From the Department of Imaging, Imperial College, National Heart and Lung
Institute, Royal Brompton Hospital (E.D.L.); the Academic Department of
Radiology, St. Bartholomew's Hospital (E.D.L.); the Centre for Diabetes
and Cardiovascular Risk, Division of Medicine, University College London
Medical School (K.D.H., A.R., S.W.C.); and the School of Applied Sciences,
University of the South Bank (R.C.T., K.K., R.G.G.), London, UK.
Correspondence to Dr E.D. Lehmann, Department of Imaging, National Heart and Lung Institute, Royal Brompton Hospital, Sydney St, London SW3 6NP, UK. E-mail aida{at}globalnet.co.uk
Abstract
Abstract—The aim of this study
was to establish the relation between noninvasive Doppler
ultrasound assessments of aortic compliance, based on
"foot-to-foot" aortic pulse wave velocity measurements, and
presumed atherosclerotic load in patients with vascular disease and/or
diabetes mellitus. One hundred ten patients with vascular disease
and/or diabetes mellitus (arteriopaths) underwent measurement of in
vivo aortic compliance using Doppler ultrasound. Demographic data
on these subjects were recorded along with details of
cardiovascular risk factors and events. Aortic
compliance values were compared with data from 51 age-matched healthy,
asymptomatic subjects putatively free of vascular disease
(controls). Data are expressed as mean±SD. Arteriopaths were aged
64.1±8.4 years and had total cholesterol levels of
5.9±1.1 mmol/L and aortic compliance of 0.78±0.42%/10
mm Hg [1.33 kPa]. Most arteriopaths had 2 or more
cardiovascular risk factors and events: diabetes
(n=41), hypertension (n=45), smoking (n=86), cerebrovascular/transient
ischemic event (n=13), myocardial infarction (n=44), angina
(n=51), and/or peripheral vascular disease (n=33). Controls
were aged 64.3±12.1 years with total cholesterol of
6.1±1.1 mmol/L and aortic compliance of 1.14±0.46%/10
mm Hg [1.33 kPa] (P<0.002 versus arteriopaths).
Subset analysis revealed that patients with the greatest number
of cardiovascular risk factors and events (n=5) had the
stiffest aortas (aortic compliance, 0.58±0.15%/10 mm Hg [1.33
kPa]) compared with those patients with the median and mean (n=2)
number of risk factors and events (aortic compliance,
0.80±0.50%/10 mm Hg [1.33 kPa]; P<0.02). The
data suggest that a significant inverse relation exists between
presumed atherosclerotic load (as assessed by the number of
cardiovascular risk factors and events) and aortic
compliance determined noninvasively based on aortic pulse wave velocity
measurements. If these findings are confirmed by prospective,
longitudinal follow-up studies, such measurements may prove useful as a
noninvasive marker of vascular risk.
© 1998 American Heart Association, Inc.
Third Workshop on Structure and Function of Large Arteries: Part III
Relation Between Number of Cardiovascular Risk Factors/Events and Noninvasive Doppler Ultrasound Assessments of Aortic Compliance
Key Words: aorta • pulse wave velocity • atherosclerosis • risk factors • cardiovascular diseases • myocardial infarction
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