This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takeda, Y. Articles by Takeda, R. Search for Related Content PubMed PubMed Citation Articles by Takeda, Y. Articles by Takeda, R.

(Hypertension. 1996;27:197-201.)
© 1996 American Heart Association, Inc.

Articles

Endogenous Renal 11ß-Hydroxysteroid Dehydrogenase Inhibitory Factors in Patients With Low-Renin Essential Hypertension

Yoshiyu Takeda; Isamu Miyamori; Kazuhiro Iki; Satoru Inaba; Kenji Furukawa; Haruhiko Hatakeyama; Takashi Yoneda; Ryoyu Takeda

From the Second Department of Internal Medicine (Y.T., I.M., K.I., S.I., K.F., H.H., T.Y., R.T.) and Department of Health Sciences (Y.T.), School of Medicine, Kanazawa (Japan) University.

Correspondence to Yoshiyu Takeda, MD, Second Department of Internal Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920, Japan.

Abstract 11ß-Hydroxysteroid dehydrogenase (11ß-HSD) modulates the access of corticosteroids to their receptors and is important in blood pressure control. The excretion of renal 11ß-HSD (ie, NAD⁺-dependent isoform) is thought to protect renal mineralocorticoid receptors from cortisol. To examine whether endogenous renal 11ß-HSD inhibitory factor(s) may be involved in the pathophysiology of hypertension, we studied the urinary excretion of such inhibitors in 30 patients with low-renin essential hypertension and 20 normotensive control subjects. The effect of sodium restriction on the urinary excretion of the inhibitors was also evaluated in six normotensive control subjects. Urine was extracted with Sep-Pak cartridges and high-performance liquid chromatography. Endogenous renal 11ß-HSD inhibitors were measured by the inhibition of 11ß-HSD bioactivity in microsomes from the human kidney. The urinary excretion of the inhibitors was significantly increased in patients with low-renin essential hypertension (1280±88 nmol/d, mean±SEM) compared with normotensive control subjects (704±56 nmol/d) (P<.05). Ratios of urinary tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone did not differ significantly. Sodium restriction reduced the urinary excretion of the endogenous renal 11ß-HSD inhibitors but did not affect the ratio of urinary tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone. Endogenous renal 11ß-HSD inhibitory factors may contribute to the pathogenesis of low-renin essential hypertension by modulating the activity of 11ß-HSD. Sodium intake may directly or indirectly regulate the inhibitory factors.

Key Words: hydroxysteroid dehydrogenase • adrenal cortex hormones • renin • kidney

This article has been cited by other articles:

				B. Bocchi, S. Kenouch, M. Lamarre-Cliche, M. Muffat-Joly, M. H. Capron, J. Fiet, G. Morineau, M. Azizi, J. P. Bonvalet, and N. Farman Impaired 11-{beta} Hydroxysteroid Dehydrogenase Type 2 Activity in Sweat Gland Ducts in Human Essential Hypertension Hypertension, April 1, 2004; 43(4): 803 - 808. [Abstract] [Full Text] [PDF]

				J. A. Whitworth, G. J. Mangos, and J. J. Kelly Cushing, Cortisol, and Cardiovascular Disease Hypertension, November 1, 2000; 36(5): 912 - 916. [Abstract] [Full Text] [PDF]

				H. Hatakeyama, S. Inaba, and I. Miyamori 11ß-Hydroxysteroid Dehydrogenase in Cultured Human Vascular Cells : Possible Role in the Development of Hypertension Hypertension, May 1, 1999; 33(5): 1179 - 1184. [Abstract] [Full Text] [PDF]

				M. E Ullian The role of corticosteroids in the regulation of vascular tone Cardiovasc Res, January 1, 1999; 41(1): 55 - 64. [Full Text] [PDF]

				Y. Takeda, S. Inaba, K. Furukawa, and I. Miyamori Renal 11ß-Hydroxysteroid Dehydrogenase in Genetically Salt-Sensitive Hypertensive Rats Hypertension, December 1, 1998; 32(6): 1077 - 1082. [Abstract] [Full Text] [PDF]

				S. H.M. van Uum, A. R.M.M. Hermus, P. Smits, T. Thien, and J. W.M. Lenders The role of 11{beta}-hydroxysteroid dehydrogenase in the pathogenesis of hypertension Cardiovasc Res, April 1, 1998; 38(1): 16 - 24. [Abstract] [Full Text] [PDF]

				D. J. Morris, Y. H. Lo, W. R. Lichtfield, and G. H. Williams Impact of Dietary Na+ on Glycyrrhetinic Acid-Like Factors (Kidney 11{beta}-(HSD2)-GALFs) in Human Essential Hypertension Hypertension, January 1, 1998; 31(1): 469 - 472. [Abstract] [Full Text] [PDF]

				P. C. White, T. Mune, and A. K. Agarwal 11{beta}-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess Endocr. Rev., February 1, 1997; 18(1): 135 - 156. [Abstract] [Full Text]

				Y. H. Lo, M. F. Sheff, S. A. Latif, C. Ribeiro, H. Silver, A. S. Brem, and D. J. Morris Kidney 11{beta}-HSD2 Is Inhibited by Glycyrrhetinic Acid-Like Factors in Human Urine Hypertension, January 1, 1997; 29(1): 500 - 505. [Abstract] [Full Text] [PDF]