(Hypertension. 2000;35:1183.)
© 2000 American Heart Association, Inc.
Review Articles |
Angiotensin II and the Heart
On the Intracrine Renin-Angiotensin System
From the Department of Pharmacology (W.C.D.M.), Medical Sciences Campus, University of Puerto Rico, San Juan, and the Department of Pharmacology (A.H.J.D.), Erasmus University Rotterdam, Rotterdam, the Netherlands.
Correspondence to Dr Walmor C. De Mello, Department of Pharmacology, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-5067.
Abstract—The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca2+ current.
Key Words: angiotensin • heart • hypertrophy • receptors, angiotensin • renin • signal transduction
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