(Hypertension. 1999;34:625-630.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
Genome Scan for Blood Pressure Loci in Mice
From the Division of Human Cancer Genetics and the Comprehensive Cancer Center (F.A.W.), Ohio State University, Columbus, Ohio; the Department of Medicine and Center for Molecular Genetics (D.T.O., L.U.Y.), University of California and VA Healthcare System, San Diego; the Howard Hughes Medical Institute (E.R.), Division of Cellular and Molecular Medicine, University of California, San Diego; the Genetics Program (G.K., G.S.), University of Kansas, Lawrence; and the Department of Family and Preventive Medicine (C.C.B., D.T.), University of California, San Diego.
Correspondence to Fred A. Wright, PhD, Assistant Professor, Division of Human Cancer Genetics, The Ohio State University, 420 W 12th Ave, Room 464A, Columbus, OH 43210. E-mail wright-4{at}medctr.osu.edu
Abstract—Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was observed in the F2s on chromosome 10 (logarithm of the odds score [LOD]=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional suggestive LODs on chromosomes 2, 6, 8, and 18. In addition, several suggestive linkages were observed for phenotypes associated with human hypertension. Our study is the first reported genome-wide linkage scan for blood pressure genes in the mouse.
Key Words: linkage • hypertension, genetic • mice • genes
This article has been cited by other articles:
 |
|
 |
|
  A. Y. Deng Positional Cloning of Quantitative Trait Loci for Blood Pressure: How Close Are We?: A Critical Perspective Hypertension, April 1, 2007; 49(4): 740 - 747. [Full Text] [PDF]
|
|
|
|
 |
|
 C. B.M. Oudejans, J. Mulders, A. M.A. Lachmeijer, M. van Dijk, A. A.M. Konst, B. A. Westerman, I. J. van Wijk, P. A.J. Leegwater, H. D. Kato, T. Matsuda, et al. The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas Mol. Hum. Reprod., August 1, 2004; 10(8): 589 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Fries, P. Mahboubi, N. R. Mahapatra, S. K. Mahata, N. J. Schork, G. W. Schmid-Schoenbein, and D. T. O'Connor Neuroendocrine Transcriptome in Genetic Hypertension: Multiple Changes in Diverse Adrenal Physiological Systems Hypertension, June 1, 2004; 43(6): 1301 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. DiPetrillo, S.-W. Tsaih, S. Sheehan, C. Johns, P. Kelmenson, H. Gavras, G. A. Churchill, and B. Paigen Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice Physiol Genomics, April 13, 2004; 17(2): 215 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Welch, S. Bretschger, P.-Z. Wen, M. Mehrabian, N. Latib, J. Fruchart-Najib, J. C. Fruchart, C. Myrick, and A. J. Lusis Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain Physiol Genomics, March 12, 2004; 17(1): 48 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. L. Woo and I. Kurtz Mapping blood pressure loci in (A/J x B6)F2 mice Physiol Genomics, November 11, 2003; 15(3): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hartner, N. Cordasic, B. Klanke, R. Veelken, and K. F. Hilgers Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice Nephrol. Dial. Transplant., October 1, 2003; 18(10): 1999 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wong, N. R. Mahapatra, S. Chitbangonsyn, P. Mahboubi, M. Mahata, S. K. Mahata, and D. T. O'Connor The angiotensin II receptor (Agtr1a): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse Physiol Genomics, June 24, 2003; 14(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Cowley Jr. Genomics and homeostasis Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R611 - R627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sugiyama, G. A. Churchill, R. Li, L. J. M. Libby, T. Carver, K.-I. Yagami, S. W. M. John, and B. Paigen QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice Physiol Genomics, July 12, 2002; 10(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Ryan, S. P. Didion, D. R. Davis, F. M. Faraci, and C. D. Sigmund Endothelial Dysfunction and Blood Pressure Variability in Selected Inbred Mouse Strains Arterioscler. Thromb. Vasc. Biol., January 1, 2002; 22(1): 42 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. SAAD, M. R. GARRETT, and J. P. RAPP Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains Physiol Genomics, January 19, 2001; 4(3): 201 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stoll, A. E. Kwitek-Black, A. W. Cowley Jr., E. L. Harris, S. B. Harrap, J. E. Krieger, M. P. Printz, A. P. Provoost, J. Sassard, and H. J. Jacob New Target Regions for Human Hypertension via Comparative Genomics Genome Res., April 1, 2000; 10(4): 473 - 482. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. P. Rapp Genetic Analysis of Inherited Hypertension in the Rat Physiol Rev, January 1, 2000; 80(1): 135 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Garrett and J. P. Rapp Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats Physiol Genomics, February 28, 2002; 8(2): 81 - 86. [Abstract] [Full Text] [PDF]
|
|