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(Hypertension. 1999;33:1338-1341.)
© 1999 American Heart Association, Inc.

Scientific Contributions

Factor V Leiden and Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in an East Anglian Preeclampsia Cohort

Kevin M. O'Shaughnessy; Beiyuan Fu; Franco Ferraro; Ian Lewis; Sarah Downing; Nick H. Morris

From the Clinical Pharmacology Unit, Department of Medicine, University of Cambridge Clinical School, Cambridge, UK (K.M.O., B.F., F.F., I.L., S.D.); and the Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital and Central Middlesex Hospital Trust, London, UK (N.H.M.).

Correspondence to Dr Kevin M. O'Shaughnessy, Clinical Pharmacology Unit, Level 6, ACCI, Box 110, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. E-mail kmo22{at}medschl.cam.ac.uk

Abstract—Preeclampsia is a heritable condition that develops as a result of widespread vascular endothelial dysfunction. The thrombotic tendency in this condition has suggested a number of candidate genes, and there have been recent reports of positive association with the Leiden variant of factor V and the thermolabile variant of methylenetetrahydrofolate reductase. We attempted to reproduce these results in a large cohort of well-characterized women with preeclampsia, recruited prospectively within the East Anglian region of the United Kingdom. Women in the preeclampsia cohort (n=283) were genotyped for both the Leiden variant (G1691A) of factor V and the thermolabile variant (C677T) of methylenetetrahydrofolate reductase. Genotype and allele frequencies were compared with those of 2 control groups, one consisting of women recruited prospectively (n=100) from the same maternity hospital as the subjects and another consisting of normotensive women (n=100) from East Anglia. No significant differences were detected. Specifically, the carrier rate for the Leiden variant was 5.3% in the preeclampsia group and 5.5% in the combined control group. T677 homozygotes for methylenetetrahydrofolate reductase were 11% and 11.5% in the 2 groups, respectively. We conclude that there is no evidence of association of preeclampsia with either of these 2 polymorphisms in our study population.

Key Words: preeclampsia • thrombosis • polymorphisms • factor V • methylenetetrahydrofolate reductase • association study

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