(Hypertension. 1999;34:1265.)
© 1999 American Heart Association, Inc.
Scientific Contributions |
Elements of a Paracrine Tubular Renin-Angiotensin System Along the Entire Nephron
From the Departments of Human Genetics (A.R., T.M., H.F.D., K.W., J.-M.L.), Obstetrics and Gynecology (L.Z., K.W.), and Pathology (D.A.T.), University of Utah School of Medicine, Salt Lake City; the Howard Hughes Medical Institute (C.W.C., E.H., S.Z., T.C., J.-M.L.) and the US Department of Veterans Affairs (T.I., D.A.T.), Salt Lake City, Utah; and the Department of Biochemistry (T.I.), Vanderbilt University, Nashville, Tenn.
Abstract—The renin-angiotensin system is a major regulator of body sodium, predominantly through the actions of intrarenal angiotensin II of unclear origin. We show that polarized epithelium of the proximal tubule synthesizes and secretes angiotensinogen at its apical side and that the protein can be detected in urine as a function of dietary sodium. Furthermore, we demonstrate that renin is expressed and secreted in a restricted nephron segment, the connecting tubule, also in a sodium-dependent fashion. A paracrine renin-angiotensin system operating along the entire nephron may contribute to long-term arterial pressure regulation by integrating distant tubular sodium-reabsorbing functions.
Key Words: angiotensinogen • kidney • renin • renin-angiotensin system • sodium, dietary
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