(Hypertension. 1995;26:221-229.)
© 1995 American Heart Association, Inc.
Articles |
Kallikreins and Kinins
Some Unanswered Questions About System Characteristics and Roles in Human Disease
From the Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston.
Correspondence to Harry S. Margolius, MD, PhD, Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425-2251. E-mail harry_margolius.pharmacology@smtpgw.musc.edu.
Abstract Kinins can affect many aspects of cellular function, but their roles in human homeostatic mechanisms and disease are just beginning to be understood. In this brief review, some of the interesting new observations about kallikrein-kinin system characteristics, roles in cell behavior, and aberrancy in diseases of relevance to readers interested in hypertension will be discussed. Along the way, questions raised by these observations will be posed. They show that we still have much to learn about the contributions of kinins to human cardiovascular diseases but now have in addition both a strong rationale for asking them and the tools to make them operational.
Key Words: kallikrein-kinin system • kininogens • bradykinin
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