Hypertension, Vol 3, 48-52, Copyright © 1981 by American Heart Association
DS Goldstein
Of 32 studies comparing plasma norepinephrine concentrations in
hypertensive and normotensive groups, 28 (88%) reported higher levels in
the hypertensive group. However, only 13 (41%) of the studies reported
statistically significant hypertensive-normotensive differences in
norepinephrine, leading the present attempt to identify factors
differentiating "positive" studies (those reporting significant
hypertensive-normotensive differences) from "negative" studies (those
reporting nonsignificant differences). Hypertensive norepinephrine levels
were similar in positive and negative studies (281 vs 288 pg/ml), but
normotensive levels were lower in the positive studies (177 vs 269 pg/ml).
When compared with the fluorimetric technique, the radioenzymatic type of
assay was associated both with a lower frequency of positive results (25%
vs 100%) and greater intrastudy standard deviations (152 vs 72 pg/ml).
Hypertensive-normotensive differences varied inversely with age (r =
-0.37). Resolution of the persisting controversy about norepinephrine
levels in essential hypertension will require more attention to the causes
of variability associated with the assay technique, to the sources,
characteristics, and treatment of the normotensive controls, and to the age
of the patient population.
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