(Hypertension. 1997;29:1025-1030.)
© 1997 American Heart Association, Inc.
Articles |
Two-Kidney, One Clip and One-Kidney, One Clip Hypertension in Mice
From the Division of Hypertension, University of Lausanne (Switzerland) Medical School.
Correspondence to Thierry Pedrazzini, PhD, Division of Hypertension, University of Lausanne Medical School, CH-1011 Lausanne, Switzerland. E-mail thierry.pedrazzini{at}chuv.hospvd.ch
Abstract The mouse remains the animal of choice in transgenic experiments, creating a need for methods of evaluating the physiology of genetically modified animals. We have established and characterized two murine models of renovascular hypertension known as the two-kidney, one clip and one-kidney, one clip models. The appropriate size of the clip lumen needed to induce high blood pressure was determined to be 0.12 mm. Clips with a lumen of 0.11 mm induced a high percentage of renal infarction, and clips with a 0.13-mm opening did not produce hypertension. Four weeks after clipping, two-kidney, one clip hypertensive mice exhibited blood pressure approximately 20 mm Hg higher than their sham-operated controls. After a similar period, this increase reached almost 35 mm Hg in the one-kidney, one clip model. Depending on the model, mice develop either renin-dependent or renin-independent hypertension. Both models are characterized by the development of cardiovascular hypertrophy.
Key Words: hypertension, renovascular • mice, transgenic • renin • heart • hypertrophy
This article has been cited by other articles:
 |
|
 |
|
  D. M. Harris, H. I. Cohn, S. Pesant, R.-H. Zhou, and A. D. Eckhart Vascular smooth muscle Gq signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3072 - H3079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Wagenseil, R. H. Knutsen, D. Y. Li, and R. P. Mecham Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H574 - H582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Jung, S. L. Marklund, N. Xia, R. Busse, and R. P. Brandes Inactivation of Extracellular Superoxide Dismutase Contributes to the Development of High-Volume Hypertension Arterioscler. Thromb. Vasc. Biol., March 1, 2007; 27(3): 470 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhu, J. Feng, E. Lucchinetti, G. Fischer, L. Xu, T. Pedrazzini, M. C. Schaub, and M. Zaugg Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway Cardiovasc Res, October 1, 2006; 72(1): 152 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M.P. Arruda, V. A. Peotta, S. S. Meyrelles, and E. C. Vasquez Evaluation of Vascular Function in Apolipoprotein E Knockout Mice With Angiotensin-Dependent Renovascular Hypertension Hypertension, October 1, 2005; 46(4): 932 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hiyoshi, K. Yayama, M. Takano, and H. Okamoto Angiotensin Type 2 Receptor-Mediated Phosphorylation of eNOS in the Aortas of Mice With 2-Kidney, 1-Clip Hypertension Hypertension, May 1, 2005; 45(5): 967 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lazartigues, A. J. Lawrence, F. S. Lamb, and R. L. Davisson Renovascular Hypertension in Mice With Brain-Selective Overexpression of AT1a Receptors Is Buffered by Increased Nitric Oxide Production in the Periphery Circ. Res., September 3, 2004; 95(5): 523 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mazzolai, M. A. Duchosal, M. Korber, K. Bouzourene, J. F. Aubert, H. Hao, V. Vallet, H. R. Brunner, J. Nussberger, G. Gabbiani, et al. Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE-/- Mice Hypertension, September 1, 2004; 44(3): 277 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Jung, J.G. Schreiber, H. Geiger, T. Pedrazzini, R. Busse, and R.P. Brandes gp91phox-Containing NADPH Oxidase Mediates Endothelial Dysfunction in Renovascular Hypertension Circulation, April 13, 2004; 109(14): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Jung, S. L. Marklund, H. Geiger, T. Pedrazzini, R. Busse, and R. P. Brandes Extracellular Superoxide Dismutase Is a Major Determinant of Nitric Oxide Bioavailability: In Vivo and Ex Vivo Evidence From ecSOD-Deficient Mice Circ. Res., October 3, 2003; 93(7): 622 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Chen, S.-F. Yet, and M. A. Perrella Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function Experimental Biology and Medicine, May 1, 2003; 228(5): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervenka, V. Horacek, I. Vaneckova, J. A. Hubacek, M. I. Oliverio, T. M. Coffman, and L. G. Navar Essential Role of AT1A Receptor in the Development of 2K1C Hypertension Hypertension, November 1, 2002; 40(5): 735 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fuchs, S. Germain, J. Philippe, P. Corvol, and F. Pinet Expression of Renin in Large Arteries Outside the Kidney Revealed by Human Renin Promoter/LacZ Transgenic Mouse Am. J. Pathol., August 1, 2002; 161(2): 717 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, E. Hummler, J. Nussberger, S. Clement, G. Gabbiani, H. R. Brunner, and M. Burnier Blood Pressure, Cardiac, and Renal Responses to Salt and Deoxycorticosterone Acetate in Mice: Role of Renin Genes J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1509 - 1516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Duplain, R. Burcelin, C. Sartori, S. Cook, M. Egli, M. Lepori, P. Vollenweider, T. Pedrazzini, P. Nicod, B. Thorens, et al. Insulin Resistance, Hyperlipidemia, and Hypertension in Mice Lacking Endothelial Nitric Oxide SynthaseNote Added in Proof Circulation, July 17, 2001; 104(3): 342 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. PRADERVAND, Q. WANG, M. BURNIER, F. BEERMANN, J. D. HORISBERGER, E. HUMMLER, and B. C. ROSSIER A Mouse Model for Liddle's Syndrome J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2527 - 2533. [Abstract] [Full Text]
|
|
|
|
|
|
X.-P. Yang, Y.-H. Liu, N.-E. Rhaleb, N. Kurihara, H. E. Kim, and O. A. Carretero Echocardiographic assessment of cardiac function in conscious and anesthetized mice Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1967 - H1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Haefliger, P. Meda, A. Formenton, P. Wiesel, A. Zanchi, H. R. Brunner, P. Nicod, and D. Hayoz Aortic Connexin43 Is Decreased During Hypertension Induced by Inhibition of Nitric Oxide Synthase Arterioscler. Thromb. Vasc. Biol., July 1, 1999; 19(7): 1615 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pradervand, P. M. Barker, Q. Wang, S. A. Ernst, F. Beermann, B. R. Grubb, M. Burnier, A. Schmidt, R. J. M. Bindels, J. T. Gatzy, et al. Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta -subunit of the amiloride-sensitive epithelial sodium channel PNAS, February 16, 1999; 96(4): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Madeddu, A. F. Milia, M. B. Salis, L. Gaspa, W. Gross, A. Lippoldt, and C. Emanueli Renovascular Hypertension in Bradykinin B2-Receptor Knockout Mice Hypertension, September 1, 1998; 32(3): 503 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A Doevendans, M. J. Daemen, E. D de Muinck, and J. F Smits Cardiovascular phenotyping in mice Cardiovasc Res, July 1, 1998; 39(1): 34 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M Pinto, M. Paul, and D. Ganten Lessons from rat models of hypertension: from Goldblatt to genetic engineering Cardiovasc Res, July 1, 1998; 39(1): 77 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mazzolai, J. Nussberger, J.-F. Aubert, D. B. Brunner, G. Gabbiani, H. R. Brunner, and T. Pedrazzini Blood Pressure–Independent Cardiac Hypertrophy Induced by Locally Activated Renin-Angiotensin System Hypertension, June 1, 1998; 31(6): 1324 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cavalli, A.-L. Lattion, E. Hummler, M. Nenniger, T. Pedrazzini, J.-F. Aubert, M. C. Michel, M. Yang, G. Lembo, C. Vecchione, et al. Decreased blood pressure response in mice deficient of the alpha 1b-adrenergic receptor PNAS, October 14, 1997; 94(21): 11589 - 11594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Murat, C. Pellieux, H.-R. Brunner, and T. Pedrazzini Calcineurin Blockade Prevents Cardiac Mitogen-activated Protein Kinase Activation and Hypertrophy in Renovascular Hypertension J. Biol. Chem., December 22, 2000; 275(52): 40867 - 40873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tokuyama, K. Hayashi, H. Matsuda, E. Kubota, M. Honda, K. Okubo, Y. Ozawa, and T. Saruta Stenosis-dependent role of nitric oxide and prostaglandins in chronic renal ischemia Am J Physiol Renal Physiol, May 1, 2002; 282(5): F859 - F865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wiesel, A. P. Patel, I. M. Carvajal, Z. Y. Wang, A. Pellacani, K. Maemura, N. DiFonzo, H. G. Rennke, M. D. Layne, S.-F. Yet, et al. Exacerbation of Chronic Renovascular Hypertension and Acute Renal Failure in Heme Oxygenase-1-Deficient Mice Circ. Res., May 25, 2001; 88(10): 1088 - 1094. [Abstract] [Full Text] [PDF]
|
|