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(Hypertension. 1995;26:1100-1104.)
© 1995 American Heart Association, Inc.

Articles

Autonomic Dysfunction in Short-term Experimental Diabetes

C.Y. Maeda; T.G. Fernandes; H.B. Timm; M.C. Irigoyen

From the Laboratory of Cardiovascular Physiology, Department of Physiology, Biosciences Institute, University of Rio Grande do Sul, Brazil, and from PBIC Conselho Nacional de Desenvolvimento Científico e Tecnológico (C.Y.M., H.B.T.).

Correspondence to Maria Cláudia Irigoyen, MD, PhD, Department of Physiology, Biosciences Institute, University of Rio Grande do Sul, Brazil, Rua Sarmento Leite 500, Porto Alegre, Rio Grande do Sul 90050-170, Brazil.

Abstract Previous data showed that diabetes induced by streptozotocin for 5 days causes changes in arterial pressure control and baroreflex regulation of heart rate in male Wistar rats. The impairment of baroreflex may be related to autonomic neuropathy as described by several investigators. The aim of this study was to identify autonomic changes in short-term experimental diabetes in rats (induced for 5 days with streptozotocin 65 mg IP). Intra-arterial blood pressure signals were obtained from 6 control group and 7 diabetic group rats and processed in a data acquisition system (CODAS, 1 kHz). Both vagal and sympathetic function were assessed through intravenous injections of methylatropine and propranolol. Streptozotocin induced hyperglycemia (18.9±1.8 versus 5.8±0.2 mmol/L) and reductions in mean arterial pressure (102±2 versus 117±3 mm Hg) and resting heart rate (298±14 versus 332±2 beats per minute). Sodium and potassium levels were not different between groups. The intrinsic heart rate was reduced in the diabetic group (302±10 versus 398±6 beats per minute). This group also exhibited depressed vagal and sympathetic tone (50% and 22%, respectively), reduction of vagal effect (42%), and no change in sympathetic effect. In conclusion, early autonomic dysfunction in short-term streptozotocin-induced diabetes seems to be related to changes in arterial pressure and baroreflex control.

Key Words: streptozocin • diabetes mellitus, experimental • baroreflex • heart rate • sympathetic nervous system

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