(Hypertension. 1998;32:935-938.)
© 1998 American Heart Association, Inc.
Scientific Contributions |
G Protein ß3 Subunit Variant and Essential Hypertension in Japanese
From the Graduate School of Human and Environmental Studies, Kyoto University, Kyoto (N.K., Y. Yamori); the Institute for Adult Diseases Asahi Life Foundation (T.S.), Tokyo; and the Department of Cardiovascular Medicine, Graduate School of Medicine, Tokyo University, Tokyo (H.M., H.K., Y. Yazaki), Japan.
Abstract—Enhanced G protein
activation has been implicated to underlie the increased sodium-proton
transport in blood cells, an impaired characteristic observed in 30%
to 50% of patients with essential hypertension. Recently, significant
association between a C825T polymorphism of the gene encoding the G
protein ß3 subunit and hypertension was demonstrated in a white
population, together with the finding that the T825 variant might be
related to alternative splicing through unidentified mechanisms. We
therefore investigated the disease relevance of this candidate gene by
conducting an association study in a relatively large Japanese
population. Participants comprised 718 hypertensive case subjects
(without diabetes mellitus), 515 normotensive control subjects, and 191
hypertensive subjects with borderline or established diabetes mellitus;
all individuals were recruited at a single institution.
Genotype distribution of the C825T polymorphism was
compared between hypertensive subjects, with or without diabetes, and
the control group with 
2 statistics. No significant
association was observed in the present study. Results were still
not significant when the case group was subdivided according to more
stringent classification criteria. Allele frequencies of T825
proved to be almost concordant among the 3 study groups and higher in
Japanese (49.0% to 49.6%) compared with a reported prevalence of 25%
to 31% in whites. Our data suggest that the T825 variant of the G
protein ß3 subunit gene is unlikely to constitute major
susceptibility for essential hypertension in the Japanese population
studied. However, further investigation is required to answer the
question of whether the lack of association reflects ethnic differences
in the nature of genetic susceptibility loci.
Key Words: hypertension, essential • association • case-control studies • G proteins • genetics
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