From the Department of Medicine, Division of Cardiology, Emory University
School of Medicine, Atlanta, Ga.
Correspondence to Kathy K. Griendling, PhD, Emory University School of Medicine, Division of Cardiology, 1639 Pierce Dr, 319 WMB, Atlanta, GA 30322. E-mail kgriend{at}emory.edu
Abstract—Caveolae are membrane
domains that have been implicated in signal transduction, and caveolins
are major structural components of these domains. We found that all
reported caveolin isoforms (caveolin-1, -2, and -3) were expressed in
vascular smooth muscle cells (VSMCs); however, only caveolin-1 mRNA was
regulated by angiotensin II (Ang II). Ang II (100 nmol/L)
increased caveolin-1 mRNA, with a peak at 2 hours (193±6% of control,
P<0.01, n=4). In contrast, Ang II significantly
decreased caveolin-1 protein, with a nadir at 4 hours (64±5% of
control, P<0.01, n=6). [35S]Methionine
labeling showed that Ang II increased caveolin biosynthesis (226±33%
of control labeling at 4 hours), suggesting that the transient decrease
in caveolin protein levels is due to increased degradation. When cells
were fractionated with sucrose, on agonist stimulation, AT1
receptors appeared in fraction 5 where caveolin was fractionated. This
migration was blocked by low temperature and treatment with
phenylarsine oxide, interventions that interfere with agonist-induced
Ang II type 1 (AT1) receptor sequestration and tonic phase
signaling. In addition, caveolin-1 coimmunoprecipitates with
AT1 receptor only on agonist stimulation. These data
support the concept that the caveola is a specialized signaling domain
in VSMCs that can be dynamically accessed by the AT1
receptor. Because of the signaling and coupling proteins that are
localized in caveolae and because of evidence that these proteins may
interact directly with caveolin, caveola–AT1 receptor
interaction likely represents an important focus for dynamic
control of receptor signaling in VSMCs.
© 1998 American Heart Association, Inc.
Scientific Contributions
Angiotensin II Type 1 Receptor
Relationship With Caveolae and Caveolin After Initial Agonist Stimulation
Key Words: angiotensin II • signal transduction • receptors, angiotensin
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|
|
|
|
|
|
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|
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|
|
|
|
|
|
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 |
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