(Hypertension. 1995;25:1111-1115.)
© 1995 American Heart Association, Inc.
Articles |
A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice
From the Departments of Pathology and Medicine, University of North Carolina at Chapel Hill.
Correspondence to Dr John H. Krege, 703 B.B.B., CB #7525, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. E-mail krege@med.unc.edu.
Abstract We have validated a noninvasive computerized tail-cuff system for measuring blood pressure in mice. The system was designed to perform all functions automatically, including a programmable routine of cuff inflation and deflation, analysis and assignment of pulse rate and blood pressure, and recording of data electronically. To evaluate this system over a range of blood pressures, we gave groups of mice enalapril or NG-nitro-L-arginine methyl ester in their drinking water. For each of these groups, an equal number of control mice were given nothing in their drinking water. Tail-cuff blood pressures were recorded as the means of blood pressures determined on at least 3 days after at least 7 days of training. Tail-cuff enalapril and control group means were measured both 3 and 4 months after enalapril (or no drug) was begun; the group means at 3 months were not significantly different from the group means at 4 months. These results demonstrate that the system gives reproducible results. After the tail-cuff measurements were completed, intra-arterial blood pressures were attempted in all mice under unrestrained, unanesthetized conditions, and individual mouse (n=22) blood pressures with the use of the two methods were compared. The blood pressures from individual mice by tail-cuff and intra-arterial methods were highly correlated (r=.86, P<.01). The means for the four mouse groups were also highly correlated (r=.98, P<.02). These data show that blood pressures measured on trained mice by a computerized noninvasive tail-cuff system are reproducible and correlate well with intra-arterial blood pressures measured on unrestrained, unanesthetized mice.
Key Words: blood pressure determination, noninvasive • genetics • mice
This article has been cited by other articles:
 |
|
 |
|
  J. Xu, O. A. Carretero, E. G. Shesely, N.-E. Rhaleb, J. J. Yang, M. Bader, and X.-P. Yang The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice Exp Physiol, March 1, 2009; 94(3): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Bradshaw, C. F. Baicu, T. J. Rentz, A. O. Van Laer, J. Boggs, J. M. Lacy, and M. R. Zile Pressure Overload-Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function: Role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in Post-Synthetic Procollagen Processing Circulation, January 20, 2009; 119(2): 269 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Athirakul, J. A. Bradbury, J. P. Graves, L. M. DeGraff, J. Ma, Y. Zhao, J. F. Couse, R. Quigley, D. R. Harder, X. Zhao, et al. Increased blood pressure in mice lacking cytochrome P450 2J5 FASEB J, December 1, 2008; 22(12): 4096 - 4108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ebrahimian, M. R. Sairam, E. L. Schiffrin, and R. M. Touyz Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1481 - H1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Francois, N. Makhanova, P. Ruiz, J. Ellison, L. Mao, H. A. Rockman, and T. M. Coffman A role for the thromboxane receptor in L-NAME hypertension Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1096 - F1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vilar, L. Waeckel, P. Bonnin, C. Cochain, C. Loinard, M. Duriez, J.-S. Silvestre, and B. I. Levy Chronic Hypoxia-Induced Angiogenesis Normalizes Blood Pressure in Spontaneously Hypertensive Rats Circ. Res., September 26, 2008; 103(7): 761 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Y. Szeto, A. Aziz, P. J. Das, A. Y. Taha, N. Okubo, S. Reza-Lopez, A. Giacca, and G. H. Anderson High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R575 - R582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-D. Liao, X.-P. Yang, Y.-H. Liu, E. G. Shesely, M. A. Cavasin, W. A. Kuziel, P. J. Pagano, and O. A. Carretero Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II-Induced Hypertension Hypertension, August 1, 2008; 52(2): 256 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Buys, P. Sips, P. Vermeersch, M. J. Raher, E. Rogge, F. Ichinose, M. Dewerchin, K. D. Bloch, S. Janssens, and P. Brouckaert Gender-specific hypertension and responsiveness to nitric oxide in sGC{alpha}1 knockout mice Cardiovasc Res, July 1, 2008; 79(1): 179 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Machado, E. P. B. Poppi, C. Fanelli, D. M. A. C. Malheiros, R. Zatz, and C. K. Fujihara AT1 blockade during lactation as a model of chronic nephropathy: mechanisms of renal injury Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1345 - F1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duka, E. Kintsurashvili, I. Duka, D. Ona, T. A. Hopkins, M. Bader, I. Gavras, and H. Gavras Angiotensin-Converting Enzyme Inhibition After Experimental Myocardial Infarct: Role of the Kinin B1 and B2 Receptors Hypertension, May 1, 2008; 51(5): 1352 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Vinge, T. G. von Lueder, E. Aasum, E. Qvigstad, J. A. Gravning, O.-J. How, T. Edvardsen, R. Bjornerheim, M. S. Ahmed, B. W. Mikkelsen, et al. Cardiac-restricted Expression of the Carboxyl-terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth: GRK3 CONTROLS CARDIAC {alpha}1-ADRENERGIC RECEPTOR RESPONSIVENESS J. Biol. Chem., April 18, 2008; 283(16): 10601 - 10610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Elahi, F. R. Cagampang, F. W. Anthony, N. Curzen, S. K. Ohri, and M. A. Hanson Statin Treatment in Hypercholesterolemic Pregnant Mice Reduces Cardiovascular Risk Factors in Their Offspring Hypertension, April 1, 2008; 51(4): 939 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Coffman and S. D. Crowley Kidney in Hypertension: Guyton Redux Hypertension, April 1, 2008; 51(4): 811 - 816. [Full Text] [PDF]
|
|
|
|
|
|
K. Tsukuda, M. Mogi, J.-M. Li, J. Iwanami, L.-J. Min, A. Sakata, T. Fujita, M. Iwai, and M. Horiuchi Diabetes-Associated Cognitive Impairment Is Improved by a Calcium Channel Blocker, Nifedipine Hypertension, February 1, 2008; 51(2): 528 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tsukuda, M. Mogi, J.-M. Li, J. Iwanami, L.-J. Min, A. Sakata, T. Fujita, M. Iwai, and M. Horiuchi Amelioration of Cognitive Impairment in the Type-2 Diabetic Mouse by the Angiotensin II Type-1 Receptor Blocker Candesartan Hypertension, December 1, 2007; 50(6): 1099 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, O. A. Carretero, C.-X. Lin, M. A. Cavasin, E. G. Shesely, J. J. Yang, T. L. Reudelhuber, and X.-P. Yang Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1900 - H1907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. LeBrasseur, T.-A. S. Duhaney, D. S. De Silva, L. Cui, P. C. Ip, L. Joseph, and F. Sam Effects of Fenofibrate on Cardiac Remodeling in Aldosterone-Induced Hypertension Hypertension, September 1, 2007; 50(3): 489 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhao, E. Vellaichamy, N. K. Somanna, and K. N. Pandey Guanylyl cyclase/natriuretic peptide receptor-A gene disruption causes increased adrenal angiotensin II and aldosterone levels Am J Physiol Renal Physiol, July 1, 2007; 293(1): F121 - F127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dackor, K. Fritz-Six, O. Smithies, and K. Caron Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age J. Biol. Chem., June 22, 2007; 282(25): 18094 - 18099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Fujihara, D. M. A. C. Malheiros, and R. Zatz Losartan-hydrochlorothiazide association promotes lasting blood pressure normalization and completely arrests long-term renal injury in the 5/6 ablation model Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1810 - F1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kakoki, R. W. McGarrah, H.-S. Kim, and O. Smithies Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury PNAS, May 1, 2007; 104(18): 7576 - 7581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-A. S. Duhaney, L. Cui, M. K. Rude, N. K. Lebrasseur, S. Ngoy, D. S. De Silva, D. A. Siwik, R. Liao, and F. Sam Peroxisome Proliferator-Activated Receptor {alpha}-Independent Actions of Fenofibrate Exacerbates Left Ventricular Dilation and Fibrosis in Chronic Pressure Overload Hypertension, May 1, 2007; 49(5): 1084 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stoyanova, M. Trudel, H. Felfly, D. Garcia, and G. Cloutier Characterization of circulatory disorders in {beta}-thalassemic mice by noninvasive ultrasound biomicroscopy Physiol Genomics, March 14, 2007; 29(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Caron, J. Hagaman, T. Nishikimi, H.-S. Kim, and O. Smithies Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males PNAS, February 27, 2007; 104(9): 3420 - 3425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-Y. Chang, E. Parker, M. El Nahas, J. L. Haylor, and A. C.M. Ong Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease J. Am. Soc. Nephrol., February 1, 2007; 18(2): 560 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hua, M. Kovarova, K. D. Chason, M. Nguyen, B. H. Koller, and S. L. Tilley Enhanced mast cell activation in mice deficient in the A2b adenosine receptor J. Exp. Med., January 22, 2007; 204(1): 117 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Kessler, P. deS. Senanayake, C. Gaughan, and G. C. Sen Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE-/- mice FASEB J, January 1, 2007; 21(1): 156 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramchandran, T. Takezako, Y. Saad, L. Stull, B. Fink, H. Yamada, S. Dikalov, D. G. Harrison, C. Moravec, and S. S. Karnik Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response PNAS, December 12, 2006; 103(50): 19087 - 19092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Makhanova, M. L.S. Sequeira-Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption Hypertension, December 1, 2006; 48(6): 1151 - 1159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chansel, M. Ciroldi, S. Vandermeersch, L. F Jackson, A.-M. Gomez, D. Henrion, D. C. Lee, T. M. Coffman, S. Richard, J.-C. Dussaule, et al. Heparin binding EGF is necessary for vasospastic response to endothelin FASEB J, September 1, 2006; 20(11): 1936 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miriyala, M. C. Gongora Nieto, C. Mingone, D. Smith, S. Dikalov, D. G. Harrison, and H. Jo Bone Morphogenic Protein-4 Induces Hypertension in Mice: Role of Noggin, Vascular NADPH Oxidases, and Impaired Vasorelaxation Circulation, June 20, 2006; 113(24): 2818 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Karuri, Y. Huang, S. Bodreddigari, C. H. Sutter, B. D. Roebuck, T. W. Kensler, and T. R. Sutter 3H-1,2-Dithiole-3-thione Targets Nuclear Factor {kappa}B to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 61 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsusaka, T. Ide, S. Matsushima, M. Ikeuchi, T. Kubota, K. Sunagawa, S. Kinugawa, and H. Tsutsui Targeted Deletion of Matrix Metalloproteinase 2 Ameliorates Myocardial Remodeling in Mice With Chronic Pressure Overload Hypertension, April 1, 2006; 47(4): 711 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ye, H. Zhang, E. Hillas, D. E. Kohan, R. L. Miller, R. D. Nelson, M. Honeggar, and T. Yang Expression and function of COX isoforms in renal medulla: evidence for regulation of salt sensitivity and blood pressure Am J Physiol Renal Physiol, February 1, 2006; 290(2): F542 - F549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Makhanova, G. Lee, N. Takahashi, M. L. Sequeira Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies Kidney function in mice lacking aldosterone Am J Physiol Renal Physiol, January 1, 2006; 290(1): F61 - F69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Gurley, S. E. Clare, K. P. Snow, A. Hu, T. W. Meyer, and T. M. Coffman Impact of genetic background on nephropathy in diabetic mice Am J Physiol Renal Physiol, January 1, 2006; 290(1): F214 - F222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Liu, O. A. Carretero, O. H. Cingolani, T.-D. Liao, Y. Sun, J. Xu, L. Y. Li, P. J. Pagano, J. J. Yang, and X.-P. Yang Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2616 - H2623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Predescu, S. Predescu, J. Shimizu, K. Miyawaki-Shimizu, and A. B. Malik Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L371 - L381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Schmelzer, L. Kubala, J. W. Newman, I.-H. Kim, J. P. Eiserich, and B. D. Hammock Soluble epoxide hydrolase is a therapeutic target for acute inflammation PNAS, July 12, 2005; 102(28): 9772 - 9777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lee, N. Makhanova, K. Caron, M. L. S. Lopez, R. A. Gomez, O. Smithies, and H.-S. Kim Homeostatic Responses in the Adrenal Cortex to the Absence of Aldosterone in Mice Endocrinology, June 1, 2005; 146(6): 2650 - 2656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yang, Y. G. Huang, W. Ye, P. Hansen, J. B. Schnermann, and J. P. Briggs Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1125 - F1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Freedman, E.-J. Lee, Y. Park, and J. L. Jameson A Dominant Negative Peroxisome Proliferator-activated Receptor-{gamma} Knock-in Mouse Exhibits Features of the Metabolic Syndrome J. Biol. Chem., April 29, 2005; 280(17): 17118 - 17125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishikimi, J. R. Hagaman, N. Takahashi, H.-S. Kim, H. Matsuoka, O. Smithies, and N. Maeda Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene Cardiovasc Res, April 1, 2005; 66(1): 94 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-G. Jia, C. Donnet, R. C. Bogaev, R. J. Blatt, C. E. McKinney, K. H. Day, S. S. Berr, L. R. Jones, J. R. Moorman, K. J. Sweadner, et al. Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1982 - H1988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, O. A. Carretero, Y. Sun, E. G. Shesely, N.-E. Rhaleb, Y.-H. Liu, T.-D. Liao, J. J. Yang, M. Bader, and X.-P. Yang Role of the B1 Kinin Receptor in the Regulation of Cardiac Function and Remodeling After Myocardial Infarction Hypertension, April 1, 2005; 45(4): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals. A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research Arterioscler. Thromb. Vasc. Biol., March 1, 2005; 25(3): e22 - e33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Bernstein, H. D. Xiao, J. W. Adams, K. Frenzel, P. Li, X. Z. Shen, J. M. Cole, and S. Fuchs Establishing the Role of Angiotensin-Converting Enzyme in Renal Function and Blood Pressure Control through the Analysis of Genetically Modified Mice J. Am. Soc. Nephrol., March 1, 2005; 16(3): 583 - 591. [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Benjamim, C. Canetti, F. Q. Cunha, S. L. Kunkel, and M. Peters-Golden Opposing and Hierarchical Roles of Leukotrienes in Local Innate Immune versus Vascular Responses in a Model of Sepsis J. Immunol., February 1, 2005; 174(3): 1616 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lassila, K. Jandeleit-Dahm, K. K. Seah, C. M. Smith, A. C. Calkin, T. J. Allen, and M. E. Cooper Imatinib Attenuates Diabetic Nephropathy in Apolipoprotein E-Knockout Mice J. Am. Soc. Nephrol., February 1, 2005; 16(2): 363 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Kuster, E. Kotlyar, M. K. Rude, D. A. Siwik, R. Liao, W. S. Colucci, and F. Sam Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress and Inflammation in Mice With Chronic Pressure Overload Circulation, February 1, 2005; 111(4): 420 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals: A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research Hypertension, February 1, 2005; 45(2): 299 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. I. Caron, L. R. James, G. Lee, H.-S. Kim, and O. Smithies Lifelong genetic minipumps Physiol Genomics, January 20, 2005; 20(2): 203 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Copeland, H. S. Warren, S. F. Lowry, S. E. Calvano, D. Remick, and the Inflammation and the Host Response to Injury I Acute Inflammatory Response to Endotoxin in Mice and Humans Clin. Vaccine Immunol., January 1, 2005; 12(1): 60 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takahashi, M. L. S. S. Lopez, J. E. Cowhig Jr., M. A. Taylor, T. Hatada, E. Riggs, G. Lee, R. A. Gomez, H.-S. Kim, and O. Smithies Ren1c Homozygous Null Mice Are Hypotensive and Polyuric, but Heterozygotes Are Indistinguishable from Wild-Type J. Am. Soc. Nephrol., January 1, 2005; 16(1): 125 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Benigni, D. Corna, C. Zoja, L. Longaretti, E. Gagliardini, N. Perico, T. M. Coffman, and G. Remuzzi Targeted Deletion of Angiotensin II Type 1A Receptor Does not Protect Mice from Progressive Nephropathy of Overload Proteinuria J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2666 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Pederson, H. Chen, J. M. Schroeder, W. Shou, A. A. DePaoli-Roach, and P. J. Roach Abnormal Cardiac Development in the Absence of Heart Glycogen Mol. Cell. Biol., August 15, 2004; 24(16): 7179 - 7187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Le, M. I. Oliverio, H.-S. Kim, H. Salzler, R. C. Dash, D. N. Howell, O. Smithies, S. Bronson, and T. M. Coffman A {gamma}GT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice Physiol Genomics, August 11, 2004; 18(3): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lassila, K. K. Seah, T. J. Allen, V. Thallas, M. C. Thomas, R. Candido, W. C. Burns, J. M. Forbes, A. C. Calkin, M. E. Cooper, et al. Accelerated Nephropathy in Diabetic Apolipoprotein E-Knockout Mouse: Role of Advanced Glycation End Products J. Am. Soc. Nephrol., August 1, 2004; 15(8): 2125 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Deschepper, J. L. Olson, M. Otis, and N. Gallo-Payet Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains J Appl Physiol, July 1, 2004; 97(1): 369 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Forbes, L. T. L. Yee, V. Thallas, M. Lassila, R. Candido, K. A. Jandeleit-Dahm, M. C. Thomas, W. C. Burns, E. K. Deemer, S. R. Thorpe, et al. Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis Diabetes, July 1, 2004; 53(7): 1813 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Whitesall, J. B. Hoff, A. P. Vollmer, and L. G. D'Alecy Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2408 - H2415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lassila, T. J. Allen, Z. Cao, V. Thallas, K. A. Jandeleit-Dahm, R. Candido, and M. E. Cooper Imatinib Attenuates Diabetes-Associated Atherosclerosis Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 935 - 942. [Abstract] [Full Text]
|
|
|
|
|
|
S. Fuchs, H. D. Xiao, J. M. Cole, J. W. Adams, K. Frenzel, A. Michaud, H. Zhao, G. Keshelava, M. R. Capecchi, P. Corvol, et al. Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice J. Biol. Chem., April 16, 2004; 279(16): 15946 - 15953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. I. Caron, L. R. James, H.-S. Kim, J. Knowles, R. Uhlir, L. Mao, J. R. Hagaman, W. Cascio, H. Rockman, and O. Smithies Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene PNAS, March 2, 2004; 101(9): 3106 - 3111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Paul, K. W.S. Ko, L. Li, V. Yechoor, M. A. McCrory, A. J. Szalai, and L. Chan C-Reactive Protein Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice Circulation, February 10, 2004; 109(5): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Le, A. B. Fogo, H. R. Salzler, T. Vinogradova, M. I. Oliverio, D. A. Marchuk, and T. M. Coffman Modifier Locus on Mouse Chromosome 3 for Renal Vascular Pathology in AT1A Receptor-Deficiency Hypertension, February 1, 2004; 43(2): 445 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Moreno-Lopez, C. Romero-Grimaldi, J. A. Noval, M. Murillo-Carretero, E. R. Matarredona, and C. Estrada Nitric Oxide Is a Physiological Inhibitor of Neurogenesis in the Adult Mouse Subventricular Zone and Olfactory Bulb J. Neurosci., January 7, 2004; 24(1): 85 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dayoub, V. Achan, S. Adimoolam, J. Jacobi, M. C. Stuehlinger, B.-y. Wang, P. S. Tsao, M. Kimoto, P. Vallance, A. J. Patterson, et al. Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological Evidence Circulation, December 16, 2003; 108(24): 3042 - 3047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zahabi, S. Picard, N. Fortin, T. L. Reudelhuber, and C. F. Deschepper Expression of Constitutively Active Guanylate Cyclase in Cardiomyocytes Inhibits the Hypertrophic Effects of Isoproterenol and Aortic Constriction on Mouse Hearts J. Biol. Chem., November 28, 2003; 278(48): 47694 - 47699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. L. Woo and I. Kurtz Mapping blood pressure loci in (A/J x B6)F2 mice Physiol Genomics, November 11, 2003; 15(3): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kazama, G. Wang, K. Frys, J. Anrather, and C. Iadecola Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1890 - H1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bro, J. F. Bentzon, E. Falk, C. B. Andersen, K. Olgaard, and L. B. Nielsen Chronic Renal Failure Accelerates Atherogenesis in Apolipoprotein E-Deficient Mice J. Am. Soc. Nephrol., October 1, 2003; 14(10): 2466 - 2474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Le, H.-S. Kim, A. M. Allen, R. F. Spurney, O. Smithies, and T. M. Coffman Physiological Impact of Increased Expression of the AT1 Angiotensin Receptor Hypertension, October 1, 2003; 42(4): 507 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Taylor, A. D. Bonev, T. P. Gross, D. M. Eckman, J. E. Brayden, C. T. Bond, J. P. Adelman, and M. T. Nelson Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure Circ. Res., July 25, 2003; 93(2): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Hampton, A. Shimamoto, C. L. Rothnie, J. Griscavage-Ennis, A. Chong, D. J. Dix, E. D. Verrier, and T. H. Pohlman HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H866 - H874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takahashi, J. R. Hagaman, H.-S. Kim, and O. Smithies Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin System Endocrinology, June 1, 2003; 144(6): 2184 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Alexander, J. W. Knowles, T. Nishikimi, and N. Maeda Increased Atherosclerosis and Smooth Muscle Cell Hypertrophy in Natriuretic Peptide Receptor A-/-Apolipoprotein E-/- Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2003; 23(6): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Kessler, P. deS. Senanayake, T. S. Scheidemantel, J. B. Gomos, T. M. Rowe, and G. C. Sen Maintenance of Normal Blood Pressure and Renal Functions Are Independent Effects of Angiotensin-converting Enzyme J. Biol. Chem., May 30, 2003; 278(23): 21105 - 21112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kramer and L. B. Kinter Evaluation and applications of radiotelemetry in small laboratory animals Physiol Genomics, May 13, 2003; 13(3): 197 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Svenson, M. A. Bogue, and L. L. Peters Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains J Appl Physiol, April 1, 2003; 94(4): 1650 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gross and F. C. Luft Exercising Restraint in Measuring Blood Pressure in Conscious Mice Hypertension, April 1, 2003; 41(4): 879 - 881. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cole, N. Khokhlova, R. L. Sutliff, J. W. Adams, K. M. Disher, H. Zhao, M. R. Capecchi, P. Corvol, and K. E. Bernstein Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II Hypertension, February 1, 2003; 41(2): 313 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lochard, D. W. Silversides, J. P. van Kats, C. Mercure, and T. L. Reudelhuber Brain-specific Restoration of Angiotensin II Corrects Renal Defects Seen in Angiotensinogen-deficient Mice J. Biol. Chem., January 17, 2003; 278(4): 2184 - 2189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Meyer, M. Flagella, R. L. Sutliff, J. N. Lorenz, M. L. Nieman, C. S. Weber, R. J. Paul, and G. E. Shull Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl- cotransporter Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1846 - H1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Didion, M. J. Ryan, G. L. Baumbach, C. D. Sigmund, and F. M. Faraci Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1569 - H1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Landmesser, H. Cai, S. Dikalov, L. McCann, J. Hwang, H. Jo, S. M. Holland, and D. G. Harrison Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II Hypertension, October 1, 2002; 40(4): 511 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Mangrum, R. A. Gomez, and V. F. Norwood Effects of AT1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake Am J Physiol Renal Physiol, September 1, 2002; 283(3): F447 - F453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sugiyama, G. A. Churchill, R. Li, L. J. M. Libby, T. Carver, K.-I. Yagami, S. W. M. John, and B. Paigen QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice Physiol Genomics, July 12, 2002; 10(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Candido, K. A. Jandeleit-Dahm, Z. Cao, S. P. Nesteroff;, W. C. Burns, S. M. Twigg, R. J. Dilley, M. E. Cooper, and T. J. Allen Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice Circulation, July 9, 2002; 106(2): 246 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. I. Caron, L. R. James, H.-S. Kim, S. G. Morham, M. L. S. S. Lopez, R. A. Gomez, T. L. Reudelhuber, and O. Smithies A genetically clamped renin transgene for the induction of hypertension PNAS, June 11, 2002; 99(12): 8248 - 8252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. A. Janssen and J. F. M. Smits Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Lorenz A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1565 - R1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takahashi, H. L. Brooks, J. B. Wade, W. Liu, Y. Kondo, S. Ito, M. A. Knepper, and O. Smithies Posttranscriptional Compensation for Heterozygous Disruption of the Kidney-Specific NaK2Cl Cotransporter Gene J. Am. Soc. Nephrol., March 1, 2002; 13(3): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. H. Wong, S. Kulandavelu, K. J. Whiteley, D. Qu, B. L. Langille, and S. L. Adamson Maternal cardiovascular changes during pregnancy and postpartum in mice Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H918 - H925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W Manning, L. A Cassis, J. Huang, S. J Szilvassy, and A. Daugherty Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease Vascular Medicine, February 1, 2002; 7(1): 45 - 54. [Abstract] [PDF]
|
|