From the Alfred and Baker Medical Unit, Alfred Hospital, and the Baker
Medical Research Institute, Melbourne, Australia.
Correspondence to Dr Christoph Gatzka, Alfred Heart Centre, Commercial Rd, Prahran, Vic 3181, Australia. E-mail cdg{at}ee.latrobe.edu.au
Abstract
Abstract—To elucidate the
relationship between coronary artery disease (CAD), aortic
stiffness, and left ventricular structure, we recruited 55
subjects (33 men; average age, 63±1 years) with previously unknown CAD
from a healthy general population sample, as well as 55 control
subjects matched for gender, age, and serum cholesterol
level. We measured arterial blood pressure and the
systolic expansion of the transverse aorta and left
ventricular structure by
echocardiography. Aortic stiffness was higher in
CAD patients than in controls, with a brachial pulse pressure of 59±3
versus 52±2 mm Hg and stiffness indices of
Ep=212±26 versus 123±13 kN/m2 and ß=16±2
versus 9±1 (all P<0.01). Mean arterial
pressure was similar in both groups during the measurements (95±2
versus 93±2 mm Hg, P=NS). Most CAD patients
(61%) were in the highest stiffness quartile defined by the normal
control values (P<0.05 versus control). Left
ventricular mass index was also higher in CAD patients than
in matched controls (139±5 versus 123±4 g/m2,
P<0.05). We conclude that aortic stiffness and left
ventricular mass are increased in subjects newly diagnosed
as having CAD. This might explain previously reported associations of
an increased mortality, particularly from CAD, found among subjects
with elevated pulse pressures.
© 1998 American Heart Association, Inc.
Third Workshop on Structure and Function of Large Arteries: Part III
Relation Between Coronary Artery Disease, Aortic Stiffness, and Left Ventricular Structure in a Population Sample
Key Words: aorta • arterial compliance • coronary artery disease • ventricular function, left
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