From Fukuoka University, School of Medicine, Department of Internal
Medicine, Fukuoka City, Japan.
Correspondence to Hidenori Urata, MD, Fukuoka University, School of Medicine, Department of Internal Medicine, 7–45-1 Nanakuma, Jonan-ku, Fukuoka 814–0180, Japan. E-mail uratah{at}msat.fukuoka-u.ac.jp
Abstract—Angiotensin
(Ang) II plays an important role in cardiovascular
homeostasis, not only in the systemic circulation but also at the
tissue level, and is involved in the remodeling of the heart and
vasculature under pathological conditions. Although alternative Ang
II–forming pathways are known to exist in various tissues, the details
of such pathways remain unclear. The aim of this study was to examine
tissue Ang II–forming activities and to identify the responsible
enzyme in several organs (lung, heart, and aorta) in various species
(human, hamster, rat, rabbit, dog, pig, and marmoset). Among the organs
examined, the lung contained the highest Ang II–forming activity. The
responsible enzyme for pulmonary Ang II formation was
angiotensin I-converting enzyme (ACE) in all of the species
except the human lung, in which a chymaselike enzyme was dominant. In
the heart, the highest total Ang II–forming activity was observed in
humans, and a chymaselike enzyme was dominant in all of the species
except rabbit and pig. Aorta exhibited a relatively high total Ang
II–forming activity, with a predominance of chymaselike activity in
all of the species except rabbit and pig, in which ACE was dominant.
Our results indicate that there were remarkable differences in Ang
II–forming pathways among the species and organs we examined. To study
the pathophysiological roles of ACE-independent Ang
II formation, one should choose species and/or organs that have Ang
II–forming pathways similar to those in humans.
© 1998 American Heart Association, Inc.
Scientific Contributions
Differences in Tissue Angiotensin II–Forming Pathways by Species and Organs In Vitro
Key Words: angiotensin-converting enzyme • chymase • kallikrein • heart • lung • aorta
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