(Hypertension. 2000;36:14.)
© 2000 American Heart Association, Inc.
Scientific Contributions |
Role of Tumor Necrosis Factor-
Gene Locus in Obesity and Obesity-Associated Hypertension in French Canadians
From the Centre de Recherche, Centre Hospitalier de l’Université de Montreal (CHUM) (Z.P., B.D., J.T., P.L., P.H.), Montreal, Canada; Hospital Complex of Sagamie (D.G.), Chicoutimi, Canada; and Medical College of Wisconsin (T.A.K., A.W.C.), Milwaukee, Wis.
Correspondence to Dr Pavel Hamet, Centre de Recherche, CHUM-Hôtel-Dieu, Laboratory of Molecular Medicine, 3850 St Urbain St, Montréal, Québec H2W 1T8, Canada. E-mail hamet{at}ere.umontreal.ca
Abstract—Obesity
represents a serious risk factor for the development of
cardiovascular diseases, including hypertension.
Segregation studies suggest that obesity and obesity-associated
hypertension may share some genetic determinants. The results of the
present candidate gene investigation suggest that in hypertensive
pedigrees of French-Canadian origin, one such determinant is the tumor
necrosis factor (TNF)-
gene locus. Gender-pooled quantitative
sib-pair analysis demonstrated a significant effect of the gene
locus on 3 global and 7 regional measures of obesity
(P=0.05 to 0.0004). Gender-separate quantitative
sib-pair analyses showed that the impact of the locus on
obesity is most significant in the abdominal region in men and in the
thigh region in women. Furthermore, the haplotype relative-risk test
demonstrated a significant association between the TNF- gene locus
and both obesity (P=0.006) and obesity-associated
hypertension (P=0.02). These effects were most
significant in individuals with nonmorbid obesity. In conclusion, the
results of linkage and association analyses suggest that in
hypertensive pedigrees of French-Canadian origin, the TNF- gene
locus contributes to the determination of obesity and
obesity-associated hypertension. In addition, the data indicate that
gender modifies the effect of the locus on the regional distribution of
body fat.
Key Words: tumor necrosis factor • hypertension, obesity • obesity • genes
This article has been cited by other articles:
 |
|
 |
|
  C. Bourdon, S. Hojna, M. Jordan, J. Berube, V. Kren, M. Pravenec, P. Liu, S. Arab, and Z. Pausova Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study Physiol Genomics, June 1, 2009; 38(1): 63 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I C van Eijk, M J L Peters, E H Serne, I E van der Horst-Bruinsma, B A C Dijkmans, Y M Smulders, and M T Nurmohamed Microvascular function is impaired in ankylosing spondylitis and improves after tumour necrosis factor {alpha} blockade Ann Rheum Dis, March 1, 2009; 68(3): 362 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Seda, J. Tremblay, D. Gaudet, P.-L. Brunelle, A. Gurau, E. Merlo, L. Pilote, S. N. Orlov, F. Boulva, M. Petrovich, et al. Systematic, Genome-Wide, Sex-Specific Linkage of Cardiovascular Traits in French Canadians Hypertension, April 1, 2008; 51(4): 1156 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sookoian and C. J. Pirola Review: Genetics of the cardiometabolic syndrome: new insights and therapeutic implications Therapeutic Advances in Cardiovascular Disease, October 1, 2007; 1(1): 37 - 47. [Abstract] [PDF]
|
|
|
|
 |
|
 A. M. Jonk, A. J. H. M. Houben, R. T. de Jongh, E. H. Serne, N. C. Schaper, and C. D. A. Stehouwer Microvascular Dysfunction in Obesity: A Potential Mechanism in the Pathogenesis of Obesity-Associated Insulin Resistance and Hypertension Physiology, August 1, 2007; 22(4): 252 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-H. Tang, P. Xiao, S.-F. Lei, F.-Y. Deng, L.-J. Zhao, H.-Y. Deng, L.-J. Tan, H. Shen, D.-H. Xiong, R. R. Recker, et al. A Bivariate Whole-Genome Linkage Scan Suggests Several Shared Genomic Regions for Obesity and Osteoporosis J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2751 - 2757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Serne, R. T. de Jongh, E. C. Eringa, R. G. IJzerman, and C. D.A. Stehouwer Microvascular Dysfunction: A Potential Pathophysiological Role in the Metabolic Syndrome Hypertension, July 1, 2007; 50(1): 204 - 211. [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Eringa, C. D. A. Stehouwer, K. Walburg, A. D. Clark, G. P. van Nieuw Amerongen, N. Westerhof, and P. Sipkema Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor-{alpha} Dependence on c-Jun N-Terminal Kinase Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 274 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Fernandez-Real and W. Ricart Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome Endocr. Rev., June 1, 2003; 24(3): 278 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Izawa, Y. Yamada, T. Okada, M. Tanaka, H. Hirayama, and M. Yokota Prediction of Genetic Risk for Hypertension Hypertension, May 1, 2003; 41(5): 1035 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Pausova, L. Sedova, J. Berube, P. Hamet, J. Tremblay, M. Dumont, D. Gaudet, M. Pravenec, V. Kren, and J. Kunes Segment of Rat Chromosome 20 Regulates Diet-Induced Augmentations in Adiposity, Glucose Intolerance, and Blood Pressure Hypertension, May 1, 2003; 41(5): 1047 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Fernandez-Real, M. Broch, C. Richart, J. Vendrell, A. Lopez-Bermejo, and W. Ricart CD14 Monocyte Receptor, Involved in the Inflammatory Cascade, and Insulin Sensitivity J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1780 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Kotchen, U. Broeckel, C. E. Grim, P. Hamet, H. Jacob, M. L. Kaldunski, J. M. Kotchen, N. J. Schork, P. J. Tonellato, and A. W. Cowley Jr Identification of Hypertension-Related QTLs in African American Sib Pairs Hypertension, November 1, 2002; 40(5): 634 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Villuendas, J. L. San Millan, J. Sancho, and H. F. Escobar-Morreale The -597 G->A and -174 G->C Polymorphisms in the Promoter of the IL-6 Gene Are Associated with Hyperandrogenism J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1134 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Pausova, F. Gossard, D. Gaudet, J. Tremblay, T. A. Kotchen, A. W. Cowley, and P. Hamet Heritability Estimates of Obesity Measures in Siblings With and Without Hypertension Hypertension, July 1, 2001; 38(1): 41 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Fernandez-Real, B. Lainez, J. Vendrell, M. Rigla, A. Castro, G. Penarroja, M. Broch, A. Perez, C. Richart, P. Engel, et al. Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E952 - E959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Kiemer, N. C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze, and A. M. Vollmar Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-{alpha}-Induced Actin Polymerization and Endothelial Permeability Circ. Res., May 3, 2002; 90(8): 874 - 881. [Abstract] [Full Text] [PDF]
|
|