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(Hypertension. 2000;35:643.)
© 2000 American Heart Association, Inc.

Scientific Contributions

Age-Related Changes in Renal Cyclic Nucleotides and Eicosanoids in Response to Sodium Intake

Lesley J. Millatt; Helmy M. Siragy

From the Department of Internal Medicine, University of Virginia Health System, Charlottesville, Va.

Correspondence to Helmy M. Siragy, MD, Department of Internal Medicine, Box 482, University of Virginia Health System, Charlottesville, VA 22908. E-mail hms7a{at}virginia.edu

Abstract—The signaling molecules cGMP, cAMP, prostaglandin E₂ (PGE₂), and prostaglandin F₂ (PGF₂) play important roles in mediating the response of the kidney to changes in dietary sodium intake. We used a renal microdialysis technique in conscious rats to address the hypothesis that the renal ability to produce these mediators in response to dietary sodium intake is altered during maturation. Young (4-week-old) or adult (6-month-old) rats were studied after the consumption for 5 days of diets containing low (0.04% NaCl), normal (0.28% NaCl), or high (4.0% NaCl) levels of sodium. Plasma renin activity was significantly increased by low-sodium diet and significantly decreased by high-sodium diet, with no significant difference between the responses of the 2 age groups. Renal interstitial fluid (RIF) levels of cGMP, cAMP, PGE₂, and PGF₂ on normal-sodium diet were similar in the 2 age groups. Low-sodium diet caused a significant increase in RIF levels of all 4 mediators, with no significant differences between the responses of the 2 age groups. High-sodium diet also caused a significant increase in RIF levels of all 4 mediators. However, RIF production of cGMP, cAMP, and PGE₂ was significantly greater, and RIF PGF₂ production was significantly lower, in young rats compared with adult rats. These data demonstrate that the kidneys of young and adult rats respond to dietary sodium restriction in a similar manner but that there are age-related changes in the renal response to sodium loading.

Key Words: age • cyclic AMP • cyclic GMP • kidney • prostaglandins • sodium • rats

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