(Hypertension. 1999;33:1049-1051.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
G-Protein ß3 Subunit C825T Variant and Ambulatory Blood Pressure in Essential Hypertension
From the Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinikum Benjamin Franklin, Free University of Berlin (Germany).
Correspondence to Prof Dr Arya M. Sharma, Medizinische Klinik IV, Klinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany. E-mail sharma{at}zedat.fu-berlin.de
Abstract—Recent studies have
identified a novel polymorphism (C825T) of the gene encoding the
ß3 subunit of heterotrimeric G proteins (Gß3)
associated with enhanced activation of G proteins, which appears to be
more common in hypertensive patients. In the present study we
examine the relationship between this genetic variant and hypertension
in 479 white patients with established essential hypertension recruited
from the hypertension clinic of the Universitätsklinikum
Benjamin Franklin in Berlin, Germany, and 1000 normotensive gender- and
age-matched controls. All patients were screened for the presence of
secondary hypertension and were further characterized by ambulatory
blood pressure measurements performed in 295 treated and 184 untreated
patients. Genotype distribution for the
Gß3-C825T genotype in patients
(CC=204, CT=224, TT=51)
was significantly different from that in controls
(CC=514, CT=412, TT=74;
2=11.5, P<0.01), and the T allele
was associated with an odds ratio of 1.5 (95% CI, 1.1 to 2.2) versus
non-T carriers for the presence of hypertension. However, in both the
whole group and the untreated subgroup, blood pressure levels between
the genotypic groups were virtually identical. Furthermore, age of
onset of hypertension and number of antihypertensive medications (in
treated patients) were similar between the genotypic groups. Thus,
while our data confirm the association between the
Gß3-C825T variant and essential hypertension, they do
not support the hypothesis that this marker is associated with more
severe blood pressure in patients with already established
hypertension.
Key Words: angiotensinogen • angiotensin-converting enzyme • hypertension, essential • genetics • blood pressure monitoring, ambulatory • hypertrophy, left ventricular
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