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(Hypertension. 1998;31:114.)
© 1998 American Heart Association, Inc.

Scientific Contributions

Insulin Resistance and Hypertension in Non-obese Africans in Tanzania

Yasin M. Mgonda; Kaushik L. Ramaiya; Andrew B. M. Swai; Donald G. McLarty¹; K. George M. M. Alberti

From the Muhimbili University College of Health Sciences (Y.M.M., K.L.R., A.B.M.S., D.G.M), University of Dar es Salaam, Tanzania; Shree Hindu Mandal Hospital (K.L.R.), Dar es Salaam, Tanzania; and Department of Medicine (K.G.M.M.A.), University of Newcastle on Tyne, UK.

Correspondence to Professor K.G.M.M. Alberti, Department of Medicine, The Medical School, Framlington Place, Newcastle on Tyne, NE2 4HH, UK. E-mail george.alberti{at}ncl.ac.uk

Abstract—Insulin sensitivity was assessed using a glucose-insulin infusion test in 15 newly diagnosed non-obese hypertensive black Tanzanians with normal glucose tolerance and in 15 normotensive control subjects matched for age, sex, and body mass index. The steady-state blood glucose and metabolic clearance rate of glucose (MCR) were used as measures of insulin sensitivity. The mean MCR (glucose) was significantly reduced (7.12±0.57 versus 9.50±0.69 µmol/kg per minute; P<.05) and mean steady-state blood glucose was significantly elevated (5.0±0.3 versus 3.7±0.3 mmol/L; P<.01) in subjects with hypertension compared with the normotensive group. For all subjects there was a significant inverse correlation between MCR (glucose) and systolic (P=.003) and diastolic (P=.005) blood pressure; and a positive correlation was found between fasting serum insulin levels and systolic (P=.005) and diastolic (P=.004) blood pressure. These observations were independent of body mass index and serum lipid levels. These data indicate a strong association between insulin mediated glucose uptake and blood pressure in this population of normal weight untreated urban Africans.

Key Words: insulin resistance • Africans • blood pressure

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