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(Hypertension. 1999;34:790-794.)
© 1999 American Heart Association, Inc.

Scientific Contributions

Modulation of Coronary Flow and Cardiomyocyte Size by Sensory Fibers

Angelina Zanesco; Soraia K. P. Costa; Sonia R. Riado; Luciana P. Nathan; Claudia F. de Oliveira; Iara M. S. De Luca; Edson Antunes; Gilberto De Nucci

From the Department of Physical Education, Biosciences Institute (A.Z.), Paulista State University, Rio Claro (SP) and the Department of Pharmacology, Faculty of Medical Sciences (S.K.P.C., S.R.R., L.P.N., C.F. de O., E.A., G. De N.); and Department of Histology and Embryology, Biology Institute, State University of Campinas, (I.M.S. De L.), Campinas (SP), Brazil.

Correspondence to Angelina Zanesco, PhD, Department of Physical Education, Biosciences Institute, Paulista State University, Av 24A No. 1515, Bela Vista, CEP 13506-900, Rio Claro (SP), Brazil. E-mail azanesco{at}bestway.com.br

Abstract—Cardiac tissue is densely innervated by sensory neurons that are believed to play important modulatory roles in cardiac functions. In this study, pretreatment of neonate rats with capsaicin was performed. In adult rats, cardiomyocyte size and amount of fibrous tissue in left ventricles as well as in vitro coronary flow were evaluated. The chronotropic and inotropic responses to ß-adrenoceptor agonists (norepinephrine and isoproterenol), muscarinic agonists (carbachol and pilocarpine), and calcitonin gene–related peptide (CGRP) were also investigated with the use of the isolated right atria preparation. Capsaicin pretreatment significantly (P<0.05) reduced both basal coronary flow (18% reduction) and cardiomyocyte size (34% reduction) without affecting the amount of fibrous tissues in the left ventricles. The positive inotropic and chronotropic effects in response to norepinephrine in the isolated rat heart did not significantly differ between control and capsaicin-treated rats. Similarly, the positive chronotropic effects in response to norepinephrine, isoproterenol, and CGRP as well as the negative chronotropic responses to carbachol and pilocarpine in the isolated right atria were not affected by capsaicin pretreatment. Our data are consistent with the suggestion that reductions of both basal coronary flow and cardiomyocyte size seen in hearts from capsaicin-pretreated rats may be consequences of CGRP depletion. The cardiomyocyte size reduction produced by capsaicin treatment may be related to a modulatory role of CGRP as a growth factor.

Key Words: capsaicin • receptors, muscarinic • receptors, adrenergic, beta • neuropeptides • peptides