(Hypertension. 1995;26:55-59.)
© 1995 American Heart Association, Inc.
Articles |
Circadian Profile of Systemic Hemodynamics
From the Department of Medicine and Biomedical Instrumentation–TNO (K.H.W.) Academic Medical Centre, Amsterdam, Netherlands.
Correspondence to D.P. Veerman, MD, PhD, Room B2-222, Department of Internal Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Abstract We determined the continuous 24-hour profile of mean arterial pressure, heart rate, stroke volume, cardiac output, and total peripheral resistance in eight healthy ambulatory volunteers. Beat-to-beat intra-arterial blood pressure was recorded with the Oxford system; subjects were ambulant during daytime and slept at night. Beat-to-beat stroke volume was determined by the pulse contour method from the arterial pulse wave. During the nighttime, compared with the daytime average, there was a decrease in blood pressure (9 mm Hg), heart rate (18 beats per minute), and cardiac output (29%); stroke volume showed a small decrease (7%), and total peripheral resistance increased unexpectedly by 22%. When subjects arose in the morning a steep increase in cardiac output and decrease in total peripheral resistance were found. Comparable changes were seen during a period of supine resting in the afternoon, whereas physical exercise caused opposite changes in hemodynamics. This pattern was observed in all subjects. We conclude that the circadian pattern of cardiac output and total peripheral resistance originates from the day-night pattern in physical activity: during the nighttime, blood flow to the skeletal muscles is decreased through local autoregulation, which increases total peripheral resistance and decreases cardiac output compared with the daytime.
Key Words: circadian rhythm • hemodynamics • blood pressure • heart rate
This article has been cited by other articles:
 |
|
 |
|
  N. van Dijk, M. C. Boer, T. De Santo, N. Grovale, A. J.J. Aerts, L. Boersma, and W. Wieling Daily, weekly, monthly, and seasonal patterns in the occurrence of vasovagal syncope in an older population Europace, September 1, 2007; 9(9): 823 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Sayk, C. Becker, C. Teckentrup, H.-L. Fehm, J. Struck, J. P. Wellhoener, and C. Dodt To Dip or Not to Dip: On the Physiology of Blood Pressure Decrease During Nocturnal Sleep in Healthy Humans Hypertension, May 1, 2007; 49(5): 1070 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Durgan, N. A. Trexler, O. Egbejimi, T. A. McElfresh, H. Y. Suk, L. E. Petterson, C. A. Shaw, P. E. Hardin, M. S. Bray, M. P. Chandler, et al. The Circadian Clock within the Cardiomyocyte Is Essential for Responsiveness of the Heart to Fatty Acids J. Biol. Chem., August 25, 2006; 281(34): 24254 - 24269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Young The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H1 - H16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kawano, T. Motoyama, H. Yasue, N. Hirai, H. M. Waly, K. Kugiyama, and H. Ogawa Endothelial function fluctuates with diurnal variation in the frequency of ischemic episodes in patients with variant angina J. Am. Coll. Cardiol., July 17, 2002; 40(2): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yang, E. Scalbert, P. Delagrange, P. M. Vanhoutte, and S. T. O'Rourke Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H76 - H82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Deguchi and C. J Mathias Continuous haemodynamic monitoring in an unusual case of swallow induced syncope J. Neurol. Neurosurg. Psychiatry, August 1, 1999; 67(2): 220 - 222. [Abstract] [Full Text] [PDF]
|
|