From the Institute for Cardiovascular Studies, College of Pharmacy,
University of Houston (Texas).
Abstract—Dopamine plays an important
role in the regulation of renal sodium excretion. The synthesis of
dopamine and the presence of dopamine receptor subtypes
(D1A, D1B as D1-like and
D2, and D3 as D2-like) have been
shown within the kidney. The activation of D1-like
receptors located on the proximal tubules causes inhibition of tubular
sodium reabsorption by inhibiting Na,H-exchanger and Na,K-ATPase
activity. The D1-like receptors are linked to the multiple
cellular signaling systems (namely, adenylyl cyclase, phospholipase C,
and phospholipase A2) in the different regions of the
nephron. Defective renal dopamine production and/or dopamine
receptor function have been reported in human primary hypertension as
well as in genetic models of animal hypertension. There may be a
primary defect in D1-like receptors and an altered
signaling system in the proximal tubules that lead to reduced
dopamine-mediated effects on renal sodium excretion in hypertension.
Recently, it has been shown in animal models that the disruption of
either D1A or D3 receptors at the gene level
causes hypertension in mice. Dopamine and dopamine receptor agonists
also provide therapeutic potential in treatment of various
cardiovascular pathological conditions, including
hypertension. However, because of the poor bioavailability of the
currently available compounds, the use of D1-like agonists
is limited to the management of patients with severe hypertension when
a rapid reduction of blood pressure is clinically indicated and in
acute management of patients with heart failure. In conclusion, there
is convincing evidence that dopamine and dopamine receptors play an
important role in regulation of renal function, suggesting that a
defective dopamine receptor/signaling system may contribute to the
development and maintenance of hypertension. Further studies
need to be directed toward establishing a direct correlation between
defective dopamine receptor gene in the kidney and development of
hypertension. Subsequently, it may be possible to use a therapeutic
approach to correct the defect in dopamine receptor gene causing
the hypertension.
© 1998 American Heart Association, Inc.
Review
Renal Dopamine Receptor Function in Hypertension
Key Words: dopamine • receptors, dopamine • kidney tubules, proximal • kidney • hypertension, renal
This article has been cited by other articles:
 |
|
 |
|
  A. R. Cinelli, R. Efendiev, and C. H. Pedemonte Trafficking of Na-K-ATPase and dopamine receptor molecules induced by changes in intracellular sodium concentration of renal epithelial cells Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1117 - F1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Doris Promoting Regulatory Gene Variation in Sodium Reabsorption Hypertension, October 1, 2008; 52(4): 623 - 624. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Efendiev, C. E. Budu, A. M. Bertorello, and C. H. Pedemonte G-protein-coupled Receptor-mediated Traffic of Na,K-ATPase to the Plasma Membrane Requires the Binding of Adaptor Protein 1 to a Tyr-255-based Sequence in the {alpha}-Subunit J. Biol. Chem., June 20, 2008; 283(25): 17561 - 17567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Gildea, X. Wang, P. A. Jose, and R. A. Felder Differential D1 and D5 Receptor Regulation and Degradation of the Angiotensin Type 1 Receptor Hypertension, February 1, 2008; 51(2): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Vellaichamy, D. Zhao, N. Somanna, and K. N. Pandey Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy Physiol Genomics, October 19, 2007; 31(2): 193 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday and M. F. Lokhandwala Oxidative stress reduces renal dopamine D1 receptor-Gq/11{alpha} G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2 Am J Physiol Renal Physiol, July 1, 2007; 293(1): F306 - F315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maurel, O. Spreux-Varoquaux, F. Amenta, S. K. Tayebati, D. Tomassoni, M.-H. Seguelas, A. Parini, and N. Pizzinat Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1592 - F1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Pinho, M. P. Serrao, and P. Soares-da-Silva High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1452 - F1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Z. Fardoun, M. Asghar, and M. Lokhandwala Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats Am J Physiol Renal Physiol, November 1, 2006; 291(5): F945 - F951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zeng, Y. Liu, Z. Wang, D. He, L. Huang, P. Yu, S. Zheng, J. E. Jones, L. D. Asico, U. Hopfer, et al. Activation of D3 Dopamine Receptor Decreases Angiotensin II Type 1 Receptor Expression in Rat Renal Proximal Tubule Cells Circ. Res., September 1, 2006; 99(5): 494 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marwaha and M. F. Lokhandwala Tempol reduces oxidative stress and restores renal dopamine D1-like receptor- G protein coupling and function in hyperglycemic rats Am J Physiol Renal Physiol, July 1, 2006; 291(1): F58 - F66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sanada, J. Yatabe, S. Midorikawa, T. Katoh, S. Hashimoto, T. Watanabe, J. Xu, Y. Luo, X. Wang, C. Zeng, et al. Amelioration of Genetic Hypertension by Suppression of Renal G Protein-Coupled Receptor Kinase Type 4 Expression Hypertension, June 1, 2006; 47(6): 1131 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, Z. Wang, H. Li, P. Yu, S. Zheng, L. Wu, L. D. Asico, U. Hopfer, G. M. Eisner, R. A. Felder, et al. D3 Dopamine Receptor Directly Interacts With D1 Dopamine Receptor in Immortalized Renal Proximal Tubule Cells Hypertension, March 1, 2006; 47(3): 573 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Bek, X. Wang, L. D. Asico, J. E. Jones, S. Zheng, X. Li, G. M. Eisner, D. K. Grandy, R. M. Carey, P. Soares-da-Silva, et al. Angiotensin-II Type 1 Receptor-Mediated Hypertension in D4 Dopamine Receptor-Deficient Mice Hypertension, February 1, 2006; 47(2): 288 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Efendiev and C. H. Pedemonte Contrary to Rat-Type, Human-Type Na,K-ATPase Is Phosphorylated at the Same Amino Acid by Hormones that Produce Opposite Effects on Enzyme Activity J. Am. Soc. Nephrol., January 1, 2006; 17(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, Z. Wang, U. Hopfer, L. D. Asico, G. M. Eisner, R. A. Felder, and P. A. Jose Rat Strain Effects of AT1 Receptor Activation on D1 Dopamine Receptors in Immortalized Renal Proximal Tubule Cells Hypertension, October 1, 2005; 46(4): 799 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, Z. Yang, Z. Wang, J. Jones, X. Wang, J. Altea, A. J. Mangrum, U. Hopfer, D. R. Sibley, G. M. Eisner, et al. Interaction of Angiotensin II Type 1 and D5 Dopamine Receptors in Renal Proximal Tubule Cells Hypertension, April 1, 2005; 45(4): 804 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Hakam and T. Hussain Renal Angiotensin II Type-2 Receptors Are Upregulated and Mediate the Candesartan-Induced Natriuresis/Diuresis in Obese Zucker Rats Hypertension, February 1, 2005; 45(2): 270 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, L. D. Asico, P. Yu, Z. Wang, J. E. Jones, R.-k. Bai, D. R. Sibley, R. A. Felder, and P. A. Jose D5 dopamine receptor regulation of phospholipase D Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H55 - H61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, H. Sanada, H. Watanabe, G. M. Eisner, R. A. Felder, and P. A. Jose Functional genomics of the dopaminergic system in hypertension Physiol Genomics, November 17, 2004; 19(3): 233 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday, T. Hussain, and M. F. Lokhandwala Renal dopamine D1 receptor dysfunction is acquired and not inherited in obese Zucker rats Am J Physiol Renal Physiol, July 1, 2004; 287(1): F109 - F116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, D. Wang, L. D. Asico, W. J. Welch, C. S. Wilcox, U. Hopfer, G. M. Eisner, R. A. Felder, and P. A. Jose Aberrant D1 and D3 Dopamine Receptor Transregulation in Hypertension Hypertension, March 1, 2004; 43(3): 654 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, D. Wang, Z. Yang, Z. Wang, L. D. Asico, C. S. Wilcox, G. M. Eisner, W. J. Welch, R. A. Felder, and P. A. Jose Dopamine D1 Receptor Augmentation of D3 Receptor Action in Rat Aortic or Mesenteric Vascular Smooth Muscles Hypertension, March 1, 2004; 43(3): 673 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Asghar, T. Hussain, and M. F. Lokhandwala Overexpression of PKC-{beta}I and -{delta} contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1100 - F1107. [Abstract] [Full Text]
|
|
|
|
|
|
C. Zeng, Y. Luo, L. D. Asico, U. Hopfer, G. M. Eisner, R. A. Felder, and P. A. Jose Perturbation of D1 Dopamine and AT1 Receptor Interaction in Spontaneously Hypertensive Rats Hypertension, October 1, 2003; 42(4): 787 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Pinho, P. Gomes, M. P. Serrao, M. J. Bonifacio, and P. Soares-da-Silva Organ-Specific Overexpression of Renal LAT2 and Enhanced Tubular L-DOPA Uptake Precede the Onset of Hypertension Hypertension, October 1, 2003; 42(4): 613 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Efendiev, C. E. Budu, A. R. Cinelli, A. M. Bertorello, and C. H. Pedemonte Intracellular Na+ Regulates Dopamine and Angiotensin II Receptors Availability at the Plasma Membrane and Their Cellular Responses in Renal Epithelia J. Biol. Chem., August 1, 2003; 278(31): 28719 - 28726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Banday, M. Asghar, T. Hussain, and M. F. Lokhandwala Dopamine-Mediated Inhibition of Renal Na,K-ATPase Is Reduced by Insulin Hypertension, June 1, 2003; 41(6): 1353 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zheng, P. Yu, C. Zeng, Z. Wang, Z. Yang, P. M. Andrews, R. A. Felder, and P. A. Jose G{alpha}12- and G{alpha}13-Protein Subunit Linkage of D5 Dopamine Receptors in the Nephron Hypertension, March 1, 2003; 41(3): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zeng, L. D. Asico, X. Wang, U. Hopfer, G. M. Eisner, R. A. Felder, and P. A. Jose Angiotensin II Regulation of AT1 and D3 Dopamine Receptors in Renal Proximal Tubule Cells of SHR Hypertension, March 1, 2003; 41(3): 724 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Narkar, T. Hussain, and M. F. Lokhandwala Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1290 - F1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Umrani, A. A. Banday, T. Hussain, and M. F. Lokhandwala Rosiglitazone Treatment Restores Renal Dopamine Receptor Function in Obese Zucker Rats Hypertension, December 1, 2002; 40(6): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Asghar, T. Hussain, and M. F. Lokhandwala Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats Am J Physiol Renal Physiol, August 1, 2002; 283(2): F350 - F355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Efendiev, A. M. Bertorello, R. Zandomeni, A. R. Cinelli, and C. H. Pedemonte Agonist-dependent Regulation of Renal Na+,K+-ATPase Activity Is Modulated by Intracellular Sodium Concentration J. Biol. Chem., March 22, 2002; 277(13): 11489 - 11496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. LUIPPOLD, C. ZIMMERMANN, M. MAI, D. KLOOR, D. STARCK, G. GROSS, and B. MUHLBAUER Dopamine D3 Receptors and Salt-Dependent Hypertension J. Am. Soc. Nephrol., November 1, 2001; 12(11): 2272 - 2279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. NARKAR, T. HUSSAIN, C. PEDEMONTE, and M. F. LOKHANDWALA Dopamine D2 Receptor Activation Causes Mitogenesis via p44/42 Mitogen-Activated Protein Kinase in Opossum Kidney Cells J. Am. Soc. Nephrol., September 1, 2001; 12(9): 1844 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. X. Li, M. Bek, L. D. Asico, Z. Yang, D. K. Grandy, D. S. Goldstein, M. Rubinstein, G. M. Eisner, and P. A. Jose Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice Hypertension, September 1, 2001; 38(3): 303 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gomes, M. A. Vieira-Coelho, and P. Soares-da-Silva Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na+/H+ exchanger Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R10 - R18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. ASGHAR, V. KANSRA, T. HUSSAIN, and M. F. LOKHANDWALA Hyperphosphorylation of Na-Pump Contributes to Defective Renal Dopamine Response in Old Rats J. Am. Soc. Nephrol., February 1, 2001; 12(2): 226 - 232. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Feraille and A. Doucet Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control Physiol Rev, January 1, 2001; 81(1): 345 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Therien and R. Blostein Mechanisms of sodium pump regulation Am J Physiol Cell Physiol, September 1, 2000; 279(3): C541 - C566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Thomas, B. Tomlinson, and J. A. J. H. Critchley Modulation of Blood Pressure and Obesity With the Dopamine D2 Receptor Gene TaqI Polymorphism Hypertension, August 1, 2000; 36(2): 177 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sato, M. Soma, T. Nakayama, and K. Kanmatsuse Dopamine D1 Receptor Gene Polymorphism Is Associated With Essential Hypertension Hypertension, August 1, 2000; 36(2): 183 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Lucas-Teixeira, M. A. Vieira-Coelho, and P. Soares-da-Silva Food Intake Abolishes the Response of Rat Jejunal Na+,K+-ATPase to Dopamine J. Nutr., April 1, 2000; 130(4): 877 - 881. [Abstract] [Full Text]
|
|
|
|
|
|
L. J. Millatt and H. M. Siragy Age-Related Changes in Renal Cyclic Nucleotides and Eicosanoids in Response to Sodium Intake Hypertension, February 1, 2000; 35(2): 643 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, C. K. Hwang, E. Junn, G. Lee, and M. M. Mouradian ZIC2 and Sp3 Repress Sp1-induced Activation of the Human D1ADopamine Receptor Gene J. Biol. Chem., December 1, 2000; 275(49): 38863 - 38869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Narkar, T. Hussain, and M. Lokhandwala Role of tyrosine kinase and p44/42 MAPK in D2-like receptor-mediated stimulation of Na+, K+-ATPase in kidney Am J Physiol Renal Physiol, April 1, 2002; 282(4): F697 - F702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gomes and P. Soares-da-Silva Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na+-K+-ATPase activity Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1084 - F1096. [Abstract] [Full Text] [PDF]
|
|