiological operating range.
Key Words: pressoreceptors • blood pressure • heart rate • autonomic nervous system • clonidine • atropine • propranolol
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