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(Hypertension. 1997;29:49.)
© 1997 American Heart Association, Inc.

Research Articles (Issue 1, Part 1)

Absence of Linkage for ‘Endothelial’ Nitric Oxide Synthase Locus to Blood Pressure in Dahl Rats

Alan Y. Deng; John P. Rapp

the Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo.

Correspondence to Alan Y. Deng, PhD, Department of Physiology and Molecular Medicine, Medical College of Ohio, PO Box 10008, Toledo, OH 43699-0008. E-mail: adeng@vortex.mco.edu.

Nitric oxide is thought to be involved in blood pressure regulation. Nitric oxide synthase (NOS) genes are logical candidates for genetic hypertension. Of the three known forms of NOS, the "neuronal" and "inducible" Nos genes have been tested as candidate genes for causing inherited hypertension in Dahl salt-sensitive rats. In the present work, we analyzed the endothelial Nos gene, designated Nos3, directly and indirectly for cosegregation with blood pressure in six F₂ populations independently generated from crosses of Dahl salt-sensitive rats with rats of various other strains. The Nos3 alleles did not cosegregate with blood pressure in these populations. Therefore, Nos3 is an improbable, if not impossible, candidate gene for causing hypertension in the Dahl salt-sensitive rat.

Key Words: hypertension, genetic • rats, Dahl • nitric oxide synthase • genetics • blood pressure

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