| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Hypertension. 1999;33:1049-1051.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
G-Protein ß3 Subunit C825T Variant and Ambulatory Blood Pressure in Essential Hypertension
From the Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinikum Benjamin Franklin, Free University of Berlin (Germany).
Correspondence to Prof Dr Arya M. Sharma, Medizinische Klinik IV, Klinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany. E-mail sharma{at}zedat.fu-berlin.de
Abstract—Recent studies have
identified a novel polymorphism (C825T) of the gene encoding the
ß3 subunit of heterotrimeric G proteins (Gß3)
associated with enhanced activation of G proteins, which appears to be
more common in hypertensive patients. In the present study we
examine the relationship between this genetic variant and hypertension
in 479 white patients with established essential hypertension recruited
from the hypertension clinic of the Universitätsklinikum
Benjamin Franklin in Berlin, Germany, and 1000 normotensive gender- and
age-matched controls. All patients were screened for the presence of
secondary hypertension and were further characterized by ambulatory
blood pressure measurements performed in 295 treated and 184 untreated
patients. Genotype distribution for the
Gß3-C825T genotype in patients
(CC=204, CT=224, TT=51)
was significantly different from that in controls
(CC=514, CT=412, TT=74;
2=11.5, P<0.01), and the T allele
was associated with an odds ratio of 1.5 (95% CI, 1.1 to 2.2) versus
non-T carriers for the presence of hypertension. However, in both the
whole group and the untreated subgroup, blood pressure levels between
the genotypic groups were virtually identical. Furthermore, age of
onset of hypertension and number of antihypertensive medications (in
treated patients) were similar between the genotypic groups. Thus,
while our data confirm the association between the
Gß3-C825T variant and essential hypertension, they do
not support the hypothesis that this marker is associated with more
severe blood pressure in patients with already established
hypertension.
Key Words: angiotensinogen • angiotensin-converting enzyme • hypertension, essential • genetics • blood pressure monitoring, ambulatory • hypertrophy, left ventricular
This article has been cited by other articles:
 |
|
 |
|
  N. Eynon, J. Oliveira, Y. Meckel, M. Sagiv, C. Yamin, M. Sagiv, R. Amir, and J. A. Duarte The guanine nucleotide binding protein {beta} polypeptide 3 gene C825T polymorphism is associated with elite endurance athletes Exp Physiol, March 1, 2009; 94(3): 344 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sartori, A. Semplicini, W. Siffert, P. Mormino, A. Mazzer, F. Pegoraro, L. Mos, M. Winnicki, and P. Palatini G-Protein {beta}3-Subunit Gene 825T Allele and Hypertension: A Longitudinal Study in Young Grade I Hypertensives Hypertension, November 1, 2003; 42(5): 909 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ruiz-Velasco and S. R. Ikeda A splice variant of the G protein {beta}3-subunit implicated in disease states does not modulate ion channels Physiol Genomics, April 16, 2003; 13(2): 85 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sedlacek, M. Fischer, J. Erdmann, C. Hengstenberg, S. Holmer, S. Kurzinger, M. Muscholl, A. Luchner, G. A. Riegger, H.-W. Hense, et al. Relation of the G Protein {beta}3-Subunit Polymorphism With Left Ventricle Structure and Function Hypertension, August 1, 2002; 40(2): 162 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Swynghedauw Susceptibility-conferring polymorphic genotypes in cardiovascular multifactorial syndromes Eur. Heart J., February 2, 2002; 23(4): 271 - 273. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch, R. Erbel, and W. Siffert Genetic determinants of coronary vasomotor tone in humans Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1465 - H1468. [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Morrison, P. A. Doris, A. R. Folsom, F. J. Nieto, E. Boerwinkle, and R. A. Hegele G-Protein {beta}3 Subunit and {{alpha}}-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke Editorial Comment : Candidate Genes for Stroke: If Elected, Will They Serve? Stroke, April 1, 2001; 32(4): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hengstenberg, H. Schunkert, B. Mayer, A. Doring, H. Lowel, H.-W. Hense, M. Fischer, G. A.J Riegger, and S. R Holmer Association between a polymorphism in the G protein {beta}3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction Cardiovasc Res, March 1, 2001; 49(4): 820 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Wuthrich, S. Cicvara, C. Booy, U. Widmer, and U. Binswanger The 825C/T polymorphism of the G-protein subunit {beta}3 does not influence blood pressure and renal function in kidney transplant recipients Nephrol. Dial. Transplant., October 1, 2000; 15(10): 1663 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Siffert G protein {beta}3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy Nephrol. Dial. Transplant., September 1, 2000; 15(9): 1298 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rosskopf, S. Busch, I. Manthey, and W. Siffert G Protein {beta}3 Gene : Structure, Promoter, and Additional Polymorphisms Hypertension, July 1, 2000; 36(1): 33 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Poch, D. Gonzalez, E. Gomez-Angelats, M. Enjuto, J. C. Pare, F. Rivera, and A. de la Sierra G-Protein {beta}3 Subunit Gene Variant and Left Ventricular Hypertrophy in Essential Hypertension Hypertension, January 1, 2000; 35(1): 214 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Dong, H. Zhu, G. A. Sagnella, N. D. Carter, D. G. Cook, and F. P. Cappuccio Association Between the C825T Polymorphism of the G Protein {beta}3-Subunit Gene and Hypertension in Blacks Hypertension, December 1, 1999; 34(6): 1193 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Siffert, D. Rosskopf, R. Erbel, E. Ritz, E. Brand, S.-M. Herrmann, and L. Tiret G Protein {beta}3 Subunit 825T Allele and Hypertension • Response Hypertension, November 1, 1999; e8(5): . [Full Text]
|
|
|
|
 |
|
 W. SIFFERT, P. FORSTER, K.-H. JÖCKEL, D. A. MVERE, B. BRINKMANN, C. NABER, R. CROOKES, A. D. P. HEYNS, J. T. EPPLEN, J. FRIDEY, et al. Worldwide Ethnic Distribution of the G Protein {beta}3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals J. Am. Soc. Nephrol., September 1, 1999; 10(9): 1921 - 1930. [Abstract] [Full Text]
|
|
|
|
|
|
J. BEIGE, S. ENGELI, J. RINGEL, G. OFFERMANN, A. DISTLER, and A. M. SHARMA Donor G Protein {beta}3 Subunit 825TT Genotype Is Associated with Reduced Kidney Allograft Survival J. Am. Soc. Nephrol., August 1, 1999; 10(8): 1717 - 1721. [Abstract] [Full Text]
|
|
|
|
|
|
T. Rankinen, T. Rice, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, and C. Bouchard G protein {beta}3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study Physiol Genomics, February 28, 2002; 8(2): 151 - 157. [Abstract] [Full Text] [PDF]
|
|