(Hypertension. 1995;26:452-459.)
© 1995 American Heart Association, Inc.
Articles |
Blood Pressure in Genetically Hypertensive Rats
Influence of the Y Chromosome
From the Departments of Medicine and Therapeutics (A.O.D., A.W.K., J.L.R., A.F.D.) and Surgery (B.C.J.), and the Laboratory of Genetics IBLS (R.G.S.), The University of Glasgow (Scotland); and Department of Genetics, Case Western Reserve University, Cleveland, Ohio (N.S.).
Correspondence to Dr Anna F. Dominiczak, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK. E-mail gona41@udcf.gla.ac.uk.
Abstract We used a cross between the stroke-prone spontaneously hypertensive rat (SHRSP) strain and the Wistar-Kyoto (WKY) normotensive strain to elucidate the genetic basis of hypertension. Previous studies have reported conflicting evidence for the contribution of the Y chromosome to hypertension in these models. To investigate further the role of the Y chromosome in hypertension, we performed two large reciprocal crosses: one with the SHRSP as a male progenitor of the cross, yielding 60 F2 rats, and another with the WKY as a male progenitor, yielding 83 F2 rats. The resulting F2 hybrids were phenotyped with the use of a radiotelemetry system (Data Sciences) for measurement of systolic, diastolic, and mean arterial pressures as well as heart rate and motor activity continuously for 96 hours at baseline and after 1% NaCl was added to the rats' drinking water for 12 days. Male F2 hybrids with the SHRSP grandfather had significantly higher average systolic, diastolic, and mean arterial pressures at baseline compared with male F2 hybrids with the WKY grandfather (188.7±18.1 versus 168.9±11.5, 130.3±14 versus 115.7±7.3, and 159.1±15.8 versus 141.5±9.4 mm Hg, respectively). These differences were also observed after salt loading (197.9±22.1 versus 176.8±11.7, 136.5±17.3 versus 120.7±7.6, and 166.7±19.5 versus 148±9.7 mm Hg, respectively; P<.0001 for each comparison). These results suggest that the SHRSP Y chromosome contains a locus or loci that contribute to hypertension in SHRSP/WKY F2 hybrids.
Key Words: hypertension, genetic • rats, inbred strains • Y chromosome • telemetry
This article has been cited by other articles:
 |
|
 |
|
  C. McCabe, L. Gallagher, W. Gsell, D. Graham, A. F. Dominiczak, and I. M. Macrae Differences in the Evolution of the Ischemic Penumbra in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats Stroke, December 1, 2009; 40(12): 3864 - 3868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Graham, N. N. Huynh, C. A. Hamilton, E. Beattie, R. A.J. Smith, H. M. Cocheme, M. P. Murphy, and A. F. Dominiczak Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy Hypertension, August 1, 2009; 54(2): 322 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Masson, S. A. Nicklin, M. A. Craig, M. McBride, K. Gilday, P. Gregorevic, J. M. Allen, J. S. Chamberlain, G. Smith, D. Graham, et al. Onset of Experimental Severe Cardiac Fibrosis Is Mediated by Overexpression of Angiotensin-Converting Enzyme 2 Hypertension, April 1, 2009; 53(4): 694 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Turner, J. Farkas, J. Dunmire, D. Ely, and A. Milsted Which Sry Locus Is the Hypertensive Y Chromosome Locus? Hypertension, February 1, 2009; 53(2): 430 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Graham, M. W. McBride, M. Gaasenbeek, K. Gilday, E. Beattie, W. H. Miller, J. D. McClure, J. M. Polke, A. Montezano, R. M. Touyz, et al. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat: Congenic Analysis Hypertension, December 1, 2007; 50(6): 1134 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ibrahim, A. McGee, D. Graham, J. C. McGrath, and A. F. Dominiczak Sex-specific differences in cerebral arterial myogenic tone in hypertensive and normotensive rats Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1081 - H1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. McBride, M. J. Brosnan, J. Mathers, L. I. McLellan, W. H. Miller, D. Graham, N. Hanlon, C. A. Hamilton, J. M. Polke, W. K. Lee, et al. Reduction of Gstm1 Expression in the Stroke-Prone Spontaneously Hypertension Rat Contributes to Increased Oxidative Stress Hypertension, April 1, 2005; 45(4): 786 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. McBride, F. J. Charchar, D. Graham, W. H. Miller, P. Strahorn, F. J. Carr, and A. F. Dominiczak Functional genomics in rodent models of hypertension J. Physiol., January 1, 2004; 554(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. McBride, F. J. Carr, D. Graham, N. H. Anderson, J. S. Clark, W. K. Lee, F. J. Charchar, M. J. Brosnan, and A. F. Dominiczak Microarray Analysis of Rat Chromosome 2 Congenic Strains Hypertension, March 1, 2003; 41(3): 847 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yagil, N. Hubner, R. Kreutz, D. Ganten, and Y. Yagil Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension Physiol Genomics, January 15, 2003; 12(2): 85 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Charchar, M. Tomaszewski, S. Padmanabhan, B. Lacka, M. N. Upton, G. C. Inglis, N. H. Anderson, A. McConnachie, E. Zukowska-Szczechowska, W. Grzeszczak, et al. The Y Chromosome Effect on Blood Pressure in Two European Populations Hypertension, February 1, 2002; 39(2): 353 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Marks, H. V.O. Carswell, E. E. Peters, D. I. Graham, J. Patterson, A. F. Dominiczak, and I. M. Macrae Characterization of the Microglial Response to Cerebral Ischemia in the Stroke-Prone Spontaneously Hypertensive Rat Hypertension, July 1, 2001; 38(1): 116 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kren, N. Qi, D. Krenova, V. Zidek, M. Sladka, M. Jachymova, B. Mikova, K. Horky, A. Bonne, H. A. Van Lith, et al. Y-Chromosome Transfer Induces Changes in Blood Pressure and Blood Lipids in SHR Hypertension, April 1, 2001; 37(4): 1147 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Negrin, M. W. McBride, H. V. O. Carswell, D. Graham, F. J. Carr, J. S. Clark, B. Jeffs, N. H. Anderson, I. M. Macrae, and A. F. Dominiczak Reciprocal Consomic Strains to Evaluate Y Chromosome Effects Hypertension, February 1, 2001; 37(2): 391 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Hamilton, M. J. Brosnan, M. McIntyre, D. Graham, and A. F. Dominiczak Superoxide Excess in Hypertension and Aging : A Common Cause of Endothelial Dysfunction Hypertension, February 1, 2001; 37(2): 529 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ellis, M. Stebbing, and S. B. Harrap Association of the Human Y Chromosome With High Blood Pressure in the General Population Hypertension, November 1, 2000; 36(5): 731 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.Y. Alexander, M.J. Brosnan, C. A. Hamilton, J. P. Fennell, E. C. Beattie, E. Jardine, D. D. Heistad, and A. F. Dominiczak Gene transfer of endothelial nitric oxide synthase but not Cu/Zn superoxide dismutase restores nitric oxide availability in the SHRSP Cardiovasc Res, August 18, 2000; 47(3): 609 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Devlin, J. S. Clark, J. L. Reid, and A. F. Dominiczak DNA Synthesis and Apoptosis in Smooth Muscle Cells From a Model of Genetic Hypertension Hypertension, July 1, 2000; 36(1): 110 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gutkowska, M. Jankowski, S. Mukaddam-Daher, and S. M. McCann Corticotropin-releasing hormone causes antidiuresis and antinatriuresis by stimulating vasopressin and inhibiting atrial natriuretic peptide release in male rats PNAS, January 4, 2000; 97(1): 483 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Rapp Genetic Analysis of Inherited Hypertension in the Rat Physiol Rev, January 1, 2000; 80(1): 135 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jeffs, C. D. Negrin, D. Graham, J. S. Clark, N. H. Anderson, D. Gauguier, and A. F. Dominiczak Applicability of a "Speed" Congenic Strategy to Dissect Blood Pressure Quantitative Trait Loci on Rat Chromosome 2 Hypertension, January 1, 2000; 35(1): 179 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.Y. Alexander, M.J. Brosnan, C. A Hamilton, P. Downie, A. M Devlin, F. Dowell, W. Martin, H. M Prentice, T. O'Brien, and A. F Dominiczak Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model Cardiovasc Res, August 15, 1999; 43(3): 798 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kerr, M. J. Brosnan, M. McIntyre, J. L. Reid, A. F. Dominiczak, and C. A. Hamilton Superoxide Anion Production Is Increased in a Model of Genetic Hypertension : Role of the Endothelium Hypertension, June 1, 1999; 33(6): 1353 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. O. Carswell, N. H. Anderson, J. S. Clark, D. Graham, B. Jeffs, A. F. Dominiczak, and I. M. Macrae Genetic and Gender Influences on Sensitivity to Focal Cerebral Ischemia in the Stroke-Prone Spontaneously Hypertensive Rat Hypertension, February 1, 1999; 33(2): 681 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Anderson, A. M. Devlin, D. Graham, J. J. Morton, C. A. Hamilton, J. L. Reid, N. J. Schork, and A. F. Dominiczak Telemetry for Cardiovascular Monitoring in a Pharmacological Study : New Approaches to Data Analysis Hypertension, January 1, 1999; 33(1): 248 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Brosnan, J. S. Clark, B. Jeffs, C. D. Negrin, P. Van Vooren, S. M. Arribas, H. Carswell, T. J. Aitman, C. Szpirer, I. M. Macrae, et al. Genes Encoding Atrial and Brain Natriuretic Peptides as Candidates for Sensitivity to Brain Ischemia in Stroke-Prone Hypertensive Rats Hypertension, January 1, 1999; 33(1): 290 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gratton, A. Sauter, M. Rudin, K. R. Lees, J. McColl, J. L. Reid, A. F. Dominiczak, I. M. Macrae, and D. F. Bohr Susceptibility to Cerebral Infarction in the Stroke-Prone Spontaneously Hypertensive Rat Is Inherited as a Dominant Trait • Editorial Comment Stroke, March 1, 1998; 29(3): 690 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ely, A. Caplea, G. Dunphy, H. Daneshvar, M. Turner, A. Milsted, and M. Takiyyuddin Spontaneously Hypertensive Rat Y Chromosome Increases Indexes of Sympathetic Nervous System Activity Hypertension, February 1, 1997; 29(2): 613 - 618. [Abstract] [Full Text]
|
|
|
|
|
|
R. Kreutz, P. Stock, B. Struk, and K. Lindpaintner The Y Chromosome: Epistatic and Ecogenetic Interactions in Genetic Hypertension Hypertension, November 1, 1996; 28(5): 895 - 897. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Clark, B. Jeffs, A. O. Davidson, W. K. Lee, N. H. Anderson, M.-T. Bihoreau, M. J. Brosnan, A. M. Devlin, A. W. Kelman, K. Lindpaintner, et al. Quantitative Trait Loci in Genetically Hypertensive Rats: Possible Sex Specificity Hypertension, November 1, 1996; 28(5): 898 - 906. [Abstract] [Full Text]
|
|
|
|
|
|
A. F. Dominiczak, A. M. Devlin, W. K. Lee, N. H. Anderson, D. F. Bohr, and J. L. Reid Vascular Smooth Muscle Polyploidy and Cardiac Hypertrophy in Genetic Hypertension Hypertension, March 1, 1996; 27(3): 752 - 759. [Abstract] [Full Text]
|
|