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(Hypertension. 1995;26:44-47.)
© 1995 American Heart Association, Inc.

Articles

Influence of Angiotensin II Type 1 Receptor Polymorphism on Aortic Stiffness in Never-Treated Hypertensive Patients

Athanase Benetos; Jirar Topouchian; Sylvain Ricard; Sylvie Gautier; Alain Bonnardeaux; Roland Asmar; Odile Poirier; Florent Soubrier; Michel Safar; François Cambien

From INSERM U337, Broussais Hospital (A. Benetos, J.T., S.G., R.A., M.S.), INSERM SC7 (S.R., O.P., F.C.), and INSERM U36, College de France (A. Bonnardeaux, F.S.), Paris, France.

Abstract Several clinical and experimental studies have suggested a significant role of angiotensin II in the development of alterations of small and large arteries. The present study was designed to assess the contribution of polymorphism (corresponding to an A¹¹⁶⁶C transversion) of the angiotensin II type 1 receptor (AT₁) gene to aortic stiffness. One hundred thirty-four never-treated hypertensive patients were included in the study. Aortic distensibility was evaluated by measuring carotid-femoral pulse wave velocity. Age, systolic and diastolic pressure, and metabolic parameters were similar in the three genotypes. Pulse wave velocity was 11.4±2.5 m/s in AT₁ AA homozygotes, 12.5±3.2 m/s in AC heterozygotes, and 14.7±4.0 m/s in CC homozygotes (P=.003, P<.001 after adjustment for age, blood pressure, and body mass index). Moreover, an interaction was found between AT₁ genotype and the ratio of total to high-density lipoprotein cholesterol in terms of the development of aortic stiffness. Thus, a positive correlation was observed between the ratio of total to high-density lipoprotein cholesterol and pulse wave velocity in AC and CC (r=.42, P<.001) but not AA patients. These results suggest that the AT₁ gene is involved in the development of aortic stiffness in hypertensive patients and could modulate the effects of lipids on large arteries.

Key Words: renin-angiotensin system • polymorphism (genetics) • receptors, angiotensin

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