(Hypertension. 2000;36:14.)
© 2000 American Heart Association, Inc.
Scientific Contributions |
Role of Tumor Necrosis Factor-
Gene Locus in Obesity and Obesity-Associated Hypertension in French Canadians
From the Centre de Recherche, Centre Hospitalier de l’Université de Montreal (CHUM) (Z.P., B.D., J.T., P.L., P.H.), Montreal, Canada; Hospital Complex of Sagamie (D.G.), Chicoutimi, Canada; and Medical College of Wisconsin (T.A.K., A.W.C.), Milwaukee, Wis.
Correspondence to Dr Pavel Hamet, Centre de Recherche, CHUM-Hôtel-Dieu, Laboratory of Molecular Medicine, 3850 St Urbain St, Montréal, Québec H2W 1T8, Canada. E-mail hamet{at}ere.umontreal.ca
Abstract—Obesity
represents a serious risk factor for the development of
cardiovascular diseases, including hypertension.
Segregation studies suggest that obesity and obesity-associated
hypertension may share some genetic determinants. The results of the
present candidate gene investigation suggest that in hypertensive
pedigrees of French-Canadian origin, one such determinant is the tumor
necrosis factor (TNF)-
gene locus. Gender-pooled quantitative
sib-pair analysis demonstrated a significant effect of the gene
locus on 3 global and 7 regional measures of obesity
(P=0.05 to 0.0004). Gender-separate quantitative
sib-pair analyses showed that the impact of the locus on
obesity is most significant in the abdominal region in men and in the
thigh region in women. Furthermore, the haplotype relative-risk test
demonstrated a significant association between the TNF- gene locus
and both obesity (P=0.006) and obesity-associated
hypertension (P=0.02). These effects were most
significant in individuals with nonmorbid obesity. In conclusion, the
results of linkage and association analyses suggest that in
hypertensive pedigrees of French-Canadian origin, the TNF- gene
locus contributes to the determination of obesity and
obesity-associated hypertension. In addition, the data indicate that
gender modifies the effect of the locus on the regional distribution of
body fat.
Key Words: tumor necrosis factor • hypertension, obesity • obesity • genes
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