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(Hypertension. 1998;32:869-874.)
© 1998 American Heart Association, Inc.

Scientific Contributions

Parameters of Lymphocyte Na⁺-Ca²⁺ Regulation and Blood Pressure

The Gender Effect

Makoto Horiguchi; Masayuki Kimura; Joan Skurnick; ; Abraham Aviv

From the Hypertension Research Center and the Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of NJ, New Jersey Medical School, Newark, NJ.

Correspondence to Abraham Aviv, Hypertension Research Center, University of Medicine and Dentistry of NJ, New Jersey Medical School, 185 S Orange Ave, Room F-464, Newark, NJ 07103. E-mail avivab{at}umdnj.edu

Abstract—Alterations in cellular Ca²⁺ and Na⁺ regulation play a role in the pathogenesis of essential hypertension. Using peripheral lymphocytes from 68 normal persons, we observed the following relationships for major cellular Ca²⁺ regulatory parameters. Among men and women, Na⁺-Ca²⁺ exchanger activity was positively correlated with the resting cytosolic free Ca²⁺ ([Ca²⁺]_c) (r=0.43, P=0.0003), and the resting [Ca²⁺]_c was positively correlated with cytosolic Na⁺ ([Na⁺]_c) (r=0.50, P=0.0001). For men only, store-operated Ca²⁺ entry was positively correlated with Na⁺-Ca²⁺ exchanger activity (r=0.63, P=0.0001). In addition, systolic and diastolic blood pressures were positively correlated with [Na⁺]_c in men (r=0.53, P=0.001, and r=0.41, P=0.017, respectively) but not in women (r=0.30, P=0.088, and r=0.24, P=0.17, respectively). Some of the relationships between cellular and blood pressure parameters were confounded by serum triglycerides. These observations indicate a gender effect on cellular Ca²⁺-Na⁺ regulation and its relationship with blood pressure.

Key Words: hypertension, essential • sodium • calcium • gender • blacks • ethnicity

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