This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Struijker-Boudier, H. A.J. Articles by Levy, B. I. Search for Related Content PubMed PubMed Citation Articles by Struijker-Boudier, H. A.J. Articles by Levy, B. I.

(Hypertension. 1996;28:779-784.)
© 1996 American Heart Association, Inc.

Articles

Disproportional Arterial Hypertrophy in Hypertensive mRen-2 Transgenic Rats

Harry A.J. Struijker-Boudier; Helma van Essen; Gregorio Fazzi; Jo G.R. De Mey; Hong Ying Qiu; Bernard I. Levy

the Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Limburg (the Netherlands) (H.A.J.S.-B., H. van E., G.F., J.G.R. De M.), and INSERM Unite 141, Hopital Lariboisiere, Paris, France (Y.Q., B.I.L.).

Correspondence to Harry A.J. Struijker-Boudier, Department of Pharmacology, University of Limburg, PO Box 616, 6200 MD Maastricht, Netherlands. E-mail h.struijkerboudier@farmaco.rulimburg.nl.

In the present study, we investigated the role of enhanced vascular renin-angiotensin activity in vascular hypertrophy. We used transgenic (mRen-2)27 (renin TGR) rats, spontaneously hypertensive rats (SHR), and their respective normotensive control rats to study in situ pressure-diameter relationships in second-generation mesenteric arterial branches (in vivo diameter, 400 to 500 µm) over a pressure range of 0 to 200 mm Hg. We studied pressure-diameter curves under both control (Tyrode's solution) and fully relaxed (Tyrode's solution containing 100 mg/L potassium cyanide) conditions. From these curves, we determined mechanical properties at operating blood pressure. In both hypertensive strains, mesenteric arterial media cross-sectional area was increased, with a significantly (P<.05) stronger degree of hypertrophy in renin TGR rats. Arterial distensibility of relaxed vessels was decreased to an equal degree in both hypertensive strains. Under control conditions, distensibility was higher in SHR than in renin TGR rats but still significantly reduced compared with distensibility in normotensive rats. Wall tension was increased to an equal degree in both hypertensive strains, whereas circumferential wall stress was normal in SHR but significantly (P<.05) reduced in renin TGR rats. These results indicate that whereas vascular hypertrophy in SHR causes adaptive normalization of arterial wall stress, enhanced vascular renin-angiotensin activity causes vascular hypertrophy in excess of the hypertrophy associated with pressure elevation alone.

Key Words: renin-angiotensin system • hypertension, genetic • rats, transgenic • rats, inbred SHR • arteries • hypertrophy • compliance

This article has been cited by other articles:

				F. Feihl, L. Liaudet, B. I. Levy, and B. Waeber Hypertension and microvascular remodelling Cardiovasc Res, May 1, 2008; 78(2): 274 - 285. [Abstract] [Full Text] [PDF]

				M. C. Blendea, D. Jacobs, C. S. Stump, S. I. McFarlane, C. Ogrin, G. Bahtyiar, S. Stas, P. Kumar, Q. Sha, C. M. Ferrario, et al. Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E353 - E359. [Abstract] [Full Text] [PDF]

				J. P. M. Wesselman, A. D. Dobrian, S. D. Schriver, and R. L. Prewitt Src Tyrosine Kinases and Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinases Mediate Pressure-Induced C-Fos Expression in Cannulated Rat Mesenteric Small Arteries Hypertension, March 1, 2001; 37(3): 955 - 960. [Abstract] [Full Text] [PDF]

				G. P. Rossi, A. Sacchetto, D. Rizzoni, S. Bova, E. Porteri, G. Mazzocchi, A. S. Belloni, M. Bahcelioglu, G. G. Nussdorfer, and A. C. Pessina Blockade of Angiotensin II Type 1 Receptor and Not of Endothelin Receptor Prevents Hypertension and Cardiovascular Disease in Transgenic (mREN2)27 Rats via Adrenocortical Steroid-Independent Mechanisms Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 949 - 956. [Abstract] [Full Text] [PDF]

				F. R. L. Crijns, B. H. R. Wolffenbuttel, J. G. R. de Mey, and H. A. J. S. Boudier Mechanical properties of mesenteric arteries in diabetic rats: consequences of outward remodeling Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1672 - H1677. [Abstract] [Full Text] [PDF]

				S. M. Jacinto, J. J. Mullins, and K. D. Mitchell Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats Am J Physiol Renal Physiol, February 1, 1999; 276(2): F315 - F322. [Abstract] [Full Text] [PDF]

				F. Pourageaud and J. G. R. De Mey Structural properties of rat mesenteric small arteries after 4-wk exposure to elevated or reduced blood flow Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1699 - H1706. [Abstract] [Full Text] [PDF]