This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stein, C. M. Articles by Wood, A. J. J. Search for Related Content PubMed PubMed Citation Articles by Stein, C. M. Articles by Wood, A. J. J. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB PHENYLEPHRINE

(Hypertension. 1997;29:1273-1277.)
© 1997 American Heart Association, Inc.

Articles

Lack of Correlation Between Arterial and Venous ß-Adrenergic Receptor Sensitivity

C. Michael Stein; Robert Deegan; ; Alastair J. J. Wood

From the Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn.

Correspondence to Dr Alastair J.J. Wood, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Medical Research Building Rm 546, Nashville, TN 37232-6602.

Abstract The regulation of vascular ß-adrenoceptor responses in humans has been studied in vivo in both arteries and veins. Because venous responses can be studied less invasively than arterial responses, they are an attractive substitute for the measurement of arterial responses, provided that venous responses are representative of responses in resistance arteries. However, although venous, particularly hand vein response, has been extensively studied, arterial and venous ß-adrenergic sensitivities, in the same individuals, have not been compared. Measures of venous and arterial ß-adrenergic sensitivities were compared in 10 healthy normotensive subjects. Forearm blood flow, after administration of increasing doses of isoproterenol into the brachial artery, was measured by strain-gauge plethysmography and was used for determination of arterial ß-adrenoceptor sensitivity, expressed as the IP₅₀₀ (the dose of isoproterenol resulting in a fivefold [500%] increase in baseline forearm blood flow). Venous sensitivity to isoproterenol, expressed as the IP₁₅ (the dose of isoproterenol resulting in 15% venodilation), was measured in a dorsal hand vein using the linear variable differential transformer. Administration of isoproterenol into the hand vein and brachial artery resulted in venodilation and increased forearm blood flow, respectively. However, there was no correlation between the measures of venous (log IP₁₅) and arterial (log IP₅₀₀) measures of vascular ß-adrenergic sensitivity (r=-.12, P=.74). We conclude that since arterial and venous sensitivities to isoproterenol in healthy white men did not correlate, venous and arterial ß-adrenergic responses are regulated differently and that studies examining vascular ß-adrenoceptor sensitivity would most appropriately be performed in a vessel representative of the vascular bed of interest.

Key Words: veins • arteries • vasodilation • isoproterenol

This article has been cited by other articles:

				M. M. Fung, C. Nguyen, P. Mehtani, R. M. Salem, B. Perez, B. Thomas, M. Das, N. J. Schork, S. K. Mahata, M. G. Ziegler, et al. Genetic Variation Within Adrenergic Pathways Determines In Vivo Effects of Presynaptic Stimulation in Humans Circulation, January 29, 2008; 117(4): 517 - 525. [Abstract] [Full Text] [PDF]

				R. Landau, V. Dishy, A. J.J. Wood, C. M. Stein, and R. M. Smiley Disproportionate Decrease in {alpha}- Compared With {beta}-Adrenergic Sensitivity in the Dorsal Hand Vein in Pregnancy Favors Vasodilation Circulation, August 27, 2002; 106(9): 1116 - 1120. [Abstract] [Full Text] [PDF]

				C. M. Stein, C. C. Lang, I. Singh, H. B. He, and A. J. J. Wood Increased Vascular Adrenergic Vasoconstriction and Decreased Vasodilation in Blacks : Additive Mechanisms Leading to Enhanced Vascular Reactivity Hypertension, December 1, 2000; 36(6): 945 - 951. [Abstract] [Full Text] [PDF]

				B. J. Kneale, P. J. Chowienczyk, S. E. Brett, D. J. Coltart, and J. M. Ritter Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1233 - 1238. [Abstract] [Full Text] [PDF]

				J. R. Cockcroft, A. G. Gazis, D. J. Cross, A. Wheatley, J. Dewar, I. P. Hall, and J. P. Noon {beta}2-Adrenoceptor Polymorphism Determines Vascular Reactivity in Humans Hypertension, September 1, 2000; 36(3): 371 - 375. [Abstract] [Full Text] [PDF]