| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 1996;27:245-250.)
© 1996 American Heart Association, Inc.
Articles |
Effects of Amlodipine on Glomerular Filtration, Growth, and Injury in Experimental Hypertension
From the Department of Medicine, Brown University and Rhode Island Hospital, Providence (L.D.D., E.T.), and the Departments of Medicine (P.A.R.) and Pathology (J.C.H., H.F., R.I.L.), New York University Medical Center, New York.
Abstract The objective of this study was to determine whether the calcium antagonist amlodipine could slow the progression of chronic renal disease. We examined the effects of amlodipine on kidney structure and function in two experimental models of hypertension. In the first study, adult, male Munich Wistar rats underwent uninephrectomy and were given weekly injections of desoxycorticosterone and 1% saline for drinking. Rats ingested normal chow or chow containing amlodipine for 8 weeks. The drug reduced systemic blood pressure, but glomerular filtration rate, kidney weight, proteinuria, and morphological evidence of glomerular injury were not affected. In the second study, male spontaneously hypertensive rats underwent uninephrectomy at 5 weeks of age and were followed for 6 months, during which they received no therapy or amlodipine. The drug dose was determined in preliminary studies to be the highest dose not associated with marked growth retardation. Again, although systemic blood pressure was significantly reduced by amlodipine, proteinuria and the prevalence of glomerulosclerosis were similar in amlodipine-treated and control spontaneously hypertensive rats. Micropuncture studies revealed that glomerular pressure remained elevated in amlodipine-treated spontaneously hypertensive rats. Kidney weight and glomerular volume were also similar in amlodipine-treated and control rats. Amlodipine also failed to inhibit platelet aggregation. Therefore, antihypertensive therapy with amlodipine fails to reduce glomerular pressure in spontaneously hypertensive rats as well as glomerular size and injury in spontaneously hypertension rats and desoxycorticosterone-salt hypertension. Although other dihydropyridine calcium antagonists have been found to reduce experimental glomerular injury, these data suggest that amlodipine may not prevent hypertensive nephrosclerosis.
Key Words: hemodynamics • calcium channel blocker • hypertrophy • glomerular sclerosis • rats, inbred SHR • mineralocorticoid
This article has been cited by other articles:
 |
|
 |
|
  A. Jadhav, E. Torlakovic, and J. F. Ndisang Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats Am J Physiol Renal Physiol, March 1, 2009; 296(3): F521 - F534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Shen, M. Hagiwara, Y.-Y. Yao, L. Chao, and J. Chao Salutary Effect of Kallistatin in Salt-Induced Renal Injury, Inflammation, and Fibrosis via Antioxidative Stress Hypertension, May 1, 2008; 51(5): 1358 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hayashi, S. Wakino, N. Sugano, Y. Ozawa, K. Homma, and T. Saruta Ca2+ Channel Subtypes and Pharmacology in the Kidney Circ. Res., February 16, 2007; 100(3): 342 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Clozel, P. Hess, C. Qiu, S.-S. Ding, and M. Rey The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1115 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Khosla and G. Bakris Lessons Learned from Recent Hypertension Trials about Kidney Disease Clin. J. Am. Soc. Nephrol., March 1, 2006; 1(2): 229 - 235. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rahman, S. Pressel, B. R. Davis, C. Nwachuku, J. T. Wright Jr, P. K. Whelton, J. Barzilay, V. Batuman, J. H. Eckfeldt, M. Farber, et al. Renal Outcomes in High-Risk Hypertensive Patients Treated With an Angiotensin-Converting Enzyme Inhibitor or a Calcium Channel Blocker vs a Diuretic: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Arch Intern Med, April 25, 2005; 165(8): 936 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Herlitz, K. Harris, T. Risler, G. Boner, J. Bernheim, J. Chanard, and M. Aurell The effects of an ACE inhibitor and a calcium antagonist on the progression of renal disease: the Nephros Study Nephrol. Dial. Transplant., November 1, 2001; 16(11): 2158 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Griffin, M. Picken, G. L. Bakris, and A. K. Bidani Comparative Effects of Selective T- and L-Type Calcium Channel Blockers in the Remnant Kidney Model Hypertension, May 1, 2001; 37(5): 1268 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dobrzynski, C. Wang, J. Chao, and L. Chao Adrenomedullin Gene Delivery Attenuates Hypertension, Cardiac Remodeling, and Renal Injury in Deoxycorticosterone Acetate-Salt Hypertensive Rats Hypertension, December 1, 2000; 36(6): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sabbatini, A. Leonardi, R. Testa, L. Vitaioli, and F. Amenta Effect of Calcium Antagonists on Glomerular Arterioles in Spontaneously Hypertensive Rats Hypertension, March 1, 2000; 35(3): 775 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Karam, J.-P. Clozel, P. Bruneval, M.-F. Gonzalez, and J. Menard Contrasting Effects of Selective T- and L-Type Calcium Channel Blockade on Glomerular Damage in DOCA Hypertensive Rats Hypertension, October 1, 1999; 34(4): 673 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Toblli, L. Ferder, M. Angerosa, and F. Inserra Effects of Amlodipine on Tubulointerstitial Lesions in Normotensive Hyperoxaluric Rats Hypertension, October 1, 1999; 34(4): 854 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakamura, H. Ono, and E. D. Frohlich Differential Effects of T- and L-Type Calcium Antagonists on Glomerular Dynamics in Spontaneously Hypertensive Rats Hypertension, August 1, 1999; 34(2): 273 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Francischetti, H. Ono, and E. D. Frohlich Renoprotective Effects of Felodipine and/or Enalapril in Spontaneously Hypertensive Rats With and Without L-NAME Hypertension, March 1, 1998; 31(3): 795 - 801. [Abstract] [Full Text] [PDF]
|
|