(Hypertension. 1995;26:1024-1029.)
© 1995 American Heart Association, Inc.
Articles |
Role of Nitric Oxide in Modulating the Vasoconstrictor Actions of Angiotensin II in Preglomerular and Postglomerular Vessels in Dogs
From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson.
Abstract The purpose of this study was to determine the role
of nitric oxide in modulating the vasoconstrictor effect of
angiotensin II (Ang II) on renal segmental resistances in
the dog. To achieve this objective we examined the effect of intrarenal
infusions of Ang II on preglomerular and
postglomerular resistances in the presence and absence
of intrarenal nitric oxide synthesis inhibition established by an
intrarenal infusion of
NG-nitro-L-arginine-methyl
ester at 5 µg/kg per minute in dogs. The whole-kidney
stop-flow technique was used. Renal artery pressure was
servo-controlled at 78±2 mm Hg throughout the study. Intrarenal
infusion of Ang II alone at 0.5 and 2.0 ng/kg per minute increased
renal vascular resistance (
0.064±0.011 and 0.171±0.030
mm Hg/mL per minute, respectively) and decreased renal blood flow
(21±4 and 45±9 mL/min). Associated with these changes,
glomerular hydrostatic pressure and
preglomerular resistance increased slightly
(1.1±0.9 and 1.6±1.8 mm Hg; 0.008±0.005 and
0.030±0.010 mm Hg/mL per minute, respectively), and
postglomerular resistance increased markedly
(0.046±0.011 and 0.116±0.026 mm Hg/mL per minute). When dogs
were pretreated with an intrarenal infusion of the nitric oxide
synthesis blocker, Ang II at 0.5 and 2.0 ng/kg per minute increased
renal vascular resistance (0.271±0.058 and 1.088±0.242
mm Hg/mL per minute) and decreased renal blood flow (28±5 and
62±9 mL/min). However, in sharp contrast to vehicle pretreatment,
Ang II decreased glomerular hydrostatic pressure
(3.4±1.5 and 9.9±2.0 mm Hg), increased
postglomerular resistance (0.122±0.029 and
0.439±0.133 mm Hg/mL per minute), and increased
preglomerular resistance (0.109±0.031 and
0.487±0.099 mm Hg/mL per minute) in dogs pretreated with the
nitric oxide synthesis inhibitor. In summary, these data
indicate that during vehicle treatment Ang II infusion in the
stop-flow kidney had a predominant effect on
postglomerular resistance. However, when nitric oxide
synthesis was blocked, Ang II had a profound effect on
preglomerular resistance. These findings suggest that
nitric oxide may play an important role in protecting mainly
preglomerular vessels and to a lesser extent
postglomerular vessels from Ang II–induced renal
vasoconstriction in dogs.
Key Words: nitric oxide • angiotensin II • dogs • vasoconstriction • kidney
This article has been cited by other articles:
 |
|
 |
|
  F. Salazar, V. Reverte, F. Saez, A. Loria, M. T. Llinas, and F. J. Salazar Age- and Sodium-Sensitive Hypertension and Sex-Dependent Renal Changes in Rats With a Reduced Nephron Number Hypertension, April 1, 2008; 51(4): 1184 - 1189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Toda, K. Ayajiki, and T. Okamura Interaction of Endothelial Nitric Oxide and Angiotensin in the Circulation Pharmacol. Rev., March 1, 2007; 59(1): 54 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Cowley Jr., T. Mori, D. Mattson, and A.-P. Zou Role of renal NO production in the regulation of medullary blood flow Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1355 - R1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Reckelhoff and J. C. Romero Role of oxidative stress in angiotensin-induced hypertension Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R893 - R912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lopez, M. T. Llinas, F. Roig, and F. J. Salazar Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R488 - R493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alonso-Galicia, K. G. Maier, A. S. Greene, A. W. Cowley Jr., and R. J. Roman Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R60 - R68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moreno, A. Lopez, M. T. Llinas, F. Rodriguez, A. Lopez-Farre, E. Nava, and F. J. Salazar Changes in NOS activity and protein expression during acute and prolonged ANG II administration Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R31 - R37. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Uhlenius, O. Vuolteenaho, and I. Tikkanen Renin-angiotensin blockade improves renal cGMP production via non-AT2-receptor mediated mechanisms in hypertension-induced by chronic NOS inhibition in rat Journal of Renin-Angiotensin-Aldosterone System, December 1, 2001; 2(4): 233 - 239. [Abstract] [PDF]
|
|
|
|
|
|
M. J. Solhaug, U. Kullaprawithaya, X. Q. Dong, and K.-W. Dong Expression of endothelial nitric oxide synthase in the postnatal developing porcine kidney Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1269 - R1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cases, J. Haas, J. C. Burnett, and J. C. Romero Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R143 - R148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Solhaug, X. Q. Dong, R. D. Adelman, and K.-W. Dong Ontogeny of neuronal nitric oxide synthase, NOS I, in the developing porcine kidney Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1453 - R1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. McGiff and J. Quilley 20-HETE and the kidney: resolution of old problems and new beginnings Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R607 - R623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. MILLER Impact of Hyperglycemia on the Renin Angiotensin System in Early Human Type 1 Diabetes Mellitus J. Am. Soc. Nephrol., August 1, 1999; 10(8): 1778 - 1785. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Rudd, M. Trolliet, S. Hope, A. W. Scribner, G. Daumerie, G. Toolan, T. Cloutier, and J. Loscalzo Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H732 - H739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Braam Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1551 - R1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-L. Liu and I. H. Zucker Regulation of Sympathetic Nerve Activity in Heart Failure : A Role for Nitric Oxide and Angiotensin II Circ. Res., March 5, 1999; 84(4): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Liu, H. Murakami, and I. H. Zucker Angiotensin II–Nitric Oxide Interaction on Sympathetic Outflow in Conscious Rabbits Circ. Res., March 9, 1998; 82(4): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-P. Zou, F. Wu, and A. W. Cowley Jr Protective Effect of Angiotensin II-Induced Increase in Nitric Oxide in the Renal Medullary Circulation Hypertension, January 1, 1998; 31(1): 271 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Hennington, H. Zhang, M. T. Miller, J. P. Granger, and J. F. Reckelhoff Angiotensin II Stimulates Synthesis of Endothelial Nitric Oxide Synthase Hypertension, January 1, 1998; 31(1): 283 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Montanari, E. Tateo, E. Fasoli, D. Giberti, P. Perinotto, A. Novarini, and P. Dall'Aglio Angiotensin II Blockade Does Not Prevent Renal Effects of L-NAME in Sodium-Repleted Humans Hypertension, September 1, 1997; 30(3): 557 - 562. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Gironacci, P. S. Lorenzo, and E. Adler-Graschinsky Possible Participation of Nitric Oxide in the Increase of Norepinephrine Release Caused by Angiotensin Peptides in Rat Atria Hypertension, June 1, 1997; 29(6): 1344 - 1350. [Abstract] [Full Text]
|
|
|
|
|
|
J. Granger, C. Schnackenberg, J. Novak, B. Tucker, T. Miller, S. Morgan, and S. Kassab Role of Nitric Oxide in Modulating the Long-term Renal and Hypertensive Actions of Norepinephrine Hypertension, January 1, 1997; 29(1): 205 - 209. [Abstract] [Full Text] [PDF]
|
|