| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 1996;28:881-887.)
© 1996 American Heart Association, Inc.
Articles |
Polymorphisms of the Transforming Growth Factor-ß1 Gene in Relation to Myocardial Infarction and Blood Pressure
The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study
INSERM SC7, Paris, France (F.C., S.R., C.M., O.P.); UMR 103 CNRS-Biomerieux, ENS, Lyon, France (A.T., L.G.); and the MONItoring of trends and determinants in CArdiovascular disease (MONICA) Projects of Belfast, UK (A.E.), and Strasbourg (D.A.), Lille (G.L.), and Toulouse (J.-B.R.), France.
Correspondence to Francois Cambien, INSERM SC7, 17 rue du Fer a Moulin, 75005 Paris, France. E-mail cambien@infobiogen.fr.
Transforming growth factor-ß1 (TGF-ß1) plays an important role in the modulation of cellular growth and differentiation and the production and degradation of the extracellular matrix. A number of experimental results suggest that TGF-ß1 may be involved in cardiovascular physiopathology. In the present study, we assessed whether the TGF-ß1 gene is a candidate gene for coronary heart disease or hypertension. We screened the coding region and 2181 bp upstream of the TGF-ß gene for polymorphisms and identified seven polymorphisms: 3 in the upstream region of the gene at positions -988, -800, and -509 from the first transcribed nucleotide; 1 in a nontranslated region at position +72; 2 in the signal peptide sequence Leu10
Pro, Arg25Pro; and 1 in the region of the gene coding for the precursor part of the protein not present in the active form, Thr263Ile. We analyzed these TGF-ß1 polymorphisms in 563 patients with myocardial infarction and 629 control subjects from four regions in Northern Ireland and France. The Pro25 allele was more frequent in patients than in control subjects in Belfast (P<.01) and Strasbourg (P<.05). The TGF-ß1 polymorphisms were not associated with the degree of angiographically assessed coronary artery disease in patients. The presence of a Pro25 allele was associated with a lower systolic pressure in the four control groups (P<.002), and a history of hypertension was significantly less frequent in homozygotes or heterozygotes for Pro25 than in homozygotes for Arg25 (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.92; P<.03). Since the Pro25 allele was associated with an increased risk of myocardial infarction and a reduced risk of hypertension, we favor a cautious interpretation of these apparently inconsistent results. Other studies will need to verify whether these associations are real.
Key Words: transforming growth factors • myocardial infarction • polymorphism, genetic
This article has been cited by other articles:
 |
|
 |
|
  G. Dell'Omo, G. Penno, L. Pucci, D. Lucchesi, S. Del Prato, and R. Pedrinelli Lack of association between TGF-{beta}-1 genotypes and microalbuminuria in essential hypertensive men Nephrol. Dial. Transplant., June 1, 2009; 24(6): 1864 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. F. Panoulas, K. M. J. Douglas, J. P. Smith, A. Stavropoulos-Kalinoglou, G. S. Metsios, P. Nightingale, and G. D. Kitas Transforming growth factor-{beta}1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis Rheumatology, February 1, 2009; 48(2): 113 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Chang, C.-J. Chen, F.-C. Tsai, H.-M. Lai, P.-C. Tsai, M.-H. Tsai, and Y.-C. Ko Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor {beta}1 gene Rheumatology, May 1, 2008; 47(5): 617 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Saltzman, J. F. Yamamoto, R. Decker, L. Yokochi, A. G. Theriault, T. M. Vogt, and L. Le Marchand Association of Genetic Variation in the Transforming Growth Factor {beta}-1 Gene with Serum Levels and Risk of Colorectal Neoplasia Cancer Res., February 15, 2008; 68(4): 1236 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hatta, A. Morimoto, E. Ishii, H. Kimura, I. Ueda, S. Hibi, S. Todo, T. Sugimoto, and S. Imashuku Association of transforming growth factor-{beta}1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases Haematologica, November 1, 2007; 92(11): 1470 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Jonth, L. Silveira, T. E. Fingerlin, H. Sato, J. C. Luby, K. I. Welsh, C. S. Rose, L. S. Newman, R. M. du Bois, L. A. Maier, et al. TGF-beta1 Variants in Chronic Beryllium Disease and Sarcoidosis J. Immunol., September 15, 2007; 179(6): 4255 - 4262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thys, I. Schrauwen, K. Vanderstraeten, K. Janssens, N. Dieltjens, K. Van Den Bogaert, E. Fransen, W. Chen, M. Ealy, M. Claustres, et al. The coding polymorphism T263I in TGF-{beta}1 is associated with otosclerosis in two independent populations Hum. Mol. Genet., September 1, 2007; 16(17): 2021 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Berndt, W.-Y. Huang, N. Chatterjee, M. Yeager, R. Welch, S. J. Chanock, J. L. Weissfeld, R. E. Schoen, and R. B. Hayes Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma Carcinogenesis, September 1, 2007; 28(9): 1965 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kang, K.-M. Lee, S. K. Park, S. I. Berndt, D. Reding, N. Chatterjee, R. Welch, S. Chanock, W.-Y. Huang, and R. B. Hayes Lack of Association of Transforming Growth Factor-{beta}1 Polymorphisms and Haplotypes with Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Trial Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1303 - 1305. [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Grainger TGF-{beta} and atherosclerosis in man Cardiovasc Res, May 1, 2007; 74(2): 213 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kim and C. Lee The Gene Encoding Transforming Growth Factor {beta}1 Confers Risk of Ischemic Stroke and Vascular Dementia Stroke, November 1, 2006; 37(11): 2843 - 2845. [Full Text] [PDF]
|
|
|
|
|
|
M. P.S. Sie, A. G. Uitterlinden, M. J. Bos, P. P. Arp, M. M.B Breteler, P. J. Koudstaal, H. A.P. Pols, A. Hofman, C. M. van Duijn, and J. C.M. Witteman TGF-{beta}1 Polymorphisms and Risk of Myocardial Infarction and Stroke: The Rotterdam Study Stroke, November 1, 2006; 37(11): 2667 - 2671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. August and M. Suthanthiran Transforming growth factor beta signaling, vascular remodeling, and hypertension. N. Engl. J. Med., June 22, 2006; 354(25): 2721 - 2723. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Mao, E. F. Saunier, J. P. de Koning, M. M. McKinnon, M. N. Higgins, K. Nicklas, H.-T. Yang, A. Balmain, and R. J. Akhurst Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility PNAS, May 23, 2006; 103(21): 8125 - 8130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Koch, P. Hoppmann, J. C. Mueller, A. Schomig, and A. Kastrati Association of Transforming Growth Factor-{beta}1 Gene Polymorphisms With Myocardial Infarction in Patients With Angiographically Proven Coronary Heart Disease Arterioscler Thromb Vasc Biol, May 1, 2006; 26(5): 1114 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Summers, B. M. Coupes, M. F. Brennan, S. A. Ralph, C. D. Short, and P. E. C. Brenchley VEGF -460 genotype plays an important role in progression to chronic kidney disease stage 5 Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2427 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Hamaguchi, S Okino, N Sodeyama, Y Itoh, A Takahashi, E Otomo, M Matsushita, H Mizusawa, and M Yamada Association of a polymorphism of the transforming growth factor-{beta}1 gene with cerebral amyloid angiopathy J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 696 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Kaklamani, L. Baddi, J. Liu, D. Rosman, S. Phukan, C. Bradley, C. Hegarty, B. McDaniel, A. Rademaker, C. Oddoux, et al. Combined Genetic Assessment of Transforming Growth Factor-{beta} Signaling Pathway Variants May Predict Breast Cancer Risk Cancer Res., April 15, 2005; 65(8): 3454 - 3461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M van der Paardt, J B A Crusius, M A Garcia-Gonzalez, B A C Dijkmans, A S Pena, and I E van der Horst-Bruinsma Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor {beta}1 (TGFB1) gene polymorphisms Ann Rheum Dis, April 1, 2005; 64(4): 616 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sparks, J. Bigler, J. G Sibert, J. D Potter, Y. Yasui, and C. M Ulrich TGF{beta}1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps Int. J. Epidemiol., October 1, 2004; 33(5): 955 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ewart-Toland, J. M. Chan, J. Yuan, A. Balmain, and J. Ma A Gain of Function TGFB1 Polymorphism May Be Associated With Late Stage Prostate Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 759 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Grainger Transforming Growth Factor {beta} and Atherosclerosis: So Far, So Good for the Protective Cytokine Hypothesis Arterioscler Thromb Vasc Biol, March 1, 2004; 24(3): 399 - 404. [Abstract] [Full Text]
|
|
|
|
 |
|
 L Wu, J Chau, R P Young, V Pokorny, G D Mills, R Hopkins, L McLean, and P N Black Transforming growth factor-{beta}1 genotype and susceptibility to chronic obstructive pulmonary disease Thorax, February 1, 2004; 59(2): 126 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, T. Habuchi, N. Tsuchiya, K. Mitsumori, L. Wang, C. Ohyama, K. Sato, T. Kamoto, O. Ogawa, and T. Kato Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10 Carcinogenesis, February 1, 2004; 25(2): 237 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jaakkola, A. M. Crane, K. Laiho, I. Herzberg, A.-M. Sims, L. Bradbury, A. Calin, S. Brophy, M. Kauppi, K. Kaarela, et al. The effect of transforming growth factor {beta}1 gene polymorphisms in ankylosing spondylitis Rheumatology, January 1, 2004; 43(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Levesque, J.-M. Moutquin, C. Lindsay, M.-C. Roy, and F. Rousseau Implication of an AGT Haplotype in a Multigene Association Study With Pregnancy Hypertension Hypertension, January 1, 2004; 43(1): 71 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Xaubet, A. Marin-Arguedas, S. Lario, J. Ancochea, F. Morell, J. Ruiz-Manzano, E. Rodriguez-Becerra, J. M. Rodriguez-Arias, P. Inigo, S. Sanz, et al. Transforming Growth Factor-{beta}1 Gene Polymorphisms Are Associated with Disease Progression in Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., August 15, 2003; 168(4): 431 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tang, M. L. McKinnon, L. M. Leong, S. A. B. Rusholme, S. Wang, and R. J. Akhurst Genetic modifiers interact with maternal determinants in vascular development of Tgfb1-/- mice Hum. Mol. Genet., July 1, 2003; 12(13): 1579 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dunning, P. D. Ellis, S. McBride, H. L Kirschenlohr, C. S. Healey, P. R. Kemp, R. N. Luben, J. Chang-Claude, A. Mannermaa, V. Kataja, et al. A Transforming Growth Factor{beta}1 Signal Peptide Variant Increases Secretion in Vitro and Is Associated with Increased Incidence of Invasive Breast Cancer Cancer Res., May 15, 2003; 63(10): 2610 - 2615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Schotte, P Willeke, S Rust, G Assmann, W Domschke, M Gaubitz, and B Schluter The transforming growth factor-{beta}1 gene polymorphism (G915C) is not associated with systemic lupus erythematosus Lupus, February 1, 2003; 12(2): 86 - 92. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Lynch, L. Wagoner, S. Li, L. Sparks, J. Molkentin, and G. W. Dorn II Novel and nondetected human signaling protein polymorphisms Physiol Genomics, September 3, 2002; 10(3): 159 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J P Pandey and E C LeRoy A profibrotic polymorphism (of TGF{beta}1) in systemic sclerosis Ann Rheum Dis, August 1, 2002; 61(8): 671 - 672. [Full Text] [PDF]
|
|
|
|
|
|
A Crilly, J Hamilton, C J Clark, A Jardine, and R Madhok Analysis of transforming growth factor {beta}1 gene polymorphisms in patients with systemic sclerosis Ann Rheum Dis, August 1, 2002; 61(8): 678 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Araria-Goumidi, J C Lambert, D M A Mann, C Lendon, B Frigard, T Iwatsubo, D Cottel, P Amouyel, and M C Chartier-Harlin Association study of three polymorphisms of TGF-{beta}1 gene with Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, July 1, 2002; 73(1): 62 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chiu, M.-L. Chang, C.-P. Chiang, L.-J. Hahn, L.-L. Hsieh, and C.-J. Chen Interaction of Collagen-related Genes and Susceptibility to Betel Quid-induced Oral Submucous Fibrosis Cancer Epidemiol. Biomarkers Prev., July 1, 2002; 11(7): 646 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. BAYAT, A. ALANSAR, A. H. HAJEER, M. SHAH, J. S. WATSON, J. K. STANLEY, M. W. J. FERGUSON, and W. E. R. OLLIER Genetic Susceptibility in Dupuytren's Disease: Lack of Association of a Novel Transforming Growth Factor {beta}2 Polymorphism in Dupuytren's Disease J Hand Surg Eur Vol., February 1, 2002; 27(1): 47 - 49. [Abstract] [PDF]
|
|
|
|
 |
|
 F Andreotti, I Porto, F Crea, and A Maseri Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies Heart, February 1, 2002; 87(2): 107 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Rivera, M. Echegaray, T. Rankinen, L. Perusse, T. Rice, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, et al. TGF-{beta}1 gene-race interactions for resting and exercise blood pressure in the HERITAGE Family Study J Appl Physiol, October 1, 2001; 91(4): 1808 - 1813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ziv, J. Cauley, P. A. Morin, R. Saiz, and W. S. Browner Association Between the T29->C Polymorphism in the Transforming Growth Factor {beta}1 Gene and Breast Cancer Among Elderly White Women: The Study of Osteoporotic Fractures JAMA, June 13, 2001; 285(22): 2859 - 2863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Keen, H. Snieder, H. Molloy, J. Daniels, M. Chiano, F. Gibson, L. Fairbairn, P. Smith, A. J. MacGregor, D. Gewert, et al. Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor {beta}1 gene and hip bone mineral density: a study of female twins Rheumatology, January 1, 2001; 40(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yokota, S. Ichihara, T.-L. Lin, N. Nakashima, and Y. Yamada Association of a T29->C Polymorphism of the Transforming Growth Factor-{beta}1 Gene With Genetic Susceptibility to Myocardial Infarction in Japanese Circulation, June 20, 2000; 101(24): 2783 - 2787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tiret, C. Mallet, O. Poirier, V. Nicaud, A. Millaire, J.-B. Bouhour, G.e. Roizes, M. Desnos, R. Dorent, K. Schwartz, et al. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: The CARDIGENE study J. Am. Coll. Cardiol., January 1, 2000; 35(1): 29 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lario, P. Inigo, J. M. Campistol, E. Poch, F. Rivera, and F. Oppenheimer Restriction Enzyme-based Method for Transforming Growth Factor-{beta}1 Genotyping: Nonisotopic Detection of Polymorphisms in Codons 10 and 25 and the 5'-Flanking Region Clin. Chem., August 1, 1999; 45(8): 1290 - 1292. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pahor, M. B. Elam, R. J. Garrison, S. B. Kritchevsky, and W. B. Applegate Emerging Noninvasive Biochemical Measures to Predict Cardiovascular Risk Arch Intern Med, February 8, 1999; 159(3): 237 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, A. Khanna, V. Sharma, T. Singh, M. Suthanthiran, and P. August TGF-ß1 DNA Polymorphisms, Protein Levels, and Blood Pressure Hypertension, January 1, 1999; 33(1): 271 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Re and E. D. Frohlich Controversies in the Genetic Analysis of Hypertensive Diseases Hypertension, November 1, 1996; 28(5): 880 - 880. [Full Text]
|
|
|
|
|
|
M. Suthanthiran, B. Li, J. O. Song, R. Ding, V. K. Sharma, J. E. Schwartz, and P. August Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage PNAS, March 28, 2000; 97(7): 3479 - 3484. [Abstract] [Full Text] [PDF]
|
|