(Hypertension. 1995;26:869-879.)
© 1995 American Heart Association, Inc.
Articles |
Diabetes Mellitus and Associated Hypertension, Vascular Disease, and Nephropathy
An Update
From Wayne State University (Detroit, Mich) and Miami (Fla) University Schools of Medicine and VA Medical Centers.
Correspondence to James R. Sowers, MD, Wayne State University School of Medicine, UHC-4H, 4201 St Antoine, Detroit, MI 48201.
Abstract Because considerable important information has been published since our previous review, this update concentrates on new findings with regard to cardiovascular and renal risk factors contributing to the striking morbidity and mortality of these coexisting diseases. For example, a large body of investigative data has recently emerged suggesting or delineating a pathogenic role for hyperglycemic-related glycosylation and oxidation of lipoproteins and vascular and renal tissues. Great strides have recently been made in the understanding of platelet, coagulation, lipoprotein, and endothelial abnormalities in the pathogenesis of cardiovascular and renal disease associated with diabetes mellitus and hypertension. Major progress has been made in clarifying the pathophysiology of glomerulosclerosis and other processes involved in the progression of diabetic nephropathy. Furthermore, accumulating data surveyed in this review address new and promising pharmacological interventions that specifically address these pathophysiological mechanisms.
Key Words: diabetes mellitus • cardiovascular disease • diabetic nephropathy
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