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Hypertension. 1995;26:503-508

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(Hypertension. 1995;26:503-508.)
© 1995 American Heart Association, Inc.


Articles

Noninvasive Pulse Wave Analysis for the Early Detection of Vascular Disease

Jay N. Cohn; Stanley Finkelstein; Gary McVeigh; Dennis Morgan; Lisa LeMay; Jennifer Robinson; James Mock

From the Cardiovascular Division (J.N.C., D.M., L.L., J.R., J.M.) and the General and Preventive Medicine Division (G.M.), Department of Medicine, and the Division of Health Computer Sciences, Department of Laboratory Medicine and Pathology (S.F.), University of Minnesota Medical School, Minneapolis.

Abstract A noninvasive technique has been developed and validated for calculating capacitive and oscillatory systemic arterial compliance with the use of pulse wave analysis and a modified Windkessel model. Application of the technique to subjects with hypertension, postmenopausal women with symptomatic coronary artery disease, and appropriate control subjects has confirmed a reduction of oscillatory compliance in the disease states and an increase in capacitive and oscillatory compliances in response to vasodilator drugs. This method should be useful in screening subjects for early evidence of vascular disease and in monitoring the response to therapy.


Key Words: arterial compliance • cardiac output • vasodilation drugs • atherosclerosis • hypertension




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