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(Hypertension. 1996;28:1123-1125.)
© 1996 American Heart Association, Inc.

Articles

Angiotensinogen in Human Essential Hypertension

Mark Caulfield; Paul Lavender; John Newell-Price; Sejal Kamdar; Martin Farrall; Adrian J.L. Clark

the Departments of Clinical Pharmacology (M.C., S.K.) and Molecular Endocrinology/Endocrinology (J.N.-P., P.L., A.J.L.C.), St Bartholomew's Hospital, London, and The Wellcome Trust Centre for Human Genetics, Windmill Road, Oxford (M.F.), UK.

The candidacy of angiotensinogen for a role in the genetic basis of hypertension is supported by the observation that plasma angiotensinogen levels track with raised blood pressure through families. In addition, transgenic mice with overexpression of a rat angiotensinogen gene develop hypertension, and knockout mice with a disrupted gene and absent angiotensinogen production develop low blood pressure. There are now two studies in populations of white European origin and one in African Caribbeans providing support for a role of the angiotensinogen gene locus in human essential hypertension.

Key Words: angiotensinogen • genetics • hypertension, essential

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