(Hypertension. 1996;27:102-107.)
© 1996 American Heart Association, Inc.
Articles |
Plasma Adrenomedullin Concentrations in Essential Hypertension
From the First Department of Internal Medicine, Osaka City (Japan) University Medical School.
Correspondence to Masakazu Kohno, MD, Division of Hypertension and Atherosclerosis, First Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan.
Abstract We designed the present study to assess any changes in plasma concentrations of the novel vasorelaxant peptide adrenomedullin in patients with essential hypertension. Plasma adrenomedullin concentrations were measured in 45 patients with untreated essential hypertension, 15 patients with borderline hypertension, and 30 normotensive control subjects. After 4 weeks of effective calcium channel blocker–based antihypertensive therapy, adrenomedullin concentrations were measured again. The concentrations were higher in hypertensive patients with increased serum creatinine levels or decreased glomerular filtration rates compared with borderline hypertensive patients and normotensive subjects, although values in normotensive and hypertensive individuals overlapped. Plasma adrenomedullin concentrations were positively correlated with serum creatinine levels and inversely correlated with glomerular filtration rates in the hypertensive patients, whereas adrenomedullin values were not correlated with blood pressure level, left ventricular mass index, or left ventricular ejection fraction. Despite blood pressure control with antihypertensive therapy, plasma adrenomedullin concentrations were not changed. Reversed-phase high-performance liquid chromatographic analysis showed that a major component of immunoreactive adrenomedullin in the plasma of normotensive subjects and hypertensive patients is human adrenomedullin-(1-52). These results indicate that plasma adrenomedullin concentrations are elevated in many hypertensive patients with renal dysfunction and its major component is human adrenomedullin-(1-52).
Key Words: adrenomedullin • hypertension, essential • renal function • chromatography
This article has been cited by other articles:
 |
|
 |
|
  A. Mak, B. M. Y. Cheung, C. C. Mok, R. Leung, and C. S. Lau Adrenomedullin--a potential disease activity marker and suppressor of nephritis activity in systemic lupus erythematosus Rheumatology, October 1, 2006; 45(10): 1266 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Dackor, K. Fritz-Six, W. P. Dunworth, C. L. Gibbons, O. Smithies, and K. M. Caron Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Mol. Cell. Biol., April 1, 2006; 26(7): 2511 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Ishikawa, K Hatakeyama, T Imamura, K Ito, S Hara, H Date, Y Shibata, Y Hikichi, Y Asada, and T Eto Increased adrenomedullin immunoreactivity and mRNA expression in coronary plaques obtained from patients with unstable angina Heart, October 1, 2004; 90(10): 1206 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Brain and A. D. Grant Vascular Actions of Calcitonin Gene-Related Peptide and Adrenomedullin Physiol Rev, July 1, 2004; 84(3): 903 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Champion, T. J. Bivalacqua, R. L. Pierce, W. A. Murphy, D. H. Coy, A. L. Hyman, and P. J. Kadowitz Responses to human CGRP, ADM, and PAMP in human thymic arteries Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R531 - R537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Maniu, D. M. Meyer, and M. M. Redfield Hemodynamic and Humoral Effects of Vasopeptidase Inhibition in Canine Hypertension Hypertension, October 1, 2002; 40(4): 528 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Letizia, S. Subioli, S. Cerci, C. Caliumi, C. Verrelli, E. Delfini, M. Celi, L. Scuro, and E. D'Erasmo High plasma adrenomedullin concentrations in patients with high-renin essential hypertension Journal of Renin-Angiotensin-Aldosterone System, June 1, 2002; 3(2): 126 - 129. [Abstract] [PDF]
|
|
|
|
 |
|
 S Kaufman, P Andrew, R Sultanian, and Y Deng Adrenomedullin increases fluid extravasation from the splenic circulation of the rat J. Physiol., July 15, 2001; 534(2): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jerat, D. W. Morrish, S. T. Davidge, and S. Kaufman Effect of Adrenomedullin on Placental Arteries in Normal and Preeclamptic Pregnancies Hypertension, February 1, 2001; 37(2): 227 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Terata, H. Miura, Y. Liu, F. Loberiza, and D. D. Gutterman Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K+ channels Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2620 - H2626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Troughton, L. K. Lewis, T. G. Yandle, A. M. Richards, and M. G. Nicholls Hemodynamic, Hormone, and Urinary Effects of Adrenomedullin Infusion in Essential Hypertension Hypertension, October 1, 2000; 36(4): 588 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Piquard, A. Charloux, B. Mettauer, E. Epailly, E. Lonsdorfer, S. Popescu, J. Lonsdorfer, and B. Geny Exercise-Induced Increase in Circulating Adrenomedullin Is Related to Mean Blood Pressure in Heart Transplant Recipients J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2828 - 2831. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. P. Hinson, S. Kapas, and D. M. Smith Adrenomedullin, a Multifunctional Regulatory Peptide Endocr. Rev., April 1, 2000; 21(2): 138 - 167. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. KOHNO, K. YASUNARI, M. MINAMI, H. KANO, K. MAEDA, A. K. MANDAL, K. INOKI, M. HANEDA, and J. YOSHIKAWA Regulation of Rat Mesangial Cell Migration by Platelet-Derived Growth Factor, Angiotensin II, and Adrenomedullin J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2495 - 2502. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Geny, G. Brandenberger, J. Lonsdorfer, N. Chakfe, P. Haberey, and F. Piquard Circulating adrenomedullin is increased after heart transplantation Cardiovasc Res, March 1, 1999; 41(3): 731 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mahata, S. K. Mahata, R. J. Parmer, and D. T. O'Connor Proadrenomedullin N-Terminal 20 Peptide : Minimal Active Region to Regulate Nicotinic Receptors Hypertension, November 1, 1998; 32(5): 907 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Di Iorio, E. Marinoni, C. Letizia, P. Alo, B. Villaccio, and E. V. Cosmi Adrenomedullin, a New Vasoactive Peptide, Is Increased in Preeclampsia Hypertension, October 1, 1998; 32(4): 758 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Iwasaki, S. Eguchi, M. Shichiri, F. Marumo, and Y. Hirata Adrenomedullin as a Novel Growth-Promoting Factor for Cultured Vascular Smooth Muscle Cells: Role of Tyrosine Kinase-Mediated Mitogen-Activated Protein Kinase Activation Endocrinology, August 1, 1998; 139(8): 3432 - 3441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kohno, K. Yokokawa, K. Yasunari, M. Minami, H. Kano, T. Hanehira, and J. Yoshikawa Induction by Lysophosphatidylcholine, a Major Phospholipid Component of Atherogenic Lipoproteins, of Human Coronary Artery Smooth Muscle Cell Migration Circulation, July 28, 1998; 98(4): 353 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Cameron and A. M. Fleming Novel Sites of Adrenomedullin Gene Expression in Mouse and Rat Tissues Endocrinology, May 1, 1998; 139(5): 2253 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Rademaker, C. J. Charles, L. K. Lewis, T. G. Yandle, G. J. S. Cooper, D. H. Coy, A. M. Richards, and M. G. Nicholls Beneficial Hemodynamic and Renal Effects of Adrenomedullin in an Ovine Model of Heart Failure Circulation, September 16, 1997; 96(6): 1983 - 1990. [Abstract] [Full Text]
|
|
|
|
|
|
T. Sumimoto, T. Nishikimi, M. Mukai, K. Matsuzaki, E. Murakami, S. Takishita, A. Miyata, H. Matsuo, and K. Kangawa Plasma Adrenomedullin Concentrations and Cardiac and Arterial Hypertrophy in Hypertension Hypertension, September 1, 1997; 30(3): 741 - 745. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kohno, K. Yokokawa, H. Kano, K. Yasunari, M. Minami, T. Hanehira, and J. Yoshikawa Adrenomedullin Is a Potent Inhibitor of Angiotensin II–Induced Migration of Human Coronary Artery Smooth Muscle Cells Hypertension, June 1, 1997; 29(6): 1309 - 1313. [Abstract] [Full Text]
|
|
|
|
|
|
P. G. Andreis, G. Neri, T. Prayer-Galetti, G. P. Rossi, G. Gottardo, L. K. Malendowicz, and G. G. Nussdorfer Effects of Adrenomedullin on the Human Adrenal Glands: An in Vitro Study J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1167 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Meeran, D. O'Shea, P. D. Upton, C. J. Small, M. A. Ghatei, P. H. Byfield, and S. R. Bloom Circulating Adrenomedullin Does Not Regulate Systemic Blood Pressure but Increases Plasma Prolactin after Intravenous Infusion in Humans: A Pharmacokinetic Study J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 95 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Lang, R. Paterno, F. M. Faraci, D. D. Heistad, and J. R. Kirsch Mechanisms of Adrenomedullin-Induced Dilatation of Cerebral Arterioles Stroke, January 1, 1997; 28(1): 181 - 185. [Abstract] [Full Text]
|
|
|
|
|
|
T. Shimosawa and T. Fujita Hypotensive Effect of a Newly Identified Peptide, Proadrenomedullin N-Terminal 20 Peptide Hypertension, September 1, 1996; 28(3): 325 - 329. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kohno, K. Yasunari, K. Yokokawa, T. Horio, M. Ikeda, H. Kano, M. Minami, T. Hanehira, and J. Yoshikawa Interaction of Adrenomedullin and Platelet-Derived Growth Factor on Rat Mesangial Cell Production of Endothelin Hypertension, March 1, 1996; 27(3): 663 - 667. [Abstract] [Full Text]
|
|