(Hypertension. 1999;34:1202.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
Impeded Alveolar-Capillary Gas Transfer With Saline Infusion in Heart Failure
From the Istituto di Cardiologia dell’Università degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Fondazione "Monzino," I.R.C.C.S., Milano, Italy.
Correspondence to Marco Guazzi, MD, PhD, Istituto di Cardiologia, Via C. Parea, 4, 20138 Milano, Italy. E-mail Maurizio.Guazzi{at}unimi.it
Abstract—The microvascular pulmonary endothelium barrier is critical in preventing interstitial fluid overflow and deterioration in gas diffusion. The role of endothelium in transporting small solutes in pathological conditions, such as congestive heart failure (CHF), has not been studied. Monitoring of pulmonary gas transfer during saline infusion in CHF was used to probe this issue. Carbon monoxide diffusion (DLCO), its membrane diffusion (DM) and capillary blood volume (VC) subcomponents, and mean right atrial (rap) and mean pulmonary wedge (wpp) pressures after saline or 5% D-glucose solution infusions were compared with baseline in 26 moderate CHF patients. Saline was also tested in 13 healthy controls. In patients, 750 mL of saline lowered DLCO (-8%, P<0.01 versus baseline), DM (-10%, P<0.01 versus baseline), aldosterone (-29%, P<0.01 versus baseline), renin (-52%, P<0.01 versus baseline), and hematocrit (-6%, P<0.05 versus baseline) and increased VC (20%, P<0.01 versus baseline), without changing rap and wpp. Saline at 150 mL produced qualitatively similar results regarding DLCO (-5%, P<0.01 versus baseline), DM (-7%, P<0.01 versus baseline), VC (9%, P<0.01 versus baseline), rap, wpp, aldosterone (-9%, P<0.05 versus baseline), and renin (-14%, P<0.05 versus baseline). Glucose solution (750 mL), on the contrary, increased DLCO (5%, P<0.01 versus 750 mL of saline) and DM (11%, P<0.01 versus 750 mL of saline) and decreased VC (-9, P<0.01 versus 750 mL of saline); aldosterone (-40%), renin (-41%), hematocrit (-3%), rap, and wpp behaved as they did after saline infusion. In controls, responses to both saline amounts were similar to responses in CHF patients regarding aldosterone, renin, hematocrit, rap, and wpp, whereas DLCO, DM, and VC values tended to rise. Hindrance to gas transfer (reduced DLCO and DM) with salt infusion in CHF, despite an increase in VC and no variations in pulmonary hydrostatic forces, indicates an upregulation in sodium transport from blood to interstitium with interstitial edema. Redistribution of blood from the lungs, facilitating interstitial fluid reabsorption, or sodium uptake from the alveolar lumen by the sodium-glucose cotransport system might underlie the improved alveolar-capillary conductance with glucose.
Key Words: capillaries • epithelium • glucose • heart failure • sodium
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