From the Department of Pathology, University of Washington (Seattle).
Correspondence to E.J. Su, Department of Pathology, Box 357335, Seattle WA 98195. E-mail enmingsu{at}u.washington.edu
Abstract—The purpose of this
investigation was to evaluate the role of blood pressure in the
proliferative response of vascular smooth muscle cells to systemic
infusion of angiotensin II (Ang II). Our laboratory has
previously shown that infusion of Ang II induces smooth muscle cell
proliferation in rat mesenteric vessels and carotid arteries. Ang II, a
strong vasopressor, raised systolic blood pressure in rats from
120 to 200 mm Hg at a dose of 435 ng ·
kg-1 · min-1 after 1 week of
treatment. The question arises as to whether this development of
hypertension is a primary contributor to the replicative activities
observed in the arterial wall of the mesenteric arteries or
the carotid arteries or whether Ang II alone, without an increase in
blood pressure, is sufficient to stimulate proliferation in these
vessels. In the previous studies, we found that Ang II stimulated
smooth muscle cell replication in the carotid artery and in type III
and type I mesenteric microvessels. This study demonstrates that
although administration of hydralazine normalizes the animals'
blood pressures, it does not suppress the mitogenic effect
of Ang II. Thus, it appears that Ang II has a direct effect on
cell proliferation.
© 1998 American Heart Association, Inc.
Scientific Contributions
Angiotensin II Induces Vascular Smooth Muscle Cell Replication Independent of Blood Pressure
Key Words: angiotensin II • hyperplasia • hypertrophy • muscle, smooth • mesenteric arteries • proliferation
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