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(Hypertension. 1996;27:442-448.)
© 1996 American Heart Association, Inc.

Articles

Acute Baroreflex Resetting

Differential Control of Pressure and Nerve Activity

Heather A. Drummond; Jeanne L. Seagard

From the Zablocki Department of Veterans Affairs Medical Center and Departments of Anesthesiology and Physiology, The Medical College of Wisconsin, Milwaukee.

Correspondence to Heather A. Drummond, PhD, Medical College of Wisconsin, Milwaukee, WI 53226. E-mail hdrummon@post.its.mcw.edu.

Abstract This study evaluated acute resetting of carotid baroreflex control of arterial blood pressure and renal or thoracic sympathetic nerve activity in thiopental-anesthetized mongrel dogs with the use of a vascularly isolated carotid sinus preparation, the experimental model used previously to characterize acute resetting in carotid baroreceptor afferent fibers. Carotid baroreceptors were conditioned with a pulsatile pressure for 20 minutes at three pressure ranges: low (50 to 75 mm Hg), mid (100 to 125), or high (150 to 175). Blood pressure and nerve activity were recorded in response to slow ramp increases in sinus pressure; nonlinear regression and best-fit analyses were used for determination of curve fit parameters of the blood pressure and nerve activity versus sinus pressure response curves. Carotid sinus pressure thresholds for blood pressure and renal nerve activity responses at all conditioning pressures were significantly different; however, only the pressure threshold for thoracic nerve activity at the low conditioning pressure was significantly different from the responses at other conditioning pressures. Average renal activity resetting (0.506±0.072) was significantly greater than blood pressure resetting (0.335±0.046) in the same dogs, and thoracic activity (0.200±0.057) was not different from blood pressure resetting (0.194±0.031) in the same dogs. In a previous investigation, our laboratory has demonstrated that type 1 carotid baroreceptors acutely reset at a value of about 0.15. These results indicate that (1) renal and thoracic nerve activities and blood pressure acutely reset to a greater degree than type 1 carotid baroreceptors and that (2) renal activity acutely resets to a greater degree than blood pressure and thoracic nerve activity.

Key Words: carotid sinus • sympathetic nerve activity • thoracic nerves • pressoreceptors

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