(Hypertension. 1997;29:1213-1217.)
© 1997 American Heart Association, Inc.
Articles |
Age-Related Changes in Total Arterial Capacitance From Birth to Maturity in a Normotensive Population
From the Division of Cardiology, The New York Hospital–Cornell Medical Center, New York (G. de S., M.J.R., R.B.D.); Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy (G. de S., G.M., R.G.); and Children's Hospital Medical Center, Division of Cardiology, Department of Pediatrics, University of Cincinnati (Ohio) (S.R.D., T.R.K.).
Correspondence to Dr Giovanni de Simone, Division of Cardiology, The New York Hospital–Cornell Medical Center, 525 E 68th St, New York, NY 10021. E-mail mjograd{at}mail.med.cornell.edu
Abstract We evaluated the effect of body growth and aging on the ratio of echocardiographic (Teichholz) stroke volume to pulse pressure (SV/PP ratio) in 373 normal-weight, normotensive children to adolescents (1 day to 17 years old; 166 girls, 87 nonwhite) and 393 normal adults (17 to 85 years old; 164 women, 112 nonwhite). Stroke volume increased with age in children (r=.64, P<.0001) and was stable in adults; pulse pressure decreased slightly with age in children (r=-.10, P=.06) and increased in adults (r=.29, P<.0001). As a consequence, SV/PP ratio increased with age in children (r=.51, P<.0001) and decreased in adults (r=-.18, P=.0004). To control for changes in body size that influence the size of the arterial tree, we used ANCOVA to adjust SV/PP for body size. Body size–adjusted SV/PP ratio was no longer related to age in children, whereas the negative relation with aging in adults remained statistically significant (r=-.19, P<.0002). Heart rate was negatively related to SV/PP ratio in both children and adolescents and adults, but this relation did not influence the relation with age. In multivariate analysis, high SV/PP ratio was predicted by greater height (P<.002) and weight (P<.04) and nonwhite race (P<.001) in children and adolescents and by younger age (P<.0001), greater weight (P<.0001), and low heart rate (P<.001) in adults. Sex did not enter the regression models. Thus, (1) SV/PP ratio is a measure of increasing capacity of the arterial tree during growth, whereas it depends on arterial compliance during adulthood through old age; (2) arterial compliance decreases progressively with aging; (3) the apparent difference between males and females might be due to their different body sizes.
Key Words: age • compliance • body constitution • sex • stroke volume
This article has been cited by other articles:
 |
|
 |
|
  J. S. Drukteinis, M. J. Roman, R. R. Fabsitz, E. T. Lee, L. G. Best, M. Russell, and R. B. Devereux Cardiac and Systemic Hemodynamic Characteristics of Hypertension and Prehypertension in Adolescents and Young Adults: The Strong Heart Study Circulation, January 16, 2007; 115(2): 221 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mahapatra, R. A. Nishimura, P. Sorajja, S. Cha, and M. D. McGoon Relationship of Pulmonary Arterial Capacitance and Mortality in Idiopathic Pulmonary Arterial Hypertension J. Am. Coll. Cardiol., February 21, 2006; 47(4): 799 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. de Simone, P. Verdecchia, S. Pede, M. Gorini, and A. P. Maggioni Prognosis of Inappropriate Left Ventricular Mass in Hypertension: The MAVI Study Hypertension, October 1, 2002; 40(4): 470 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Baldassarre, M. Amato, C. Palombo, C. Morizzo, L. Pustina, and C. R. Sirtori Time course of forearm arterial compliance changes during reactive hyperemia Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1093 - H1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Devereux, J. N. Bella, V. Palmieri, A. Oberman, D. W. Kitzman, P. N. Hopkins, D.C. Rao, D. Morgan, M. Paranicas, D. Fishman, et al. Left Ventricular Systolic Dysfunction in a Biracial Sample of Hypertensive Adults: The HyperGEN Study Hypertension, September 1, 2001; 38(3): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Henriksen, S Moller, S Schifter, J Abrahamsen, and U Becker High arterial compliance in cirrhosis is related to low adrenaline and elevated circulating calcitonin gene related peptide but not to activated vasoconstrictor systems Gut, July 1, 2001; 49(1): 112 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Henriksen, S. Fuglsang, F. Bendtsen, E. Christensen, and S. Moller Arterial compliance in patients with cirrhosis: stroke volume-pulse pressure ratio as simplified index Am J Physiol Gastrointest Liver Physiol, April 1, 2001; 280(4): G584 - G594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S Hayward, W. V Kalnins, and R. P Kelly Gender-related differences in left ventricular chamber function Cardiovasc Res, February 1, 2001; 49(2): 340 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Weber, J. M. Neutel, and D. H. G. Smith Contrasting clinical properties and exercise responses in obese and lean hypertensive patients J. Am. Coll. Cardiol., January 1, 2001; 37(1): 169 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Devereux, M. J. Roman, M. Paranicas, M. J. O'Grady, E. T. Lee, T. K. Welty, R. R. Fabsitz, D. Robbins, E. R. Rhoades, and B. V. Howard Impact of Diabetes on Cardiac Structure and Function : The Strong Heart Study Circulation, May 16, 2000; 101(19): 2271 - 2276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M Montgomery, L. R Berney, and D. Blane Prepubertal stature and blood pressure in early old age Arch. Dis. Child., May 1, 2000; 82(5): 358 - 363. [Abstract] [Full Text]
|
|
|
|
|
|
C. S. Hayward, R. P. Kelly, and P. Collins The roles of gender, the menopause and hormone replacement on cardiovascular function Cardiovasc Res, April 1, 2000; 46(1): 28 - 49. [Full Text] [PDF]
|
|
|
|
|
|
J. Alfie, G. D. Waisman, C. R. Galarza, and M. I. Camera Contribution of Stroke Volume to the Change in Pulse Pressure Pattern With Age Hypertension, October 1, 1999; 34(4): 808 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Bella, M. J. Roman, R. Pini, J. E. Schwartz, T. G. Pickering, and R. B. Devereux Assessment of Arterial Compliance by Carotid Midwall Strain-Stress Relation in Normotensive Adults Hypertension, March 1, 1999; 33(3): 787 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Bella, M. J. Roman, R. Pini, J. E. Schwartz, T. G. Pickering, and R. B. Devereux Assessment of Arterial Compliance by Carotid Midwall Strain-Stress Relation in Hypertension Hypertension, March 1, 1999; 33(3): 793 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. de Simone, M. J. Roman, M. J. Koren, G. A. Mensah, A. Ganau, and R. B. Devereux Stroke Volume/Pulse Pressure Ratio and Cardiovascular Risk in Arterial Hypertension Hypertension, March 1, 1999; 33(3): 800 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. de Simone, R. B. Devereux, T. R. Kimball, G. F. Mureddu, M. J. Roman, F. Contaldo, and S. R. Daniels Interaction Between Body Size and Cardiac Workload : Influence on Left Ventricular Mass During Body Growth and Adulthood Hypertension, May 1, 1998; 31(5): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|