(Hypertension. 2000;35:1183.)
© 2000 American Heart Association, Inc.
Review Articles |
Angiotensin II and the Heart
On the Intracrine Renin-Angiotensin System
From the Department of Pharmacology (W.C.D.M.), Medical Sciences Campus, University of Puerto Rico, San Juan, and the Department of Pharmacology (A.H.J.D.), Erasmus University Rotterdam, Rotterdam, the Netherlands.
Correspondence to Dr Walmor C. De Mello, Department of Pharmacology, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-5067.
Abstract—The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca2+ current.
Key Words: angiotensin • heart • hypertrophy • receptors, angiotensin • renin • signal transduction
This article has been cited by other articles:
 |
|
 |
|
  K. D. Pendergrass, N. T. Pirro, B. M. Westwood, C. M. Ferrario, K. B. Brosnihan, and M. C. Chappell Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H10 - H20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C De Mello Intracellular and extracellular renin have opposite effects on the regulation of heart cell volume. Implications for myocardial ischaemia Journal of Renin-Angiotensin-Aldosterone System, June 1, 2008; 9(2): 112 - 118. [Abstract] [PDF]
|
|
|
|
 |
|
 P. J. Garabelli, J. G. Modrall, J. M. Penninger, C. M. Ferrario, and M. C. Chappell Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart Exp Physiol, May 1, 2008; 93(5): 613 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Vesely and V. Dilsizian Nuclear Cardiac Stress Testing in the Era of Molecular Medicine J. Nucl. Med., March 1, 2008; 49(3): 399 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. C. Li and J. L. Zhuo Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells Am J Physiol Cell Physiol, July 1, 2007; 293(1): C367 - C378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M Maharsy, L. N Kadi, N. G Issa, K. M Bitar, A. H Der-Boghossian, R. Abrahamian, and A. B Bikhazi Cross-talk related to insulin and angiotensin II binding on myocardial remodelling in diabetic rat hearts Journal of Renin-Angiotensin-Aldosterone System, June 1, 2007; 8(2): 59 - 65. [Abstract] [PDF]
|
|
|
|
|
|
W. C De Mello, C. M Ferrario, and J. A Jessup Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart Journal of Renin-Angiotensin-Aldosterone System, June 1, 2007; 8(2): 74 - 80. [Abstract] [PDF]
|
|
|
|
|
|
J. L Zhuo and X. C Li Review: Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells Journal of Renin-Angiotensin-Aldosterone System, March 1, 2007; 8(1): 23 - 33. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Telemaque and J. L. Mehta Sepsis, Calcineurin, and Cardiac Dysfunction: The Saga of Life and Death J. Am. Coll. Cardiol., January 30, 2007; 49(4): 500 - 501. [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Ocaranza, I. Godoy, J. E. Jalil, M. Varas, P. Collantes, M. Pinto, M. Roman, C. Ramirez, M. Copaja, G. Diaz-Araya, et al. Enalapril Attenuates Downregulation of Angiotensin-Converting Enzyme 2 in the Late Phase of Ventricular Dysfunction in Myocardial Infarcted Rat Hypertension, October 1, 2006; 48(4): 572 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roig Usefulness of neurohormonal markers in the diagnosis and prognosis of heart failure Eur. Heart J. Suppl., September 1, 2006; 8(suppl_E): E12 - E17. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Paul, A. Poyan Mehr, and R. Kreutz Physiology of local Renin-Angiotensin systems. Physiol Rev, July 1, 2006; 86(3): 747 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Lavoie, X. Liu, R. A. Bianco, T. G. Beltz, A. K. Johnson, and C. D. Sigmund Evidence Supporting a Functional Role for Intracellular Renin in the Brain Hypertension, March 1, 2006; 47(3): 461 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Wichi, S. B. Souza, D. E. Casarini, M. Morris, M. L. Barreto-Chaves, and M. C. Irigoyen Increased blood pressure in the offspring of diabetic mothers Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1129 - R1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S Anavekar and S. D Solomon Angiotensin II receptor blockade and ventricular remodelling Journal of Renin-Angiotensin-Aldosterone System, March 1, 2005; 6(1): 43 - 48. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Saeed, A. Slowik, A. Borratynska, T. Dziedzic, A. Szczudlik, A. Kieltyka, and D. A. Figlewicz ACE and Subarachnoid Hemorrhage: Strategies for Genetics of Stroke * Response: Stroke, December 1, 2004; 35(12): 2752 - 2753. [Full Text] [PDF]
|
|
|
|
|
|
U. Vongvatcharanon, S. Vongvatcharanon, N. Radenahmad, P. Kirirat, P. Intasaro, P. Sobhon, and T. Parker Angiotensin II may mediate apoptosis via AT1-receptors in the rat cardiac conduction system Journal of Renin-Angiotensin-Aldosterone System, September 1, 2004; 5(3): 135 - 140. [Abstract] [PDF]
|
|
|
|
|
|
W. C. De Mello and J. Monterrubio Intracellular and Extracellular Angiotensin II Enhance the L-Type Calcium Current in the Failing Heart Hypertension, September 1, 2004; 44(3): 360 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishiyama, P. E. Gallagher, D. B. Averill, E. A. Tallant, K. B. Brosnihan, and C. M. Ferrario Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors Hypertension, May 1, 2004; 43(5): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Averill, Y. Ishiyama, M. C. Chappell, and C. M. Ferrario Cardiac Angiotensin-(1-7) in Ischemic Cardiomyopathy Circulation, October 28, 2003; 108(17): 2141 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Re Intracellular Renin and the Nature of Intracrine Enzymes Hypertension, August 1, 2003; 42(2): 117 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Re Implications of intracrine hormone action for physiology and medicine Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H751 - H757. [Full Text] [PDF]
|
|
|
|
|
|
W D. Strain and N. Chaturvedi Review: The renin-angiotensin-aldosterone system and the eye in diabetes Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 243 - 246. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Wang, D. Slembrouck, J. Tan, L. Arckens, F. H. H. Leenen, P. J. Courtoy, and W. P. De Potter Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1811 - H1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bartel, B. Hoch, D. Vetter, and E.-G. Krause Expression of Human Angiotensinogen-Renin in Rat: Effects on Transcription and Heart Function Hypertension, February 1, 2002; 39(2): 219 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Eto, Y. Ohya, Y. Nakamura, I. Abe, and M. Iida Intracellular Angiotensin II Stimulates Voltage-Operated Ca2+ Channels in Arterial Myocytes Hypertension, February 1, 2002; 39(2): 474 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M Filipeanu, R. H Henning, S A. Nelemans, and D. de Zeeuw Review: Intracellular angiotensin II: from myth to reality? Journal of Renin-Angiotensin-Aldosterone System, December 1, 2001; 2(4): 219 - 226. [PDF]
|
|
|
|
 |
|
 G. Arcaro, A. Solini, T. Monauni, A. Cretti, B. Brunato, A. Lechi, R. Fellin, M. Caputo, C. Cocco, E. Bonora, et al. ACE Genotype and Endothelium-Dependent Vasodilation of Conduit Arteries and Forearm Microcirculation in Humans Arterioscler. Thromb. Vasc. Biol., August 1, 2001; 21(8): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsutamoto, A. Wada, T. Matsumoto, K. Maeda, N. Mabuchi, M. Hayashi, T. Tsutsui, M. Ohnishi, M. Sawaki, M. Fujii, et al. Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy J. Am. Coll. Cardiol., June 15, 2001; 37(8): 2086 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J Lijnen, V. V Petrov, and R. H Fagard Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors Journal of Renin-Angiotensin-Aldosterone System, June 1, 2001; 2(2): 117 - 122. [Abstract] [PDF]
|
|
|
|
|
|
R. N. Re On the Biological Actions of Intracellular Angiotensin Hypertension, June 1, 2000; 35(6): 1189 - 1190. [Full Text] [PDF]
|
|