This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Daniels, S. R. Articles by Morrison, J. A. Search for Related Content PubMed PubMed Citation Articles by Daniels, S. R. Articles by Morrison, J. A.

(Hypertension. 1996;28:37-41.)
© 1996 American Heart Association, Inc.

Articles

Correlates of the Hemodynamic Determinants of Blood Pressure

Stephen R. Daniels; Thomas R. Kimball; Philip Khoury; Sandra Witt; John A. Morrison

the Division of Cardiology, Department of Pediatrics, University of Cincinnati, College of Medicine, and the Children's Hospital Medical Center, Cincinnati, Ohio.

The purpose of this study was to investigate the association of sex, race, lean body mass, and fat mass with the hemodynamic determinants of blood pressure, including stroke volume, heart rate, and total peripheral vascular resistance. The study included 201 subjects aged 6 to 17 years, 105 of whom were male and 98 of whom were black. Lean body mass and fat mass were both significant (P<.05) independent determinants of stroke volume, cardiac output, and total peripheral vascular resistance. However, the direction of the effect of lean body mass was opposite for stroke volume and cardiac output compared with that of total peripheral vascular resistance. The direct relationship of lean body mass with systolic blood pressure (SBP) and diastolic blood pressure (DBP) (regression coefficients, 0.55±0.05 for SBP and 0.47±0.05 for DBP) indicates that the effect of lean body mass on cardiac output may predominate. Lean body mass explained substantially more of the variance of the hemodynamic variables than did fat mass. After control for the effects of body size, male subjects had higher heart rate and cardiac output, and female subjects had higher vascular resistance. White subjects had higher stroke volume and cardiac output, and black subjects had higher peripheral vascular resistance. This study demonstrates that lean body mass is a more important correlate of the hemodynamic determinants of blood pressure than is fat mass and that sex and race have significant independent relationships with the hemodynamic determinants of blood pressure in children and adolescents.

Key Words: hemodynamics • obesity • ethnic groups • adolescents • cardiac output • heart rate • vascular resistance

This article has been cited by other articles:

				C. Syme, M. Abrahamowicz, G. T. Leonard, M. Perron, L. Richer, S. Veillette, Y. Xiao, D. Gaudet, T. Paus, and Z. Pausova Sex Differences in Blood Pressure and Its Relationship to Body Composition and Metabolism in Adolescence Arch Pediatr Adolesc Med, September 1, 2009; 163(9): 818 - 825. [Abstract] [Full Text] [PDF]

				Authors/Task Force Members:, G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A. M. Heagerty, S. E. Kjeldsen, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) Eur. Heart J., June 11, 2007; (2007) ehm236v1. [Full Text] [PDF]

				S. R. Daniels, J. A. Morrison, D. L. Sprecher, P. Khoury, and T. R. Kimball Association of Body Fat Distribution and Cardiovascular Risk Factors in Children and Adolescents Circulation, February 2, 1999; 99(4): 541 - 545. [Abstract] [Full Text] [PDF]

				B. Falkner, S. Hulman, and H. Kushner Birth Weight Versus Childhood Growth as Determinants of Adult Blood Pressure Hypertension, January 1, 1998; 31(1): 145 - 150. [Abstract] [Full Text] [PDF]