Hypertension, Vol 3, 18-22, Copyright © 1981 by American Heart Association
OA Carretero, S Miyazaki and AG Scicli
The role of kinins in the acute antihypertensive effect of a converting
enzyme inhibitor (CEI) was studied in sodium-depleted normotensive and in
two-kidney, one clip chronically hypertensive rats (2K-1C). The 2K- 1C were
on a normal sodium diet. The acute vasodepressor effect of the CEI was
determined in these two groups either after administration of normal rabbit
globulins or antikinin globulins. The amount of kinin antibodies
administered completely blocked the hypotensive effects of bradykinin, 400
ng/kg, and urinary kallikrein, 4 microgram/kg. After administration of CEI
in the sodium-depleted rats there was no significant difference (p greater
than 0.05) in the acute changes in mean blood pressure (BP) between the
group pretreated with normal rabbit globulins (delta BP -32.3 +/- 3.9 mm
Hg) and the group pretreated with antikinin globulins (delta BP -25 +/- 2.5
mm Hg). In the 2K-1C pretreated with normal rabbit globulins, the CEI
produced a decrease in BP of -21 +/- 4.5 mm Hg. This decrease was almost
completely blocked in the group pretreated with the antikinin globulins
(delta BP -4 +/- 4.1 mm Hg). These differences in the changes in BP were
significant (p less than 0.02). These results suggest that the acute
antihypertensive effect of the CEI in the sodium-depleted rats is probably
due to inhibition of the conversion of angiotensin I to II while in the
2K-1C it is due, in part, to an increase in kinin concentrations secondary
to the inhibition of kininase II.
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