This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Haywood, J. R. Articles by Hinojosa-Laborde, C. Search for Related Content PubMed PubMed Citation Articles by Haywood, J. R. Articles by Hinojosa-Laborde, C. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Dietary Sodium High Blood Pressure

(Hypertension. 1997;30:667.)
© 1997 American Heart Association, Inc.

Articles

Sexual Dimorphism of Sodium-Sensitive Renal-Wrap Hypertension

Joseph R. Haywood; Carmen Hinojosa-Laborde

From the Departments of Pharmacology and Physiology, University of Texas Health Science Center, San Antonio.

Correspondence to Joseph R. Haywood, PhD, UTHSCSA-Pharmacology, 7703 Floyd Curl Dr, San Antonio, TX 78284-7764. E-mail haywood{at}uthscsa.edu

Abstract One-kidney, figure-8 renal wrap or sham operation was performed on male and female rats to determine if a difference existed in the expression of hypertension between the sexes. Animals were prepared with radiotelemetry transmitters to monitor mean arterial pressure and heart rate continuously throughout an 8-week study. Dietary sodium content was changed during the post–renal-wrap period from normal (100 µmol/g chow) to high (2000 µmol/g chow) to low (<2 µmol/g chow) to assess sodium sensitivity. Both male and female rats experienced an increase in arterial pressure after the renal-wrap procedure; however, the hypertension was significantly attenuated in the females. High salt caused a further increase in both groups of rats that was again attenuated in the female rats. Low sodium diet reduced arterial pressure in all groups of rats. Heart rate was significantly elevated in the female rats during all dietary interventions. The data were fit to a cosine function to analyze circadian rhythm changes. An increase in the light/dark difference for arterial pressure in the hypertensive rats during high salt diet resulted in an increase in the circadian amplitude (range of the rhythm). In the normotensive rats fed a high salt diet, the arterial pressure acrophase (peak of rhythm) was delayed while the heart rate acrophase was shifted to an earlier time. These studies showed that female rats are protected against one-kidney, figure-8 renal-wrap hypertension and are less sensitive to the effects of sodium.

Key Words: circadian rhythm • blood pressure • heart rate • hypertension, one kidney, figure-8 renal wrap • sex differences • hypertension, sodium-dependent

This article has been cited by other articles:

				B. Xue, J. Pamidimukkala, D. B. Lubahn, and M. Hay Estrogen receptor-{alpha} mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1770 - H1776. [Abstract] [Full Text] [PDF]

				B. Xue, J. Pamidimukkala, and M. Hay Sex differences in the development of angiotensin II-induced hypertension in conscious mice Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2177 - H2184. [Abstract] [Full Text] [PDF]

				J. Pamidimukkala, B. Xue, L. G. Newton, D. B. Lubahn, and M. Hay Estrogen receptor-{alpha} mediates estrogen facilitation of baroreflex heart rate responses in conscious mice Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1063 - H1070. [Abstract] [Full Text] [PDF]

				H. Ji, C. Pesce, W. Zheng, J. Kim, Y. Zhang, S. Menini, J. R. Haywood, and K. Sandberg Sex differences in renal injury and nitric oxide production in renal wrap hypertension Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H43 - H47. [Abstract] [Full Text] [PDF]

				M. P. Printz Radiotelemetry comes of age--perhaps just in time Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2004; 286(5): R818 - R819. [Full Text] [PDF]

				O. Baltatu, C. Cayla, R. Iliescu, D. Andreev, and M. Bader Abolition of End-Organ Damage by Antiandrogen Treatment in Female Hypertensive Transgenic Rats Hypertension, March 1, 2003; 41(3): 830 - 833. [Abstract] [Full Text] [PDF]

				O. Baltatu, C. Cayla, R. Iliescu, D. Andreev, C. Jordan, and M. Bader Abolition of Hypertension-Induced End-Organ Damage by Androgen Receptor Blockade in Transgenic Rats Harboring the Mouse Ren-2 Gene J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2681 - 2687. [Abstract] [Full Text] [PDF]

				L. P. Audoly, S. L. Tilley, J. Goulet, M. Key, M. Nguyen, J. L. Stock, J. D. McNeish, B. H. Koller, and T. M. Coffman Identification of specific EP receptors responsible for the hemodynamic effects of PGE2 Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H924 - H930. [Abstract] [Full Text] [PDF]

				D. L. Lange, J. R. Haywood, and C. Hinojosa-Laborde Role of the Adrenal Medullae in Male and Female DOCA-Salt Hypertensive Rats Hypertension, January 1, 1998; 31(1): 403 - 408. [Abstract] [Full Text] [PDF]