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(Hypertension. 1995;25:1111-1115.)
© 1995 American Heart Association, Inc.


Articles

A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice

John H. Krege; Jeffrey B. Hodgin; John R. Hagaman; Oliver Smithies

From the Departments of Pathology and Medicine, University of North Carolina at Chapel Hill.

Correspondence to Dr John H. Krege, 703 B.B.B., CB #7525, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. E-mail krege@med.unc.edu.

Abstract We have validated a noninvasive computerized tail-cuff system for measuring blood pressure in mice. The system was designed to perform all functions automatically, including a programmable routine of cuff inflation and deflation, analysis and assignment of pulse rate and blood pressure, and recording of data electronically. To evaluate this system over a range of blood pressures, we gave groups of mice enalapril or NG-nitro-L-arginine methyl ester in their drinking water. For each of these groups, an equal number of control mice were given nothing in their drinking water. Tail-cuff blood pressures were recorded as the means of blood pressures determined on at least 3 days after at least 7 days of training. Tail-cuff enalapril and control group means were measured both 3 and 4 months after enalapril (or no drug) was begun; the group means at 3 months were not significantly different from the group means at 4 months. These results demonstrate that the system gives reproducible results. After the tail-cuff measurements were completed, intra-arterial blood pressures were attempted in all mice under unrestrained, unanesthetized conditions, and individual mouse (n=22) blood pressures with the use of the two methods were compared. The blood pressures from individual mice by tail-cuff and intra-arterial methods were highly correlated (r=.86, P<.01). The means for the four mouse groups were also highly correlated (r=.98, P<.02). These data show that blood pressures measured on trained mice by a computerized noninvasive tail-cuff system are reproducible and correlate well with intra-arterial blood pressures measured on unrestrained, unanesthetized mice.


Key Words: blood pressure determination, noninvasive • genetics • mice




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J. Appl. Physiol.Home page
C. F. Deschepper, J. L. Olson, M. Otis, and N. Gallo-Payet
Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains
J Appl Physiol, July 1, 2004; 97(1): 369 - 376.
[Abstract] [Full Text] [PDF]


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DiabetesHome page
J. M. Forbes, L. T. L. Yee, V. Thallas, M. Lassila, R. Candido, K. A. Jandeleit-Dahm, M. C. Thomas, W. C. Burns, E. K. Deemer, S. R. Thorpe, et al.
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
Diabetes, July 1, 2004; 53(7): 1813 - 1823.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
S. E. Whitesall, J. B. Hoff, A. P. Vollmer, and L. G. D'Alecy
Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2408 - H2415.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
M. Lassila, T. J. Allen, Z. Cao, V. Thallas, K. A. Jandeleit-Dahm, R. Candido, and M. E. Cooper
Imatinib Attenuates Diabetes-Associated Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 935 - 942.
[Abstract] [Full Text]


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J. Biol. Chem.Home page
S. Fuchs, H. D. Xiao, J. M. Cole, J. W. Adams, K. Frenzel, A. Michaud, H. Zhao, G. Keshelava, M. R. Capecchi, P. Corvol, et al.
Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice
J. Biol. Chem., April 16, 2004; 279(16): 15946 - 15953.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
K. M. I. Caron, L. R. James, H.-S. Kim, J. Knowles, R. Uhlir, L. Mao, J. R. Hagaman, W. Cascio, H. Rockman, and O. Smithies
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
PNAS, March 2, 2004; 101(9): 3106 - 3111.
[Abstract] [Full Text] [PDF]


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CirculationHome page
A. Paul, K. W.S. Ko, L. Li, V. Yechoor, M. A. McCrory, A. J. Szalai, and L. Chan
C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
Circulation, February 10, 2004; 109(5): 647 - 655.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
T. H. Le, A. B. Fogo, H. R. Salzler, T. Vinogradova, M. I. Oliverio, D. A. Marchuk, and T. M. Coffman
Modifier Locus on Mouse Chromosome 3 for Renal Vascular Pathology in AT1A Receptor-Deficiency
Hypertension, February 1, 2004; 43(2): 445 - 451.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
B. Moreno-Lopez, C. Romero-Grimaldi, J. A. Noval, M. Murillo-Carretero, E. R. Matarredona, and C. Estrada
Nitric Oxide Is a Physiological Inhibitor of Neurogenesis in the Adult Mouse Subventricular Zone and Olfactory Bulb
J. Neurosci., January 7, 2004; 24(1): 85 - 95.
[Abstract] [Full Text] [PDF]


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CirculationHome page
H. Dayoub, V. Achan, S. Adimoolam, J. Jacobi, M. C. Stuehlinger, B.-y. Wang, P. S. Tsao, M. Kimoto, P. Vallance, A. J. Patterson, et al.
Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological Evidence
Circulation, December 16, 2003; 108(24): 3042 - 3047.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
A. Zahabi, S. Picard, N. Fortin, T. L. Reudelhuber, and C. F. Deschepper
Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts
J. Biol. Chem., November 28, 2003; 278(48): 47694 - 47699.
[Abstract] [Full Text] [PDF]


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Physiol. GenomicsHome page
D. D. L. Woo and I. Kurtz
Mapping blood pressure loci in (A/J x B6)F2 mice
Physiol Genomics, November 11, 2003; 15(3): 236 - 242.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
K. Kazama, G. Wang, K. Frys, J. Anrather, and C. Iadecola
Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex
Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1890 - H1899.
[Abstract] [Full Text] [PDF]


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J. Am. Soc. Nephrol.Home page
S. Bro, J. F. Bentzon, E. Falk, C. B. Andersen, K. Olgaard, and L. B. Nielsen
Chronic Renal Failure Accelerates Atherogenesis in Apolipoprotein E-Deficient Mice
J. Am. Soc. Nephrol., October 1, 2003; 14(10): 2466 - 2474.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
T. H. Le, H.-S. Kim, A. M. Allen, R. F. Spurney, O. Smithies, and T. M. Coffman
Physiological Impact of Increased Expression of the AT1 Angiotensin Receptor
Hypertension, October 1, 2003; 42(4): 507 - 514.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
M. S. Taylor, A. D. Bonev, T. P. Gross, D. M. Eckman, J. E. Brayden, C. T. Bond, J. P. Adelman, and M. T. Nelson
Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure
Circ. Res., July 25, 2003; 93(2): 124 - 131.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
C. R. Hampton, A. Shimamoto, C. L. Rothnie, J. Griscavage-Ennis, A. Chong, D. J. Dix, E. D. Verrier, and T. H. Pohlman
HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H866 - H874.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
N. Takahashi, J. R. Hagaman, H.-S. Kim, and O. Smithies
Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin System
Endocrinology, June 1, 2003; 144(6): 2184 - 2190.
[Abstract] [Full Text] [PDF]


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Arterioscler. Thromb. Vasc. Bio.Home page
M. R. Alexander, J. W. Knowles, T. Nishikimi, and N. Maeda
Increased Atherosclerosis and Smooth Muscle Cell Hypertrophy in Natriuretic Peptide Receptor A-/-Apolipoprotein E-/- Mice
Arterioscler. Thromb. Vasc. Biol., June 1, 2003; 23(6): 1077 - 1082.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. P. Kessler, P. deS. Senanayake, T. S. Scheidemantel, J. B. Gomos, T. M. Rowe, and G. C. Sen
Maintenance of Normal Blood Pressure and Renal Functions Are Independent Effects of Angiotensin-converting Enzyme
J. Biol. Chem., May 30, 2003; 278(23): 21105 - 21112.
[Abstract] [Full Text] [PDF]


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Physiol. GenomicsHome page
K. Kramer and L. B. Kinter
Evaluation and applications of radiotelemetry in small laboratory animals
Physiol Genomics, May 13, 2003; 13(3): 197 - 205.
[Abstract] [Full Text] [PDF]


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J. Appl. Physiol.Home page
K. L. Svenson, M. A. Bogue, and L. L. Peters
Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains
J Appl Physiol, April 1, 2003; 94(4): 1650 - 1659.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
V. Gross and F. C. Luft
Exercising Restraint in Measuring Blood Pressure in Conscious Mice
Hypertension, April 1, 2003; 41(4): 879 - 881.
[Full Text] [PDF]


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HypertensionHome page
J. M. Cole, N. Khokhlova, R. L. Sutliff, J. W. Adams, K. M. Disher, H. Zhao, M. R. Capecchi, P. Corvol, and K. E. Bernstein
Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II
Hypertension, February 1, 2003; 41(2): 313 - 321.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
N. Lochard, D. W. Silversides, J. P. van Kats, C. Mercure, and T. L. Reudelhuber
Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice
J. Biol. Chem., January 17, 2003; 278(4): 2184 - 2189.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. Meyer, M. Flagella, R. L. Sutliff, J. N. Lorenz, M. L. Nieman, C. S. Weber, R. J. Paul, and G. E. Shull
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl- cotransporter
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1846 - H1855.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
S. P. Didion, M. J. Ryan, G. L. Baumbach, C. D. Sigmund, and F. M. Faraci
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen
Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1569 - H1576.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
U. Landmesser, H. Cai, S. Dikalov, L. McCann, J. Hwang, H. Jo, S. M. Holland, and D. G. Harrison
Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
Hypertension, October 1, 2002; 40(4): 511 - 515.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Renal Physiol.Home page
A. J. Mangrum, R. A. Gomez, and V. F. Norwood
Effects of AT1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake
Am J Physiol Renal Physiol, September 1, 2002; 283(3): F447 - F453.
[Abstract] [Full Text] [PDF]


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Physiol. GenomicsHome page
F. Sugiyama, G. A. Churchill, R. Li, L. J. M. Libby, T. Carver, K.-I. Yagami, S. W. M. John, and B. Paigen
QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice
Physiol Genomics, July 12, 2002; 10(1): 5 - 12.
[Abstract] [Full Text] [PDF]


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CirculationHome page
R. Candido, K. A. Jandeleit-Dahm, Z. Cao, S. P. Nesteroff;, W. C. Burns, S. M. Twigg, R. J. Dilley, M. E. Cooper, and T. J. Allen
Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice
Circulation, July 9, 2002; 106(2): 246 - 253.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
K. M. I. Caron, L. R. James, H.-S. Kim, S. G. Morham, M. L. S. S. Lopez, R. A. Gomez, T. L. Reudelhuber, and O. Smithies
A genetically clamped renin transgene for the induction of hypertension
PNAS, June 11, 2002; 99(12): 8248 - 8252.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen and J. F. M. Smits
Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1565 - R1582.
[Abstract] [Full Text] [PDF]


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J. Am. Soc. Nephrol.Home page
N. Takahashi, H. L. Brooks, J. B. Wade, W. Liu, Y. Kondo, S. Ito, M. A. Knepper, and O. Smithies
Posttranscriptional Compensation for Heterozygous Disruption of the Kidney-Specific NaK2Cl Cotransporter Gene
J. Am. Soc. Nephrol., March 1, 2002; 13(3): 604 - 610.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
A. Y. H. Wong, S. Kulandavelu, K. J. Whiteley, D. Qu, B. L. Langille, and S. L. Adamson
Maternal cardiovascular changes during pregnancy and postpartum in mice
Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H918 - H925.
[Abstract] [Full Text] [PDF]


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Vasc MedHome page
M. W Manning, L. A Cassis, J. Huang, S. J Szilvassy, and A. Daugherty
Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease
Vascular Medicine, February 1, 2002; 7(1): 45 - 54.
[Abstract] [PDF]