(Hypertension. 2000;35:e1.)
© 2000 American Heart Association, Inc.
Hypertension Electronic Pages |
Long-Term Telemetric Recording of Arterial Pressure and Heart Rate in Mice Fed Basal and High NaCl Diets
From the Department of Cell Biology, University of Alabama at Birmingham, Ala.
Correspondence to Scott H. Carlson, PhD, Department of Cell Biology, 1670 University Blvd, VH 601 Box 302, Birmingham, AL 35294-0019. E-mail scarlson{at}uab.edu
Abstract—Research examining the
control of arterial pressure in mice has primarily relied
on tail-cuff plethysmography and, more recently, on tethered
arterial catheters. In contrast, the radiotelemetry method
has largely become the "gold standard" for long-term monitoring of
arterial pressure and heart rate in rats. Whereas smaller
telemetry probes have recently been developed, no published studies
have used radiotelemetric monitoring of arterial pressure
in mice, largely because of a relatively low success rate in small mice
(ie, <30 g body weight). We report on the development of a protocol
for the use of these probes to continuously monitor
arterial pressure and heart rate in mice as small as
19 g body weight. To test the accuracy and reliability of this
method, adult C57/BL6 mice were monitored for 3 weeks during exposure
to a basal followed by a high NaCl diet. The results demonstrate that
carotid and aortic placements of the telemetry probe provide equally
accurate monitoring of arterial pressure and heart rate,
but the carotid placement has a much greater rate of success. Exposure
to a high NaCl diet increases both the amplitude of the
arterial pressure rhythm (+ 6.0±0.6 mm Hg, 
32%)
and the average mean arterial pressure (+ 8.6±1.1
mm Hg, 8%), as would be predicted from previous studies in
NaCl-resistant rats. Thus, the data demonstrate that telemetric
recording of long-term arterial pressure and heart
rate provides a powerful tool with which to define the mechanisms of
cardiovascular control in mice.
Key Words: telemetry • salt • circadian rhythm • transgenic mice
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